Cristian Badea, PhD

Associate Professor in Radiology
Department: Radiology
Division: Radiology - General
Address: Bryan Research Building
Room 161F
Durham, NC 27710
Office Phone: (919) 684-7509
Email: cristian.badea@duke.edu

Research Interests

Dr. Cristian T. Badea is an Associate Professor in the Department of Radiology and faculty in the Departments of Biomedical Engineering and Medical Physics. His research focuses on pre-clinical imaging. Dr. Badea has research interests in the physics and biomedical applications of computed tomography (CT), micro-CT, tomosynthesis, fluorecence tomography and image reconstruction algorithms.


Publications

Ashton, JR; West, JL; Badea, CT. In vivo small animal micro-CT using nanoparticle contrast agents. Frontiers in Pharmacology. 2015;6:256. Abstract

Clark, DP; Lee, C-L; Kirsch, DG; Badea, CT. Spectrotemporal CT data acquisition and reconstruction at low dose. Medical physics. 2015;42:6317-6336. Abstract

Clark, DP; Badea, CT. Micro-CT of rodents: State-of-the-art and future perspectives. Physica Medica. 2014;30:619-634.

Ashton, JR; Clark, DP; Moding, EJ; Ghaghada, K; Kirsch, DG; West, JL; Badea, CT. Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. PloS one. 2014;9:e88129. Abstract

Badea, CT; Panetta, D. High-Resolution CT for Small-Animal Imaging Research. In Comprehensive Biomedical Physics. 221-242.

Clark, DP; Badea, CT. Micro-CT of rodents: state-of-the-art and future perspectives. Physica Medica. 2014;30:619-634. Abstract

Ashton, JR; Befera, N; Clark, D; Qi, Y; Mao, L; Rockman, HA; Johnson, GA; Badea, CT. Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent. Contrast Media & Molecular Imaging. 2014;9:161-168. Abstract

Lee, C-L; Min, H; Befera, N; Clark, D; Qi, Y; Das, S; Johnson, GA; Badea, CT; Kirsch, DG. Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. International Journal of Radiation Oncology, Biology, Physics. 2014;88:686-693. Abstract

Clark, DP; Ghaghada, K; Moding, EJ; Kirsch, DG; Badea, CT. In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT. Physics in Medicine and Biology. 2013;58:1683-1704. Abstract

Bhavane, R; Badea, C; Ghaghada, KB; Clark, D; Vela, D; Moturu, A; Annapragada, A; Johnson, GA; Willerson, JT; Annapragada, A. Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent. Circulation: Cardiovascular Imaging. 2013;6:285-294. Abstract

Moding, EJ; Clark, DP; Qi, Y; Li, Y; Ma, Y; Ghaghada, K; Johnson, GA; Kirsch, DG; Badea, CT. Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas. International Journal of Radiation: Oncology - Biology - Physics. 2013;85:1353-1359. Abstract

Badea, CT; Guo, X; Clark, D; Johnston, SM; Marshall, CD; Piantadosi, CA. Dual-energy micro-CT of the rodent lung. American journal of physiology. Lung cellular and molecular physiology. 2012;302:L1088-L1097. Abstract

Clark, D; Badea, A; Liu, Y; Johnson, GA; Badea, CT. Registration-based segmentation of murine 4D cardiac micro-CT data using symmetric normalization. Physics in Medicine and Biology. 2012;57:6125-6145. Abstract

Badea, CT; Stanton, IN; Johnston, SM; Johnson, GA; Therien, MJ. Investigations on X-ray luminescence CT for small animal imaging.. Proceedings of SPIE - The International Society for Optical Engineering. 83130T. Abstract

Clark, D; Johnson, GA; Badea, CT. Denoising of 4D cardiac micro-CT data using median-centric bilateral filtration. Proceedings of SPIE. Abstract

Johnston, SM; Johnson, GA; Badea, CT. Temporal and spectral imaging with micro-CT. Medical physics. 2012;39:4943-4958. Abstract

Badea, CT; Athreya, KK; Espinosa, G; Clark, D; Ghafoori, AP; Li, Y; Kirsch, DG; Johnson, GA; Annapragada, A; Ghaghada, KB. Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent. PloS one. 2012;7:e34496. Abstract

Guo, X; Johnston, SM; Qi, Y; Johnson, GA; Badea, CT. 4D micro-CT using fast prospective gating. Physics in Medicine and Biology. 2012;57:257-271. Abstract

Ghaghada, KB; Badea, CT; Karumbaiah, L; Fettig, N; Bellamkonda, RV; Johnson, GA; Annapragada, A. Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging. Academic Radiology. 2011;18:20-30. Abstract

Zhang, X; Badea, C; Hood, G; Wetzel, A; Qi, Y; Stiles, J; Johnson, GA. High-resolution reconstruction of fluorescent inclusions in mouse thorax using anatomically guided sampling and parallel Monte Carlo computing. Biomedical Optics Express. 2011;2:2449-2460. Abstract

Badea, CT; Hedlund, LW; Qi, Y; Berridge, B; Johnson, GA. In vivo imaging of rat coronary arteries using bi-plane digital subtraction angiography. Journal of Pharmacological and Toxicological Methods. 2011;64:151-157. Abstract

Badea, CT; Hedlund, LW; Cook, J; Berridge, BR; Johnson, GA. Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats. Journal of Pharmacological and Toxicological Methods. 2011;63:24-29. Abstract

Badea, CT; Johnston, SM; Qi, Y; Johnson, GA. 4D micro-CT for cardiac and perfusion applications with view under sampling. Physics in Medicine and Biology. 2011;56:3351-3369. Abstract

Lin, M; Qi, Y; Chen, AF; Badea, CT; Johnson, GA. Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography. Journal of Pharmacological and Toxicological Methods. 2011;64:180-186. Abstract

Zhang, X; Badea, CT; Hood, G; Wetzel, AW; Stiles, JR; Johnson, GA. Free-space fluorescence tomography with adaptive sampling based on anatomical information from microCT.. Proceedings of SPIE - The International Society for Optical Engineering. Abstract

Badea, CT; Johnston, SM; Subashi, E; Qi, Y; Hedlund, LW; Johnson, GA. Lung perfusion imaging in small animals using 4D micro-CT at heartbeat temporal resolution. Medical physics. 2010;37:54-62. Abstract

Johnston, SM; Perez, BA; Kirsch, DG; Badea, CT. Phase-selective image reconstruction of the lungs in small animals using Micro-CT. Proceedings of SPIE - The International Society for Optical Engineering. 2010;7622:76223G.1-76223G.9. Abstract

Zhang, X; Badea, C; Jacob, M; Johnson, GA. Development of a noncontact 3-D fluorescence tomography system for small animal in vivo imaging.. Proceedings of SPIE - The International Society for Optical Engineering. nihpa106691. Abstract

Samei, E; Saunders, RS; Badea, CT; Ghaghada, KB; Hedlund, LW; Qi, Y; Yuan, H; Bentley, RC; Mukundan, S. Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent. International journal of nanomedicine. 2009;4:277-282. Abstract

Lin, M; Marshall, CT; Qi, Y; Johnston, SM; Badea, CT; Piantadosi, CA; Johnson, GA. Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography. Medical physics. 2009;36:5347-5358. Abstract

Zhang, X; Badea, C. Effects of sampling strategy on image quality in noncontact panoramic fluorescence diffuse optical tomography for small animal imaging. Optics express. 2009;17:5125-5138. Abstract

Badea, CT; Johnston, S; Johnson, B; Lin, M; Hedlund, LW; Johnson, GA. A dual micro-CT system for small animal imaging.. Proceedings of SPIE - The International Society for Optical Engineering. 691342. Abstract

de Lin, M; Ning, L; Badea, CT; Mistry, NN; Qi, Y; Johnson, GA. A high-precision contrast injector for small animal x-ray digital subtraction angiography. IEEE Transactions on Biomedical Engineering. 2008;55:1082-1091. Abstract

Badea, CT; Hedlund, LW; De Lin, M; Mackel, JSB; Samei, E; Johnson, GA. Tomographic digital subtraction angiography for lung perfusion estimation in rodents. Medical physics. 2007;34:1546-1555. Abstract

Nahrendorf, M; Badea, C; Hedlund, LW; Figueiredo, J-L; Sosnovik, DE; Johnson, GA; Weissleder, R. High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT. American journal of physiology. Heart and circulatory physiology. 2007;292:H3172-H3178. Abstract

Song, J; Liu, QH; Johnson, GA; Badea, CT. Sparseness prior based iterative image reconstruction for retrospectively gated cardiac micro-CT. Medical physics. 2007;34:4476-4483. Abstract

Mukundan, S; Ghaghada, KB; Badea, CT; Kao, C-Y; Hedlund, LW; Provenzale, JM; Johnson, GA; Chen, E; Bellamkonda, RV; Annapragada, A. A liposomal nanoscale contrast agent for preclinical CT in mice. AJR. American journal of roentgenology. 2006;186:300-307. Abstract

Lin, MD; Samei, E; Badea, CT; Yoshizumi, TT; Johnson, GA. Optimized radiographic spectra for small animal digital subtraction angiography. Medical physics. 2006;33:4249-4257. Abstract

Badea, CT; Bucholz, E; Hedlund, LW; Rockman, HA; Johnson, GA. Imaging methods for morphological and functional phenotyping of the rodent heart. Toxicologic Pathology (Sage). 2006;34:111-117. Abstract

Badea, CT; Hedlund, LW; De Lin, M; Boslego Mackel, JF; Johnson, GA. Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents. Contrast Media & Molecular Imaging. 2006;1:153-164. Abstract

Oldham, M; Sakhalkar, H; Oliver, T; Wang, YM; Kirpatrick, J; Cao, Y; Badea, C; Johnson, GA; Dewhirst, M. Three-dimensional imaging of xenograft tumors using optical computed and emission tomography. Medical physics. 2006;33:3193-3202. Abstract

Badea, CT; Fubara, B; Hedlund, LW; Johnson, GA. 4-D micro-CT of the mouse heart. Molecular imaging : official journal of the Society for Molecular Imaging. 2005;4:110-116. Abstract

Maï, W; Badea, CT; Wheeler, CT; Hedlund, LW; Johnson, GA. Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents. Magnetic Resonance in Medicine. 2005;53:858-865. Abstract

Badea, C; Gordon, R. Experiments with the nonlinear and chaotic behaviour of the multiplicative algebraic reconstruction technique (MART) algorithm for computed tomography. Physics in Medicine and Biology. 2004;49:1455-1474. Abstract

Badea, C; Hedlund, LW; Johnson, GA. Micro-CT with respiratory and cardiac gating. Medical physics. 2004;31:3324-3329. Abstract

Soimu, D; Badea, C; Pallikarakis, N. A novel approach for distortion correction for X-ray image intensifiers. Computerized Medical Imaging and Graphics. 2003;27:79-85. Abstract

Buliev, IG; Badea, CT; Kolitsi, Z; Pallikarakis, N. Estimation of the heart respiratory motion with applications for cone beam computed tomography imaging: a simulation study. IEEE Transactions on Information Technology in Biomedicine. 2003;7:404-411. Abstract

Buliev, I; Badea, C; Pallikarakis, N. Logarithmic amplifier for computed tomography tasks using fluoroscopic projections. Journal of Medical Engineering & Technology. 2002;26:247-252. Abstract

Badea, C; Kolitsi, Z; Pallikarakis, N. Image quality in extended arc filtered digital tomosynthesis. Acta Radiologica (Informa). 2001;42:244-248. Abstract

Messaris, G; Kolitsi, Z; Badea, C; Pallikarakis, N. Three-dimensional localisation based on projectional and tomographic image correlation: an application for digital tomosynthesis. Medical Engineering & Physics. 1999;21:101-109. Abstract

Badea, C; Kolitsi, Z; Pallikarakis, N. A wavelet-based method for removal of out-of-plane structures in digital tomosynthesis. Computerized Medical Imaging and Graphics. 1998;22:309-315. Abstract

Badea, C; Kolitsi, Z; Pallikarakis, N; Papapanagiotou, A. Medical device surveillance world-wide. Studies in health technology and informatics. 1996;28:157-174. Abstract