Bastiaan Driehuys, PhD

Professor of Radiology
Department: Radiology
Division: Radiology - General
Address: 161-B Bryan Research
311 Research Drive
Durham, NC 27710
Office Phone: (919) 684-7786
Email: bastiaan.driehuys@duke.edu
Web: http://www.civm.duhs.duke.edu/staffdetails.htm#Anchor-Bastiaan-35326

Research Interests

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Publications

Kaushik, SS; Freeman, MS; Cleveland, ZI; Davies, J; Stiles, J; Virgincar, RS; Robertson, SH; He, M; Kelly, KT; Foster, WM; McAdams, HP; Driehuys, B. Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging. Journal of applied physiology (Bethesda, Md. : 1985). 2013;115:850-860. Abstract

Driehuys, B; Martinez-Jimenez, S; Cleveland, ZI; Metz, GM; Beaver, DM; Nouls, JC; Kaushik, SS; Firszt, R; Willis, C; Kelly, KT; Wolber, J; Kraft, M; McAdams, HP. Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology. 2012;262:279-289. Abstract

Cleveland, ZI; Möller, HE; Hedlund, LW; Nouls, JC; Freeman, MS; Qi, Y; Driehuys, B. In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe. PloS one. 2012;7:e31306. Abstract

Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW. Small animal imaging with magnetic resonance microscopy. ILAR Journal. 2012;53:35-53.

Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magnetic Resonance in Medicine. 2011;65:1154-1165. Abstract

Thomas, AC; Nouls, JC; Driehuys, B; Voltz, JW; Fubara, B; Foley, J; Bradbury, JA; Zeldin, DC. Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury. American journal of respiratory cell and molecular biology. 2011;44:648-654. Abstract

Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B. Diffusion-weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magnetic Resonance in Medicine. 2010; Abstract

Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kaushik, SS; Kraft, M; Wolber, J; Kelly, KT; McAdams, HP; Driehuys, B. Hyperpolarized Xe MR imaging of alveolar gas uptake in humans. PloS one. 2010;5:e12192. Abstract

Branca, RT; Cleveland, ZI; Fubara, B; Kumar, CS; Maronpot, RR; Leuschner, C; Warren, WS; Driehuys, B. Molecular MRI for sensitive and specific detection of lung metastases. Proceedings of the National Academy of Sciences of USA. 2010;107:3693-3697. Abstract

Driehuys, B; Möller, HE; Cleveland, ZI; Pollaro, J; Hedlund, LW. Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe. Radiology. 2009;252:386-393. Abstract

Cleveland, ZI; Möller, HE; Hedlund, LW; Driehuys, B. Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes. The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical. 2009;113:12489-12499. Abstract

Thomas, AC; Potts, EN; Chen, BT; Slipetz, DM; Foster, WM; Driehuys, B. A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI. Nmr in Biomedicine. 2009;22:502-515. Abstract

Driehuys, B; Pollaro, J; Cofer, GP. In vivo MRI using real-time production of hyperpolarized 129Xe. Magnetic Resonance in Medicine. 2008;60:14-20. Abstract

Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW. Small animal imaging with magnetic resonance microscopy. ILAR Journal. 2008;49:35-53. Abstract

Driehuys, B; Walker, J; Pollaro, J; Cofer, GP; Mistry, N; Schwartz, D; Johnson, GA. 3He MRI in mouse models of asthma. Magnetic Resonance in Medicine. 2007;58:893-900. Abstract

DRIEHUYS, B. Imaging alveolar-capillary gas transfer using hyperpolarized ^<129>Xe MRI. 2006;103:18278-18283.

Driehuys, B. Chemistry. Toward molecular imaging with xenon MRI. Science. 2006;314:432-433. Abstract

Driehuys, B; Cofer, GP; Pollaro, J; Mackel, JB; Hedlund, LW; Johnson, GA. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proceedings of the National Academy of Sciences of USA. 2006;103:18278-18283. Abstract

Månsson, S; Wolber, J; Driehuys, B; Wollmer, P; Golman, K. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magnetic Resonance in Medicine. 2003;50:1170-1179. Abstract

Babcock, E; Nelson, I; Kadlecek, S; Driehuys, B; Anderson, LW; Hersman, FW; Walker, TG. Hybrid spin-exchange optical pumping of 3He. Physical Review Letters. 2003;91:123003. Abstract

Chann, B; Nelson, IA; Anderson, LW; Driehuys, B; Walker, TG. 129Xe-Xe molecular spin relaxation. Physical Review Letters. 2002;88:113201. Abstract

Ruppert, K; Brookeman, JR; Hagspiel, KD; Driehuys, B; Mugler, JP. NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold. Nmr in Biomedicine. 2000;13:220-228. Abstract

Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Johnson, GA. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient. Magnetic Resonance in Medicine. 1999;42:721-728. Abstract

Möller, HE; Chen, XJ; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Suddarth, SA; Johnson, GA. Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases. Magnetic Resonance in Medicine. 1999;41:800-808. Abstract

Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; MacFall, JR; Johnson, GA. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2). Magnetic Resonance in Medicine. 1999;42:729-737. Abstract

Möller, HE; Chen, XJ; Chawla, MS; Driehuys, B; Hedlund, LW; Johnson, GA. Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases. Journal of Magnetic Resonance. 1998;135:133-143. Abstract

Johnson, GA; Cates, G; Chen, XJ; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Saam, B; Shattuck, MD; Swartz, J. Dynamics of magnetization in hyperpolarized gas MRI of the lung. Magnetic Resonance in Medicine. 1997;38:66-71. Abstract

Mugler, JP; Driehuys, B; Brookeman, JR; Cates, GD; Berr, SS; Bryant, RG; Daniel, TM; de Lange, EE; Downs, JH; Erickson, CJ; Happer, W; Hinton, DP; Kassel, NF; Maier, T; Phillips, CD; Saam, BT; Sauer, KL; Wagshul, ME. MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results. Magnetic Resonance in Medicine. 1997;37:809-815. Abstract

Driehuys, B; Cates, GD; Miron, E; Sauer, K; Walter, DK; Happer, W. High-volume production of laser-polarized 129Xe. 1996;69:1668-1670.

Black, RD; Middleton, HL; Cates, GD; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Johnson, GA; Shattuck, MD; Swartz, JC. In vivo He-3 MR images of guinea pig lungs. Radiology. 1996;199:867-870. Abstract

MacFall, JR; Charles, HC; Black, RD; Middleton, H; Swartz, JC; Saam, B; Driehuys, B; Erickson, C; Happer, W; Cates, GD; Johnson, GA; Ravin, CE. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology. 1996;200:553-558. Abstract

Driehuys, B; Cates, GD; Happer, W. Surface relaxation mechanisms of laser-polarized 129Xe. Physical Review Letters. 1995;74:4943-4946. Abstract

Albert, MS; Cates, GD; Driehuys, B; Happer, W; Saam, B; Springer, CS; Wishnia, A. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature. 1994;370:199-201. Abstract

Gatzke, M; Cates, GD; Driehuys, B; Fox, D; Happer, W; Saam, B. Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe. Physical Review Letters. 1993;70:690-693. Abstract