Bastiaan Driehuys, PhD

Associate Professor in the Department of Radiology
Department: Radiology
Division: Radiology - General
Address: 161-B Bryan Research
311 Research Drive
Durham, NC 27710
Office Phone: (919) 684-7786
Email: bastiaan.driehuys@duke.edu
Web: http://www.civm.duhs.duke.edu/staffdetails.htm#Anchor-Bastiaan-35326

Research Interests

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently our focus is on using this technology to image pulmonary function regionally and non-invasively. The technology of hyperpolarization involves aligning nuclei to a high degree to enhances their MRI signal by 5-6 orders of magnitude. This  enables high-resolution imaging despite the low density of gases compared to water—the ordinary signal source in MRI. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Publications

Kaushik, SS; Freeman, MS; Cleveland, ZI; Davies, J; Stiles, J; Virgincar, RS; Robertson, SH; He, M; Kelly, KT; Foster, WM; McAdams, HP; Driehuys, B. Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging. Journal of Applied Physiology. 2013;115:850-860. Abstract

Thomas, AC; Kaushik, SS; Nouls, J; Potts, EN; Slipetz, DM; Foster, WM; Driehuys, B. Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized ³He magnetic resonance imaging in an allergic mouse model. Journal of Applied Physiology. 2012;112:1437-1444. Abstract

Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW. Small animal imaging with magnetic resonance microscopy. Institute for Laboratory Animal Research (ILAR) Journal. 2012;53:35-53.

Cleveland, ZI; Möller, HE; Hedlund, LW; Nouls, JC; Freeman, MS; Qi, Y; Driehuys, B. In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe. PLoS One. 2012;7:e31306. Abstract

Driehuys, B; Martinez-Jimenez, S; Cleveland, ZI; Metz, GM; Beaver, DM; Nouls, JC; Kaushik, SS; Firszt, R; Willis, C; Kelly, KT; Wolber, J; Kraft, M; McAdams, HP. Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology. 2012;262:279-289. Abstract

Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magnetic Resonance in Medicine. 2011;65:1154-1165. Abstract

Thomas, AC; Nouls, JC; Driehuys, B; Voltz, JW; Fubara, B; Foley, J; Bradbury, JA; Zeldin, DC. Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury. American Journal of Respiratory Cell and Molecular Biology. 2011;44:648-654. Abstract

Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kaushik, SS; Kraft, M; Wolber, J; Kelly, KT; McAdams, HP; Driehuys, B. Hyperpolarized Xe MR imaging of alveolar gas uptake in humans. PLoS One. 2010;5:e12192. Abstract

Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B. Diffusion-weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magnetic Resonance in Medicine. 2010; Abstract

Branca, RT; Cleveland, ZI; Fubara, B; Kumar, CS; Maronpot, RR; Leuschner, C; Warren, WS; Driehuys, B. Molecular MRI for sensitive and specific detection of lung metastases. Proceedings of the National Academy of Sciences of USA. 2010;107:3693-3697. Abstract

Driehuys, B; Möller, HE; Cleveland, ZI; Pollaro, J; Hedlund, LW. Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe. Radiology. 2009;252:386-393. Abstract

Cleveland, ZI; Möller, HE; Hedlund, LW; Driehuys, B. Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes. The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical. 2009;113:12489-12499. Abstract

Thomas, AC; Potts, EN; Chen, BT; Slipetz, DM; Foster, WM; Driehuys, B. A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI. NMR in Biomedicine. 2009;22:502-515. Abstract

Driehuys, B; Pollaro, J; Cofer, GP. In vivo MRI using real-time production of hyperpolarized 129Xe. Magnetic Resonance in Medicine. 2008;60:14-20. Abstract

Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW. Small animal imaging with magnetic resonance microscopy. Institute for Laboratory Animal Research (ILAR) Journal. 2008;49:35-53. Abstract

Driehuys, B; Walker, J; Pollaro, J; Cofer, GP; Mistry, N; Schwartz, D; Johnson, GA. 3He MRI in mouse models of asthma. Magnetic Resonance in Medicine. 2007;58:893-900. Abstract

Driehuys, B; Cofer, GP; Pollaro, J; Mackel, JB; Hedlund, LW; Johnson, GA. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proceedings of the National Academy of Sciences of USA. 2006;103:18278-18283. Abstract

DRIEHUYS, B. Imaging alveolar-capillary gas transfer using hyperpolarized ^<129>Xe MRI. 2006;103:18278-18283.

Driehuys, B. Chemistry. Toward molecular imaging with xenon MRI. Science. 2006;314:432-433. Abstract

Månsson, S; Wolber, J; Driehuys, B; Wollmer, P; Golman, K. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magnetic Resonance in Medicine. 2003;50:1170-1179. Abstract

Babcock, E; Nelson, I; Kadlecek, S; Driehuys, B; Anderson, LW; Hersman, FW; Walker, TG. Hybrid spin-exchange optical pumping of 3He. Physical Review Letters. 2003;91:123003. Abstract

Chann, B; Nelson, IA; Anderson, LW; Driehuys, B; Walker, TG. 129Xe-Xe molecular spin relaxation. Physical Review Letters. 2002;88:113201. Abstract

Ruppert, K; Brookeman, JR; Hagspiel, KD; Driehuys, B; Mugler, JP. NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold. NMR in Biomedicine. 2000;13:220-228. Abstract

Möller, HE; Chen, XJ; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Suddarth, SA; Johnson, GA. Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases. Magnetic Resonance in Medicine. 1999;41:800-808. Abstract

Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; MacFall, JR; Johnson, GA. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2). Magnetic Resonance in Medicine. 1999;42:729-737. Abstract

Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Johnson, GA. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient. Magnetic Resonance in Medicine. 1999;42:721-728. Abstract

Möller, HE; Chen, XJ; Chawla, MS; Driehuys, B; Hedlund, LW; Johnson, GA. Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases. Journal of Magnetic Resonance. 1998;135:133-143. Abstract

Johnson, GA; Cates, G; Chen, XJ; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Saam, B; Shattuck, MD; Swartz, J. Dynamics of magnetization in hyperpolarized gas MRI of the lung. Magnetic Resonance in Medicine. 1997;38:66-71. Abstract

Mugler, JP; Driehuys, B; Brookeman, JR; Cates, GD; Berr, SS; Bryant, RG; Daniel, TM; de Lange, EE; Downs, JH; Erickson, CJ; Happer, W; Hinton, DP; Kassel, NF; Maier, T; Phillips, CD; Saam, BT; Sauer, KL; Wagshul, ME. MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results. Magnetic Resonance in Medicine. 1997;37:809-815. Abstract

Driehuys, B; Cates, GD; Miron, E; Sauer, K; Walter, DK; Happer, W. High-volume production of laser-polarized 129Xe. 1996;69:1668-1670.

MacFall, JR; Charles, HC; Black, RD; Middleton, H; Swartz, JC; Saam, B; Driehuys, B; Erickson, C; Happer, W; Cates, GD; Johnson, GA; Ravin, CE. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology. 1996;200:553-558. Abstract

Black, RD; Middleton, HL; Cates, GD; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Johnson, GA; Shattuck, MD; Swartz, JC. In vivo He-3 MR images of guinea pig lungs. Radiology. 1996;199:867-870. Abstract

Driehuys, B; Cates, GD; Happer, W. Surface relaxation mechanisms of laser-polarized 129Xe. Physical Review Letters. 1995;74:4943-4946. Abstract

Albert, MS; Cates, GD; Driehuys, B; Happer, W; Saam, B; Springer, CS; Wishnia, A. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature. 1994;370:199-201. Abstract

Gatzke, M; Cates, GD; Driehuys, B; Fox, D; Happer, W; Saam, B. Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe. Physical Review Letters. 1993;70:690-693. Abstract