Ganesan Vaidyanathan, PhD

Professor in Radiology
Department: Radiology
Division: Radiology - General
Address: 161C Bryan Res Bldg
Durham, NC 27710
Office Phone: (919) 684-7811
Email: vaidy001@mc.duke.edu

Research Interests

Dr. Vaidyanathan is a professor in the Department of Radiology.  He is a member of the Nuclear Medicine track of the Medical Physics Graduate Program.  His research involves development of radiopharmaceuticals especially for oncologic applications.  Some of the projects he is involved in are given below.

I.          New methods of radiohalogenating antibodies and its variants 

a) Development of newer residualizing agents for the radiohalogenation of internalizing monoclonal antibodies.

b)  Development of fluorine-18 labeled residualizing agents for labeling nanobodies.

c) Pre-targeting approach via bioorthogonal chemistry for in vivo labeling of antibodies and nanobodies with 18F and 211At.

d)  Methods to label antibodies pre-conjugated with a prosthetic group of the tin precursor of residualizing agents.

e) Multimodal prosthetic groups for labeling antibodies and peptides with multiple radioisotopes.

II.         MIBG Analogs for PET imaging

Radioiodinated MIBG is used in the diagnosis of the pathophysiology of the heart as well as neuroendocrine tumors such as neuroblastoma (NB).  Design and development of newer fluorine-18 labeled MIBG analogues useful in the PET imaging of NB as well as that of myocardial diseases.

III. Noninvasive Imaging of Alkylguanine-DNA alkyltransferase (AGT) 

AGT is a DNA repair protein and is primarily responsible for drug resistance in alkylator chemotherapy. An inverse correlation has been established between the tumor AGT content and the therapeutic outcome. The amount of AGT varies from tumor to tumor and within a group of patients of similar cancer. Thus, it is important to quantify tumor AGT of individual patients before administering alkylator chemotherapy. Our goal is to develop radiolabeled agents with which AGT can be quantified in a noninvasive manner by PET or SPECT imaging. 

IV. PSMA targeting for prostate cancer therapy 

Development of At-211 labeled urea-based inhibitor of Prostate-specific membrane antigen.

Publications

Pruszynski, M; Koumarianou, E; Vaidyanathan, G; Revets, H; Devoogdt, N; Lahoutte, T; Zalutsky, MR. Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody. Nuclear Medicine and Biology. 2013;40:52-59.

Slastnikova, TA; Koumarianou, E; Rosenkranz, AA; Vaidyanathan, G; Lupanova, TN; Sobolev, AS; Zalutsky, MR. Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I. EJNMMI Research. 2012;2:59. Abstract

Chin, BB; Hjelemand, A; Rich, J; Song, H; Lascola, C; Storms, R; McLendon, R; Reiman, R; Greer, KL; Metzler, SD; McDougald, D; Dai, D; Vaidyanathan, G. Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression. Current Radiopharmaceuticals. 2012;5:47-58. Abstract

Vaidyanathan, G; White, BJ; Affleck, DJ; Zhao, XG; Welsh, PC; McDougald, D; Choi, J; Zalutsky, MR. SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies. Bioorganic & Medicinal Chemistry. 2012;20:6929-6939. Abstract

Vaidyanathan, G; Zalutsky, MR. Applications of 211At and 223Ra in targeted alpha-particle radiotherapy. Current Radiopharmaceuticals. 2011;4:283-294. Abstract

Vaidyanathan, G; McDougald, D; Grasfeder, L; Zalutsky, MR; Chin, B. An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine. Applied Radiation and Isotopes. 2011;69:1401-1406. Abstract

Vaidyanathan, G; Zalutsky, MR. Applications of 211AT and 223RA in targeted alpha-particle radiotherapy. Current Radiopharmaceuticals. 2011;4:283-294.

Vaidyanathan, G; White, B; Affleck, DJ; McDougald, D; Zalutsky, MR. Radioiodinated O(6)-Benzylguanine derivatives containing an azido function. Nuclear Medicine and Biology. 2011;38:77-92. Abstract

Hens, M; Vaidyanathan, G; Zhao, X-G; Bigner, DD; Zalutsky, MR. Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. Nuclear Medicine and Biology. 2010;37:741-750. Abstract

Kato, Y; Vaidyanathan, G; Kaneko, MK; Mishima, K; Srivastava, N; Chandramohan, V; Pegram, C; Keir, ST; Kuan, C-T; Bigner, DD; Zalutsky, MR. Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas. Nuclear Medicine and Biology. 2010;37:785-794. Abstract

Vaidyanathan, G; Affleck, DJ; Zhao, X-G; Keir, ST; Zalutsky, MR. [Lu]-DOTA-Tyr-octreotate: A Potential Targeted Radiotherapeutic for the Treatment of Medulloblastoma. Current Radiopharmaceuticals. 2010;3:29-36. Abstract

Vaidyanathan, G; White, BJ; Zalutsky, MR. Propargyl 4-[F]fluorobenzoate: A Putatively More Stable Prosthetic group for the Fluorine-18 Labeling of Biomolecules via Click Chemistry. Current Radiopharmaceuticals. 2009;2:63-74. Abstract

Vaidyanathan, G; Song, H; Affleck, D; McDougald, DL; Storms, RW; Zalutsky, MR; Chin, BB. Targeting aldehyde dehydrogenase: a potential approach for cell labeling. Nuclear Medicine and Biology. 2009;36:919-929. Abstract

Hens, M; Vaidyanathan, G; Welsh, P; Zalutsky, MR. Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands. Nuclear Medicine and Biology. 2009;36:117-128. Abstract

Vaidyanathan, G; Jestin, E; Olafsen, T; Wu, AM; Zalutsky, MR. Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. Nuclear Medicine and Biology. 2009;36:671-680. Abstract

Vaidyanathan, G; Zalutsky, MR. Astatine Radiopharmaceuticals: Prospects and Problems. Current Radiopharmaceuticals. 2008;1:177. Abstract

Vaidyanathan, G. Meta-iodobenzylguanidine and analogues: chemistry and biology. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2008;52:351-368. Abstract

Rosenkranz, AA; Vaidyanathan, G; Pozzi, OR; Lunin, VG; Zalutsky, MR; Sobolev, AS. Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At. International Journal of Radiation Oncology, Biology, Physics. 2008;72:193-200. Abstract

Vaidyanathan, G; Zalutsky, MR. Synthesis of N-succinimidyl 4-guanidinomethyl-3-[*I]iodobenzoate: a radio-iodination agent for labeling internalizing proteins and peptides. Nature Protocols. 2007;2:282-286. Abstract

Vaidyanathan, G; Affleck, DJ; Alston, KL; Zalutsky, MR. A tin precursor for the synthesis of no-carrier-added [*I]MIBG and [211At]MABG. Journal of Labelled Compounds and Radiopharmaceuticals. 2007;50:177-182.

Vaidyanathan, G; Affleck, DJ; Norman, J; O'Dorisio, S; Zalutsky, MR. A radioiodinated MIBG-octreotate conjugate exhibiting enhanced uptake and retention in SSTR2-expressing tumor cells. Bioconjugate Chemistry. 2007;18:2122-2130. Abstract

Zalutsky, MR; Reardon, DA; Pozzi, OR; Vaidyanathan, G; Bigner, DD. Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies. Nuclear Medicine and Biology. 2007;34:779-785. Abstract

Vaidyanathan, G; Affleck, DJ; Alston, KL; Zhao, X-G; Hens, M; Hunter, DH; Babich, J; Zalutsky, MR. A kit method for the high level synthesis of [211At]MABG. Bioorganic & Medicinal Chemistry. 2007;15:3430-3436. Abstract

Shankar, S; Zalutsky, MR; Friedman, H; Vaidyanathan, G. Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine. Nuclear Medicine and Biology. 2006;33:399-407. Abstract

Vaidyanathan, G; Zalutsky, MR. Synthesis of N-succinimidyl 4-[18F]fluorobenzoate, an agent for labeling proteins and peptides with 18F. Nature Protocols. 2006;1:1655-1661. Abstract

Shankar, S; Vaidyanathan, G; Kuan, C-T; Bigner, DD; Zalutsky, MR. Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance. Nuclear Medicine and Biology. 2006;33:101-110. Abstract

Vaidyanathan, G; Alston, KL; Bigner, DD; Zalutsky, MR. Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies. Bioconjugate Chemistry. 2006;17:1085-1092. Abstract

Vaidyanathan, G; Affleck, DJ; Schottelius, M; Wester, H; Friedman, HS; Zalutsky, MR. Synthesis and evaluation of glycosylated octreotate analogues labeled with radioiodine and 211At via a tin precursor. Bioconjugate Chemistry. 2006;17:195-203. Abstract

Vaidyanathan, G; Zalutsky, MR. Preparation of N-succinimidyl 3-[*I]iodobenzoate: an agent for the indirect radioiodination of proteins. Nature Protocols. 2006;1:707-713. Abstract

Shankar, S; Zalutsky, MR; Vaidyanathan, G. O6-3-[125I]iodobenzyl-2'-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT). Bioorganic & Medicinal Chemistry. 2005;13:3889-3898. Abstract

Vaidyanathan, G; Affleck, DJ; Zalutsky, MR. No-carrier-added synthesis of a 4-methyl-substituted meta-iodobenzylguanidine analogue. Applied Radiation and Isotopes. 2005;62:435-440. Abstract

Vaidyanathan, G. Astatine-211 Labeled Radiopharmaceuticals, invited. Transactions- American Nuclear Society. 2004;91:856-.

Vaidyanathan, G; Affleck, DJ; Alston, KL; Welsh, P; Zalutsky, MR. Catabolism of 4-fluoro-3-iodobenzylguanidine and meta-iodobenzylguanidine by SK-N-SH neuroblastoma cells. Nuclear Medicine Communications. 2004;25:947-955. Abstract

Boyd, M; Mairs, RJ; Keith, WN; Ross, SC; Welsh, P; Akabani, G; Owens, J; Vaidyanathan, G; Carruthers, R; Dorrens, J; Zalutsky, MR. An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects. The Journal of Gene Medicine. 2004;6:937-947. Abstract

Vaidyanathan, G; Boskovitz, A; Shankar, S; Zalutsky, MR. Radioiodine and 211At-labeled guanidinomethyl halobenzoyl octreotate conjugates: potential peptide radiotherapeutics for somatostatin receptor-positive cancers. Peptides. 2004;25:2087-2097. Abstract

Vaidyanathan, G; Zalutsky, MR. Imaging drug resistance with radiolabeled molecules. Current Pharmaceutical Design. 2004;10:2965-2979. Abstract

Vaidyanathan, G; Affleck, DJ; Norman, J; Welsh, P; Liu, W; Johnson, SP; Friedman, HS; Zalutsky, MR. O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase. Bioconjugate Chemistry. 2004;15:402-408. Abstract

Shankar, S; Vaidyanathan, G; Affleck, DJ; Peixoto, K; Bigner, DD; Zalutsky, MR. Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent. Nuclear Medicine and Biology. 2004;31:909-919. Abstract

Vaidyanathan, G; Welsh, PC; Vitorello, KC; Snyder, S; Friedman, HS; Zalutsky, MR. A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells. European Journal of Nuclear Medicine and Molecular Imaging. 2004;31:1362-1370. Abstract

Vaidyanathan, G; Shankar, S; Affleck, DJ; Alston, K; Norman, J; Welsh, P; LeGrand, H; Zalutsky, MR. Meta-iodobenzylguanidine derivatives containing a second guanidine moiety. Bioorganic & Medicinal Chemistry. 2004;12:1649-1656. Abstract

Vaidyanathan, G; Friedman, HS; Affleck, DJ; Schottelius, M; Wester, H-J; Zalutsky, MR. Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003;9:1868-1876. Abstract

Vaidyanathan, G; Affleck, DJ; Bigner, DD; Zalutsky, MR. N-succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: an acylation agent for labeling internalizing antibodies with alpha-particle emitting 211At. Nuclear Medicine and Biology. 2003;30:351-359. Abstract

Shankar, S; Vaidyanathan, G; Affleck, D; Welsh, PC; Zalutsky, MR. N-succinimidyl 3-[(131)I]iodo-4-phosphonomethylbenzoate ([(131)I]SIPMB), a negatively charged substituent-bearing acylation agent for the radioiodination of peptides and mAbs. Bioconjugate Chemistry. 2003;14:331-341. Abstract

Vaidyanathan, G; Affleck, DJ; Bigner, DD; Zalutsky, MR. Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate. Nuclear Medicine and Biology. 2002;29:1-11. Abstract

Vaidyanathan, G; Shankar, S; Zalutsky, MR. Synthesis of ring- and side-chain-substituted m-iodobenzylguanidine analogues. Bioconjugate Chemistry. 2001;12:786-797. Abstract

Vaidyanathan, G; Shankar, S; Affleck, DJ; Welsh, PC; Slade, SK; Zalutsky, MR. Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues. Bioconjugate Chemistry. 2001;12:798-806. Abstract

Vaidyanathan, G; Affleck, DJ; Li, J; Welsh, P; Zalutsky, MR. A polar substituent-containing acylation agent for the radioiodination of internalizing monoclonal antibodies: N-succinimidyl 4-guanidinomethyl-3-[131I]iodobenzoate ([131I]SGMIB). Bioconjugate Chemistry. 2001;12:428-438. Abstract

Vaidyanathan, G; Affleck, DJ; Cavazos, CM; Johnson, SP; Shankar, S; Friedman, HS; Colvin, MO; Zalutsky, MR. Radiolabeled guanine derivatives for the in vivo mapping of O(6)-alkylguanine-DNA alkyltransferase: 6-(4-[(18)F]Fluoro-benzyloxy)-9H-purin-2-ylamine and 6-(3-[(131)I]Iodo-benzyloxy)-9H-purin-2-ylamine. Bioconjugate Chemistry. 2000;11:868-875. Abstract

Zalutsky, MR; Vaidyanathan, G. Astatine-211-labeled radiotherapeutics: an emerging approach to targeted alpha-particle radiotherapy. Current Pharmaceutical Design. 2000;6:1433-1455. Abstract

Vaidyanathan, G; Affleck, D; Welsh, P; Srinivasan, A; Schmidt, M; Zalutsky, MR. Radioiodination and astatination of octreotide by conjugation labeling. Nuclear Medicine and Biology. 2000;27:329-337. Abstract

Vaidyanathan, G; Srinivasan, A; Affleck, DJ; Welsh, PC; Slade, SK; Schmidt, MA; Zalutsky, MR. Octreotide analogues labeled with radioiodine and astatine-211. 1999;42:S33-S35.

Cunningham, SH; Mairs, RJ; Wheldon, TE; Welsh, PC; Vaidyanathan, G; Zalutsky, MR. Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissions. British Journal of Cancer. 1998;77:2061-2068. Abstract

Walicka, MA; Vaidyanathan, G; Zalutsky, MR; Adelstein, SJ; Kassis, AI. Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. Radiation Research. 1998;150:263-268. Abstract

Vaidyanathan, G; Zalutsky, MR; DeGrado, TR. Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. Bioconjugate Chemistry. 1998;9:758-764. Abstract

Vaidyanathan, G; Zalutsky, MR. Preparation of 5-[131I]iodo- and 5-[211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction. Nuclear Medicine and Biology. 1998;25:487-496. Abstract

DeGrado, TR; Zalutsky, MR; Coleman, RE; Vaidyanathan, G. Effects of specific activity on meta-[(131)I]iodobenzylguanidine kinetics in isolated rat heart. Nuclear Medicine and Biology. 1998;25:59-64. Abstract

Larsen, RH; Vaidyanathan, G; Zalutsky, MR. Cytotoxicity of alpha-particle-emitting 5-[211At]astato-2'-deoxyuridine in human cancer cells. International Journal of Radiation Biology (Informa). 1997;72:79-90. Abstract

Vaidyanathan, G; Affleck, DJ; Zalutsky, MR. Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate. Bioconjugate Chemistry. 1997;8:724-729. Abstract

Vaidyanathan, G; Zhao, X-G; Larsen, RH; Zalutsky, MR. 3-[211At]astato-4-fluorobenzylguanidine: A potential therapeutic agent with prolonged retention by neuroblastoma cells. 1997;76:226-233.

Vaidyanathan, G; Zalutsky, MR. Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue. Nuclear Medicine and Biology. 1997;24:171-178. Abstract

Vaidyanathan, G; Zalutsky, MR. Fluorine-18-labeled [Nle4,D-Phe7]-¿-MSH, an ¿-melanocyte stimulating hormone analogue. Nuclear Medicine and Biology. 1997;24:171-178.

Vaidyanathan, G; Zhao, XG; Strickland, DK; Zalutsky, MR. No-carrier-added iodine-131-FIBG: evaluation of an MIBG analog. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997;38:330-334. Abstract

Vaidyanathan, G; Affleck, DJ; Zalutsky, MR. No-carrier-added (4-fluoro-3-[131I]iodobenzyl)guanidine and (3-[211At]astato-4-fluorobenzyl)guanidine. Bioconjugate Chemistry. 1996;7:102-107. Abstract

Vaidyanathan, G; Zalutsky, MR. Targeted therapy using alpha emitters. Physics in Medicine and Biology. 1996;41:1915-1931. Abstract

Vaidyanathan, G; Friedman, HS; Keir, ST; Zalutsky, MR. Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model. Nuclear Medicine and Biology. 1996;23:851-856. Abstract

Vaidyanathan, G; Friedman, HS; Keir, ST; Zalutsky, MR. Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity. British Journal of Cancer. 1996;73:1171-1177. Abstract

Vaidyanathan, G; Larsen, RH; Zalutsky, MR. 5-[211 At]astato-2'-deoxyuridine, an alpha particle-emitting endoradiotherapeutic agent undergoing DNA incorporation. Cancer Research. 1996;56:1204-1209. Abstract

Reist, CJ; Archer, GE; Kurpad, SN; Wikstrand, CJ; Vaidyanathan, G; Willingham, MC; Moscatello, DK; Wong, AJ; Bigner, DD; Zalutsky, MR. Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. Cancer Research. 1995;55:4375-4382. Abstract

Vaidyanathan, G; Affleck, DJ; Zalutsky, MR. Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1995;36:644-650. Abstract

Johnson, EL; Turkington, TG; Jaszczak, RJ; Gilland, DR; Vaidyanathan, G; Greer, KL; Coleman, RE; Zalutsky, MR. Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models. Nuclear Medicine and Biology. 1995;22:45-54. Abstract

Vaidyanathan, G; Zalutsky, MR. No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation. Nuclear Medicine and Biology. 1995;22:61-64. Abstract

Degrado, TR; Zalutsky, MR; Vaidyanathan, G. Uptake mechanisms of meta-[123I]iodobenzylguanidine in isolated rat heart. Nuclear Medicine and Biology. 1995;22:1-12. Abstract

Strickland, DK; Vaidyanathan, G; Friedman, HS; Zalutsky, MR. Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines. Journal of Neuro-Oncology. 1995;25:9-17.

Vaidyanathan, G; Zalutsky, MR. Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. Nuclear Medicine and Biology. 1995;22:759-764. Abstract

Mairs, RJ; Russell, J; Cunningham, S; O'Donoghue, JA; Gaze, MN; Owens, J; Vaidyanathan, G; Zalutsky, MR. Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [131I]meta-iodobenzylguanidine: implications for the targeted radiotherapy of neuroblastoma. European Journal of Cancer. 1995;31A:576-581. Abstract

Vaidyanathan, G; Affleck, DJ; Zalutsky, MR. (4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography. Journal of Medicinal Chemistry. 1994;37:3655-3662. Abstract

Page, RL; Garg, PK; Vaidyanathan, G; Zalutsky, MR. Preclinical evaluation and PET imaging of 18F-labeled Mel-14 F(ab')2 fragment in normal dogs. Nuclear Medicine and Biology. 1994;21:911-919. Abstract

Vaidyanathan, G; Affleck, D; Zalutsky, MR. Monoclonal antibody F(ab')2 fragment labeled with N-succinimidyl 2,4-dimethoxy-3-halobenzoates: in vivo comparison of iodinated and astatinated fragments. Nuclear Medicine and Biology. 1994;21:105-110. Abstract

Gaze, MN; Mairs, RJ; Vaidyanathan, G; Zalutsky, MR. Synthesis of carrier-free 131I-meta-iodobenzyl-guanidine by novel routes to enhance therapeutic efficiency in neuroblastoma. Progress in Clinical and Biological Research. 1994;385:347-353. Abstract

Vaidyanathan, G; Strickland, DK; Zalutsky, MR. Meta-[211At]astatobenzylguanidine: Further evaluation of a potential therapeutic agent. International Journal of Cancer. 1994;57:908-913.

Vaidyanathan, G; Zalutsky, MR. Improved synthesis of N-succinimidyl 4-[18F]fluorobenzoate and its application to the labeling of a monoclonal antibody fragment. Bioconjugate Chemistry. 1994;5:352-356. Abstract

Mairs, RJ; Gaze, MN; Watson, DG; Skellern, GG; Constable, P; McKellar, K; Owens, J; Vaidyanathan, G; Zalutsky, MR. Carrier-free 131I-meta-iodobenzylguanidine: comparison of production from meta-diazobenzylguanidine and from meta-trimethylsilylbenzylguanidine. Nuclear Medicine Communications. 1994;15:268-274. Abstract

Vaidyanathan, G; Strickland, DK; Zalutsky, MR. Meta-[211At]astatobenzylguanidine: further evaluation of a potential therapeutic agent. International Journal of Cancer. 1994;57:908-913. Abstract

Strickland, DK; Vaidyanathan, G; Zalutsky, MR. Cytotoxicity of alpha-particle-emitting m-[211At]astatobenzylguanidine on human neuroblastoma cells. Cancer Research. 1994;54:5414-5419. Abstract

Turkington, TG; Zalutsky, MR; Jaszczak, RJ; Garg, PK; Vaidyanathan, G; Coleman, RE. Measuring astatine-211 distributions with SPECT. Physics in Medicine and Biology. 1993;38:1121-1130. Abstract

Vaidyanathan, G; Zalutsky, MR. No-carrier-added synthesis of meta-[131I]iodobenzylguanidine. Applied Radiation and Isotopes. 1993;44:621-628. Abstract

Vaidyanathan, G; Affleck, DJ; Zalutsky, MR. Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate. Bioconjugate Chemistry. 1993;4:78-84. Abstract

Vaidyanathan, G; Bigner, DD; Zalutsky, MR. Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1992;33:1535-1541. Abstract

Vaidyanathan, G; Zalutsky, MR. Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate. International Journal of Radiation Applications and Instrumentation.. 1992;19:275-281. Abstract

Vaidyanathan, G; Jay, M; Bera, RK; Mayer, PR; Brazzell, RK. Scintigraphic evaluation of the ocular disposition of 18F-imirestat in rabbits. Pharmaceutical Research. 1990;7:1198-1200. Abstract

Vaidyanathan, G; Zalutsky, MR. Radioiodination of antibodies via N-succinimidyl 2,4-dimethoxy-3-(trialkylstannyl)benzoates. Bioconjugate Chemistry. 1990;1:387-393. Abstract

Vaidyanathan, G; Zalutsky, MR. Protein radiohalogenation: observations on the design of N-succinimidyl ester acylation agents. Bioconjugate Chemistry. 1990;1:269-273. Abstract

Vaidyanathan, G; Wilson, JW. Reaction of cyclopropanamines with hypochlorite. The Journal of Organic Chemistry. 1989;54:1815-1820.

Vaidyanathan, G; Wilson, JW. Decarboxylation of 1-aminocyclopropanecarboxylic acid and its derivatives. The Journal of Organic Chemistry. 1989;54:1810-1815.