James MacFall, PhD

Adjunct Professor in the Department of Radiology
Department: Radiology
Division: Radiology - General
Address: 1812C Hosp North
Durham, NC 27710
Office Phone: (919) 684-7808
Email: james.macfall@duke.edu
Web: http://camrd4.mc.duke.edu/camrdwebpages/jrmhome.html

Research Interests

My research centers on application and/or development of image processing and magnetic resonance imaging (MRI) techniques for a variety of biomedical focus areas in Psychiatry, Oncology, Lung Disorders and Pediatric Neurological Disorders:
Psychiatry: Research is focused on improving automated methods of brain tissue identification and volume measurement using magnetic resonance images in the context of a study of depression in aging. Similar work is ongoing in bipolar disorder. We are also developing ways to use diffusion tensor imaging to assess the damage caused by vascular lesions to white matter tracts.
Oncology: Research efforts center on how to best quantitate MRI-based diffusion and perfusion parameters and apply them to predicting the course and outcome of cancer therapy. Current efforts involve developing robust algorithms for removing distortion from echo-planar MR diffusion images and producing high resolution MR diffusion images on our research 3 Tesla MR imaging system (Center for Advanced MR Development, CAMRD). I am also collaborating with Radiologists and Oncologists to develop rapid quantitation of tumor vascular permeability and relate changes in the permeability to a variety of vascular targeted therapies in clinical trials. A second effort centers on using MRI to monitor temperature and other tissue parameters during hyperthermia therapy.
Pediatric Neurology/Psychiatry: I am collaborating with researchers at Duke to use MRI methods to evaluate childhood epilepsy, addictions, trauma and abuse. Some of these involve multi-site studies. We are developing ways to use new technology available for advanced analysis and data mining  for such multi-site research.
All of this work is very collaborative between technology oriented and disease oriented researchers. There are continuing opportunities in my group for student research with subsets of data currently under analysis.
Lung Disorders: The lung is particularly challenging to image with MRI. I am collaborating with colleagues to develop MRI methods to image the lungs to provide non-invasive biomarkers for Chronic Obstructive Lung Disease (COPD).


Taylor, WD; Zhao, Z; Ashley-Koch, A; Payne, ME; Steffens, DC; Krishnan, RR; Hauser, E; MacFall, JR. Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype. Human Brain Mapping. 2013;34:295-303. Abstract

Craciunescu, OI; Yoo, DS; Cleland, E; Muradyan, N; Carroll, MD; MacFall, JR; Barboriak, DP; Brizel, DM. Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters. International Journal of Radiation: Oncology - Biology - Physics. 2012;82:e345-e350. Abstract

Chi, J-T; Thrall, DE; Jiang, C; Snyder, S; Fels, D; Landon, C; McCall, L; Lan, L; Hauck, M; MacFall, JR; Viglianti, BL; Dewhirst, MW. Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011;17:2549-2560. Abstract

Taylor, WD; Macfall, JR; Boyd, B; Payne, ME; Sheline, YI; Krishnan, RR; Murali Doraiswamy, P. One-year change in anterior cingulate cortex white matter microstructure: relationship with late-life depression outcomes. American Journal of Geriatric Psychiatry. 2011;19:43-52. Abstract

Benjamin, S; McQuoid, DR; Potter, GG; Payne, ME; MacFall, JR; Steffens, DC; Taylor, WD. The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. American Journal of Geriatric Psychiatry. 2010;18:323-331. Abstract

Soher, BJ; Wyatt, C; Reeder, SB; MacFall, JR. Noninvasive temperature mapping with MRI using chemical shift water-fat separation. Magnetic Resonance in Medicine. 2010;63:1238-1246. Abstract

Wyatt, CR; Soher, BJ; MacFall, JR. Correction of breathing-induced errors in magnetic resonance thermometry of hyperthermia using multiecho field fitting techniques. Medical physics. 2010;37:6300-6309. Abstract

Sheline, YI; Pieper, CF; Barch, DM; Welsh-Bohmer, K; McKinstry, RC; MacFall, JR; D'Angelo, G; Garcia, KS; Gersing, K; Wilkins, C; Taylor, W; Steffens, DC; Krishnan, RR; Doraiswamy, PM. Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial. Archives of General Psychiatry. 2010;67:277-285. Abstract

Hazlett, HC; Poe, MD; Lightbody, AA; Gerig, G; Macfall, JR; Ross, AK; Provenzale, J; Martin, A; Reiss, AL; Piven, J. Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism. Journal of Neurodevelopmental Disorders. 2009;1:81-90. Abstract

Craciunescu, OI; Blackwell, KL; Jones, EL; Macfall, JR; Yu, D; Vujaskovic, Z; Wong, TZ; Liotcheva, V; Rosen, EL; Prosnitz, LR; Samulski, TV; Dewhirst, MW. DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study. International Journal of Hyperthermia (Informa). 2009;25:405-415. Abstract

Craciunescu, OI; Stauffer, PR; Soher, BJ; Wyatt, CR; Arabe, O; Maccarini, P; Das, SK; Cheng, K-S; Wong, TZ; Jones, EL; Dewhirst, MW; Vujaskovic, Z; MacFall, JR. Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. Medical physics. 2009;36:4848-4858. Abstract

Barboriak, DP; MacFall, JR; Viglianti, BL; Dewhirst Dvm, MW. Comparison of three physiologically-based pharmacokinetic models for the prediction of contrast agent distribution measured by dynamic MR imaging. Journal of Magnetic Resonance Imaging. 2008;27:1388-1398. Abstract

Kim, KW; MacFall, JR; Payne, ME. Classification of white matter lesions on magnetic resonance imaging in elderly persons. Biological Psychiatry. 2008;64:273-280. Abstract

Zhao, Z; Taylor, WD; Styner, M; Steffens, DC; Krishnan, KRR; MacFall, JR. Hippocampus shape analysis and late-life depression. PloS one. 2008;3:e1837. Abstract

Taylor, WD; MacFall, JR; Gerig, G; Krishnan, RR. Structural integrity of the uncinate fasciculus in geriatric depression: Relationship with age of onset. Neuropsychiatric disease and treatment. 2007;3:669-674. Abstract

MacFall, JR; Soher, BJ. From the RSNA refresher courses: MR imaging in hyperthermia. Radiographics : a review publication of the Radiological Society of North America, Inc. 2007;27:1809-1818. Abstract

Taylor, WD; Macfall, JR; Payne, ME; McQuoid, DR; Steffens, DC; Provenzale, JM; Krishnan, KRR. Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms. Psychological Medicine. 2007;37:1763-1773. Abstract

Michelich, CR; Song, AW; Macfall, JR. Dependence of gradient-echo and spin-echo BOLD fMRI at 4 T on diffusion weighting. Nmr in Biomedicine. 2006;19:566-572. Abstract

Viglianti, BL; Ponce, AM; Michelich, CR; Yu, D; Abraham, SA; Sanders, L; Yarmolenko, PS; Schroeder, T; MacFall, JR; Barboriak, DP; Colvin, OM; Bally, MB; Dewhirst, MW. Chemodosimetry of in vivo tumor liposomal drug concentration using MRI. Magnetic Resonance in Medicine. 2006;56:1011-1018. Abstract

Bae, JN; MacFall, JR; Krishnan, KRR; Payne, ME; Steffens, DC; Taylor, WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biological Psychiatry. 2006;60:1356-1363. Abstract

MacFall, JR; Taylor, WD; Rex, DE; Pieper, S; Payne, ME; McQuoid, DR; Steffens, DC; Kikinis, R; Toga, AW; Krishnan, KRR. Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN). Neuropsychopharmacology (Nature). 2006;31:1500-1507. Abstract

Taylor, WD; MacFall, JR; Payne, ME; McQuoid, DR; Steffens, DC; Provenzale, JM; Krishnan, RR. Greater MRI lesion volumes in elderly depressed subjects than in control subjects. Psychiatry Research. 2005;139:1-7. Abstract

Viglianti, BL; Abraham, SA; Michelich, CR; Yarmolenko, PS; MacFall, JR; Bally, MB; Dewhirst, MW. In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. Magnetic Resonance in Medicine. 2004;51:1153-1162. Abstract

Taylor, WD; MacFall, JR; Payne, ME; McQuoid, DR; Provenzale, JM; Steffens, DC; Krishnan, KRR. Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. American Journal of Psychiatry. 2004;161:1293-1296. Abstract

Taylor, WD; Hsu, E; Krishnan, KRR; MacFall, JR. Diffusion tensor imaging: background, potential, and utility in psychiatric research. Biological Psychiatry. 2004;55:201-207. Abstract

Taylor, WD; MacFall, JR; Steffens, DC; Payne, ME; Provenzale, JM; Krishnan, KRR. Localization of age-associated white matter hyperintensities in late-life depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2003;27:539-544. Abstract

Taylor, WD; MacFall, JR; Provenzale, JM; Payne, ME; McQuoid, DR; Steffens, DC; Krishnan, KRR. Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors. AJR. American journal of roentgenology. 2003;181:571-576. Abstract

Lewis, DV; Barboriak, DP; MacFall, JR; Provenzale, JM; Mitchell, TV; VanLandingham, KE. Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions. Progress in Brain Research. 2002;135:263-278. Abstract

Guo, AC; MacFall, JR; Provenzale, JM. Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter. Radiology. 2002;222:729-736. Abstract

Hsieh, M-H; McQuoid, DR; Levy, RM; Payne, ME; MacFall, JR; Steffens, DC. Hippocampal volume and antidepressant response in geriatric depression. International Journal of Geriatric Psychiatry. 2002;17:519-525. Abstract

Steffens, DC; Bosworth, HB; Provenzale, JM; MacFall, JR. Subcortical white matter lesions and functional impairment in geriatric depression. Depression and Anxiety. 2002;15:23-28. Abstract

MacFall, JR; Payne, ME; Provenzale, JE; Krishnan, KR. Medial orbital frontal lesions in late-onset depression. Biological Psychiatry. 2001;49:803-806. Abstract

Kao, YH; MacFall, JR. Correction of MR kappa-space data corrupted by spike noise. IEEE Transactions on Medical Imaging. 2000;19:671-680. Abstract

Craciunescu, OI; Samulski, TV; MacFall, JR; Clegg, ST. Perturbations in hyperthermia temperature distributions associated with counter-current flow: numerical simulations and empirical verification. IEEE Transactions on Biomedical Engineering. 2000;47:435-443. Abstract

Engelter, ST; Provenzale, JM; Petrella, JR; DeLong, DM; MacFall, JR. The effect of aging on the apparent diffusion coefficient of normal-appearing white matter. AJR. American journal of roentgenology. 2000;175:425-430. Abstract

Vujaskovic, Z; Poulson, JM; Gaskin, AA; Thrall, DE; Page, RL; Charles, HC; MacFall, JR; Brizel, DM; Meyer, RE; Prescott, DM; Samulski, TV; Dewhirst, MW. Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment. International Journal of Radiation Oncology, Biology, Physics. 2000;46:179-185. Abstract

Donnelly, LF; MacFall, JR; McAdams, HP; Majure, JM; Smith, J; Frush, DP; Bogonad, P; Charles, HC; Ravin, CE. Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations. Radiology. 1999;212:885-889. Abstract

Kao, YH; Wan, X; MacFall, JR. Simultaneous multislice acquisition with arterial-flow tagging (SMART) using echo planar imaging (EPI). Magnetic Resonance in Medicine. 1998;39:662-665. Abstract

Carter, DL; MacFall, JR; Clegg, ST; Wan, X; Prescott, DM; Charles, HC; Samulski, TV. Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma. International Journal of Radiation Oncology, Biology, Physics. 1998;40:815-822. Abstract

MacFall, JR; Charles, HC; Black, RD; Middleton, H; Swartz, JC; Saam, B; Driehuys, B; Erickson, C; Happer, W; Cates, GD; Johnson, GA; Ravin, CE. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology. 1996;200:553-558. Abstract

MacFall, JR; Prescott, DM; Charles, HC; Samulski, TV. 1H MRI phase thermometry in vivo in canine brain, muscle, and tumor tissue. Medical physics. 1996;23:1775-1782. Abstract

MacFall, JR; Byrum, CE; Parashos, I; Early, B; Charles, HC; Chittilla, V; Boyko, OB; Upchurch, L; Krishnan, KR. Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods. Psychiatry Research. 1994;55:167-177. Abstract

Foo, TK; MacFall, JR; Sostman, HD; Hayes, CE. Single-breath-hold venous or arterial flow-suppressed pulmonary vascular MR imaging with phased-array coils. Journal of Magnetic Resonance Imaging. 1993;3:611-616. Abstract

Wu, JJ; MacFall, JR; Sostman, HD; Hedlund, LW. Clot-blood contrast in fast gradient-echo magnetic resonance imaging. Investigative Radiology. 1993;28:586-593. Abstract

Foo, TK; MacFall, JR; Hayes, CE; Sostman, HD; Slayman, BE. Pulmonary vasculature: single breath-hold MR imaging with phased-array coils. Radiology. 1992;183:473-477. Abstract

MacFall, JR; Sostman, HD; Foo, TK. Thick-section, single breath-hold magnetic resonance pulmonary angiography. Investigative Radiology. 1992;27:318-322. Abstract