G Allan Johnson, PhD

Professor of Radiology
Department: Radiology
Division: Radiology - General
Address: 141D Bryan Neuroscience Bldg
Research Drive
Durham, NC 27710
Office Phone: (919) 684-7754
Email: gjohnson@duke.edu
Web: http://www.civm.duhs.duke.edu

Research Interests

Dr. Johnson is the Charles E. Putman University Professor of Radiology, Professor of Physics, and Biomedical Engineering, and Director of the Duke Center for In Vivo Microscopy (CIVM). The CIVM is an NIH/NIBIB national Biomedical Technology Resource Center with a mission to develop novel technologies for preclinical imaging (basic sciences) and apply the technologies to critical biomedical questions. Dr. Johnson was one of the first researchers to bring Paul Lauterbur's vision of magnetic resonance (MR) microscopy to practice as described in his paper, "Nuclear magnetic resonance imaging at microscopic resolution" (J Magn Reson 68:129-137, 1986). Dr. Johnson is involved in both the engineering physics required to extend the resolution of MR imaging and in a broad range of applications in the basic sciences.


Calabrese, E; Badea, A; Cofer, G; Qi, Y; Johnson, GA. A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data. Cerebral Cortex. 2015;25:4628-4637. Abstract

Johnson, GA. Magnetic resonance histology. Journal of Magnetic Resonance Imaging. 2015;42:1-2. Abstract

Borg, JS; Vu, M-A; Badea, C; Badea, A; Johnson, GA; Dzirasa, K. Localization of Metal Electrodes in the Intact Rat Brain Using Registration of 3D Microcomputed Tomography Images to a Magnetic Resonance Histology Atlas. eNeuro. 2015;2. Abstract

Papp, EA; Leergaard, TB; Calabrese, E; Johnson, GA; Bjaalie, JG. Addendum to ¿Waxholm Space atlas of the Sprague Dawley rat brain¿ [NeuroImage 97 (2014) 374-386]. NeuroImage. 2015;105:561-562. Abstract

Xie, L; Dibb, R; Cofer, GP; Li, W; Nicholls, PJ; Johnson, GA; Liu, C. Susceptibility tensor imaging of the kidney and its microstructural underpinnings. Magnetic Resonance in Medicine. 2015;73:1270-1281.

Subashi, E; Qi, Y; Johnson, GA. Dynamic contrast-enhanced MR microscopy identifies regions of therapeutic response in a preclinical model of colorectal adenocarcinoma. Medical physics. 2015;42:2482-2488. Abstract

Xie, L; Qi, Y; Subashi, E; Liao, G; Miller-DeGraff, L; Jetten, AM; Johnson, GA. 4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice. Nmr in Biomedicine. 2015;28:546-554. Abstract

Paxinos, G; Watson, C; Calabrese, E; Badea, A; Johnson, G. Elsevier Academic Press.

Calabrese, E; Hickey, P; Hulette, C; Zhang, J; Parente, B; Lad, SP; Johnson, GA. Postmortem diffusion MRI of the human brainstem and thalamus for deep brain stimulator electrode localization. Human Brain Mapping. 2015;36:3167-3178. Abstract

Calabrese, E; Badea, A; Coe, CL; Lubach, GR; Shi, Y; Styner, MA; Johnson, GA. A diffusion tensor MRI atlas of the postmortem rhesus macaque brain. NeuroImage. 2015;117:408-416. Abstract

Calabrese, E; Du, F; Garman, RH; Johnson, GA; Riccio, C; Tong, LC; Long, JB. Diffusion tensor imaging reveals white matter injury in a rat model of repetitive blast-induced traumatic brain injury. Journal of Neurotrauma. 2014;31:938-950. Abstract

Calabrese, E; Badea, A; Coe, CL; Lubach, GR; Styner, MA; Johnson, GA. Investigating the tradeoffs between spatial resolution and diffusion sampling for brain mapping with diffusion tractography: time well spent?. Human Brain Mapping. 2014;35:5667-5685. Abstract

Papp, EA; Leergaard, TB; Calabrese, E; Johnson, GA; Bjaalie, JG. Waxholm Space atlas of the Sprague Dawley rat brain. NeuroImage. 2014;97:374-386. Abstract

Johnson, GA; Calabrese, E; Little, PB; Hedlund, L; Qi, Y; Badea, A. Quantitative mapping of trimethyltin injury in the rat brain using magnetic resonance histology. NeuroToxicology. 2014;42:12-23. Abstract

Johnson, GA; Badea, A; Calabrese, E; Liu, C; Xie, L. Magnetic resonance histology¿Applications in toxicology. Toxicology Letters. S31-S32.

Xie, L; Subashi, E; Qi, Y; Knepper, MA; Johnson, GA. Four-dimensional MRI of renal function in the developing mouse. Nmr in Biomedicine. 2014;27:1094-1102. Abstract

Subashi, E; Moding, EJ; Cofer, GP; MacFall, JR; Kirsch, DG; Qi, Y; Johnson, GA. A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models. 2013;40:022304. Abstract

Johnson, GA; Badea, A; Calabrese, E; Liu, C; Xie, L. Magnetic resonance histology: cool images- but who cares?. Toxicology Letters. 2013;221:S50-S50.

Badea, A; Johnson, GA. Magnetic resonance microscopy. Studies in health technology and informatics. 2013;185:153-184. Abstract

Gyengesi, E; Calabrese, E; Sherrier, MC; Johnson, GA; Paxinos, G; Watson, C. Semi-automated 3D segmentation of major tracts in the rat brain: comparing DTI with standard histological methods. Brain Structure and Function. 2013;1-12. Abstract

Pandit, P; Johnston, SM; Qi, Y; Story, J; Nelson, R; Johnson, GA. The utility of micro-CT and MRI in the assessment of longitudinal growth of liver metastases in a preclinical model of colon carcinoma. Academic Radiology. 2013;20:430-439. Abstract

Calabrese, E; Johnson, GA. Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain. NeuroImage. 2013;79:329-339. Abstract

Calabrese, E; Johnson, GA; Watson, C. An ontology-based segmentation scheme for tracking postnatal changes in the developing rodent brain with MRI. NeuroImage. 2013;67:375-384. Abstract

Liu, C; Li, W; Wu, B; Jiang, Y; Johnson, GA. 3D fiber tractography with susceptibility tensor imaging. NeuroImage. 2012;59:1290-1298. Abstract

Johnson, GA; Calabrese, E; Badea, A; Paxinos, G; Watson, C. A multidimensional magnetic resonance histology atlas of the Wistar rat brain. NeuroImage. 2012;62:1848-1856. Abstract

Lipinski, RJ; Hammond, P; O'Leary-Moore, SK; Ament, JJ; Pecevich, SJ; Jiang, Y; Budin, F; Parnell, SE; Suttie, M; Godin, EA; Everson, JL; Dehart, DB; Oguz, I; Holloway, HT; Styner, MA; Johnson, GA; Sulik, KK. Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent. PloS one. 2012;7. Abstract

Badea, A; Gewalt, S; Avants, BB; Cook, JJ; Johnson, GA. Quantitative mouse brain phenotyping based on single and multispectral MR protocols. NeuroImage. 2012;63:1633-1645. Abstract

Guo, X; Johnston, SM; Qi, Y; Johnson, GA; Badea, CT. 4D micro-CT using fast prospective gating. Physics in Medicine and Biology. 2012;57:257-271. Abstract

Badea, A; Johnson, GA. Magnetic resonance microscopy. Analytical Cellular Pathology. 2012;35:205-227. Abstract

Veraart, J; Leergaard, TB; Antonsen, BT; Van Hecke, W; Blockx, I; Jeurissen, B; Jiang, Y; Van der Linden, A; Johnson, GA; Verhoye, M; Sijbers, J. Population-averaged diffusion tensor imaging atlas of the Sprague Dawley rat brain. NeuroImage. 2011;58:975-983. Abstract

Johnson, GA; Badea, A; Jiang, Y. Quantitative neuromorphometry using magnetic resonance histology. Toxicologic Pathology (Sage). 2011;39:85-91. Abstract

Liu, C; Li, W; Johnson, GA; Wu, B. High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. NeuroImage. 2011;56:930-938. Abstract

Hawrylycz, M; Baldock, RA; Burger, A; Hashikawa, T; Johnson, GA; Martone, M; Ng, L; Lau, C; Larson, SD; Nissanov, J; Puelles, L; Ruffins, S; Verbeek, F; Zaslavsky, I; Boline, J. Digital atlasing and standardization in the mouse brain. PLoS computational biology. 2011;7:e1001065. Abstract

Bowden, DM; Johnson, GA; Zaborsky, L; Green, WDK; Moore, E; Badea, A; Dubach, MF; Bookstein, FL. A symmetrical Waxholm canonical mouse brain for NeuroMaps. Journal of Neuroscience Methods. 2011;195:170-175. Abstract

Jiang, Y; Johnson, GA. Microscopic diffusion tensor imaging of the mouse brain. NeuroImage. 2010;50:465-471. Abstract

Petiet, A; Johnson, GA. Active staining of mouse embryos for magnetic resonance microscopy. Methods in molecular biology (Clifton, N.J.). 2010;611:141-149. Abstract

Pandit, P; Qi, Y; Story, J; King, KF; Johnson, GA. Multishot PROPELLER for high-field preclinical MRI. Magnetic Resonance in Medicine. 2010;64:47-53. Abstract

Mistry, NN; Qi, Y; Hedlund, LW; Johnson, GA. Ventilation/perfusion imaging in a rat model of airway obstruction. Magnetic Resonance in Medicine. 2010;63:728-735. Abstract

Johnson, GA; Badea, A; Brandenburg, J; Cofer, G; Fubara, B; Liu, S; Nissanov, J. Waxholm space: an image-based reference for coordinating mouse brain research. NeuroImage. 2010;53:365-372. Abstract

Badea, A; Johnson, GA; Jankowsky, JL. Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease. NeuroImage. 2010;50:416-427. Abstract

Badea, A; Johnson, GA; Williams, RW. Genetic dissection of the mouse CNS using magnetic resonance microscopy. Current Opinion in Neurology. 2009;22:379-386. Abstract

Sharief, AA; Badea, A; Dale, AM; Johnson, GA. Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy. NeuroImage. 2008;39:136-145. Abstract

Johnson, GA; Ali-Sharief, A; Badea, A; Brandenburg, J; Cofer, G; Fubara, B; Gewalt, S; Hedlund, LW; Upchurch, L. High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology. NeuroImage. 2007;37:82-89. Abstract

Ali, AA; Dale, AM; Badea, A; Johnson, GA. Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain. NeuroImage. 2005;27:425-435. Abstract

Johnson, GA; Hedlund, LW. Image based phenotyping: The visible mouse. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002;16:A1091-A1091.

Johnson, GA; Cofer, GP; Gewalt, SL; Hedlund, LW. Morphologic phenotyping with MR microscopy: the visible mouse. Radiology. 2002;222:789-793. Abstract

Johnson, GA; Cofer, GP; Gewalt, SL; Hedlund, LW; IEEE, ; IEEE, . An engineering approach to image-based phenotyping. 381-383.

Johnson, GA; Benveniste, H; Engelhardt, RT; Qiu, H; Hedlund, LW. Magnetic resonance microscopy in basic studies of brain structure and function. Annals of the New York Academy of Sciences. 1997;820:139-147. Abstract

Johnson, GA; Benveniste, H; Black, RD; Hedlund, LW; Maronpot, RR; Smith, BR. Histology by magnetic resonance microscopy. Magnetic resonance quarterly. 1993;9:1-30. Abstract

Johnson, GA; Thompson, MB; Gewalt, SL; Hayes, CE. Nuclear magnetic resonance imaging at microscopic resolution. Journal of Magnetic Resonance (1969). 1986;68:129-137.