James Bowsher, PhD

Adjunct Associate Professor in the Department of Radiation Oncology
Department: Radiation Oncology
Division: Radiation Physics
Address: Duke Clinics Bldg -- 200 Trent Dr.
04207 Red Zone -- Basement
Durham, NC 27710
Office Phone: (919) 660-2120
Email: james.bowsher@dukekunshan.edu.cn

Research Interests

Dr. Bowsher's research interests include functional and molecular imaging in radiation therapy, particularly positron emission tomography and single-photon emission computed tomography; imaging onboard radiation therapy machines; robotics and imaging; region-of-interest methods for high-resolution, high-sensitivity imaging; methods for integrating multiple imaging modalities -- and realistic system modeling -- into the generation of medical images; and quality assurance methods for imaging and for other radiation therapy systems.

Publications

McGurk, RJ; Bowsher, J; Lee, JA; Das, SK. Combining multiple FDG-PET radiotherapy target segmentation methods to reduce the effect of variable performance of individual segmentation methods. 2013;40:042501. Abstract

McGurk, RJ; Smith, VA; Bowsher, J; Lee, JA; Das, SK. Influence of filter choice on 18F-FDG PET segmentation accuracy determined using generalized estimating equations. Physics in Medicine and Biology. 2013;58:3517-3534. Abstract

Laymon, CM; Bowsher, JE. Anomaly Detection and Artifact Recovery in PET Attenuation-Correction Images Using the Likelihood Function. 2013;7:137-146. Abstract

Turner, RA; Wauthier, E; Lozoya, O; McClelland, R; Bowsher, JE; Barbier, C; Prestwich, G; Hsu, E; Gerber, DA; Reid, LM. Successful transplantation of human hepatic stem cells with restricted localization to liver using hyaluronan grafts. Hepatology. 2013;57:775-784. Abstract

Li, H; Giles, W; Bowsher, J; Yin, F-F. A dual cone-beam CT system for image guided radiotherapy: initial performance characterization. Medical physics. 2013;40:021912. Abstract

Roper, JR; Bowsher, JE; Wilson, JM; Turkington, TG; Yin, F-F. Target localization using scanner-acquired SPECT data. Journal of applied clinical medical physics / American College of Medical Physics. 2012;13:3724. Abstract

Chang, Z; Wu, Q; Adamson, J; Ren, L; Bowsher, J; Yan, H; Thomas, A; Yin, F-F. Commissioning and dosimetric characteristics of TrueBeam system: composite data of three TrueBeam machines. Medical physics. 2012;39:6981-7018. Abstract

Chang, Z; Bowsher, J; Cai, J; Yoo, S; Wang, Z; Adamson, J; Ren, L; Yin, F-F. Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: Our 1 year experience. Journal of applied clinical medical physics / American College of Medical Physics. 2012;13:113-140.

Li, H; Giles, W; Ren, L; Bowsher, J; Yin, F-F. Implementation of dual-energy technique for virtual monochromatic and linearly mixed CBCTs. Medical physics. 2012;39:6056-6064. Abstract

Giles, W; Bowsher, J; Li, H; Yin, F-F. Interleaved acquisition for cross scatter avoidance in dual cone-beam CT. Medical physics. 2012;39:7719-7728. Abstract

Giles, W; Bowsher, J; Li, H; Yin, F-F. Crescent artifacts in cone-beam CT. Medical physics. 2011;38:2116-2121. Abstract

Roper, J; Bowsher, J; Yin, F-F. Direction-dependent localization errors in SPECT images. Medical physics. 2010;37:4886-4896. Abstract

Thomas, A; Bowsher, J; Roper, J; Oliver, T; Dewhirst, M; Oldham, M. A comprehensive method for optical-emission computed tomography. Physics in Medicine and Biology. 2010;55:3947-3957. Abstract

Roper, J; Bowsher, J; Yin, F-F. On-board SPECT for localizing functional targets: a simulation study. Medical physics. 2009;36:1727-1735. Abstract

Song, H; Bowsher, J; Das, S; Yin, F-F. Tracking brachytherapy sources using emission imaging with one flat panel detector. Medical physics. 2009;36:1109-1111. Abstract

Madhav, P; Bowsher, JE; Cutler, SJ; Tornai, MP. Characterizing the MTF in 3D for a Quantized SPECT Camera Having Arbitrary Trajectories. IEEE Transactions on Nuclear Science. 2009;56:661-670. Abstract

Ter-Antonyan, R; Jaszczak, RJ; Greer, KL; Bowsher, JE; Metzler, SD; Coleman, RE. Combination of converging collimators for high-sensitivity brain SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2009;50:1548-1556. Abstract

Kim, E; Bowsher, J; Thomas, AS; Sakhalkar, H; Dewhirst, M; Oldham, M. Improving the quantitative accuracy of optical-emission computed tomography by incorporating an attenuation correction: application to HIF1 imaging. Physics in Medicine and Biology. 2008;53:5371-5383. Abstract

Ter-Antonyan, R; Jaszczak, RJ; Bowsher, JE; Greer, KL; Metzler, SD. Quantitative Evaluation of Half-Cone-Beam Scan Paths in Triple-Camera Brain SPECT. IEEE Transactions on Nuclear Science. 2008;55:2518-2526. Abstract

Chang, Z; Wang, Z; Wu, QJ; Yan, H; Bowsher, J; Zhang, J; Yin, F-F. Dosimetric characteristics of novalis Tx system with high definition multileaf collimator. Medical physics. 2008;35:4460-4463. Abstract

Metzler, SD; Jaszczak, RJ; Greer, KL; Bowsher, JE. Angular-dependent axial-shift correction for pinhole SPECT. IEEE Transactions on Nuclear Science. 2007;54:124-129.

Ter-Antonyan, R; Jaszczak, RJ; Bowsher, JE; Greer, KL; Metzler, SD. Brain SPECT Simulation Using Half-Cone-Beam Collimation and Single-Revolution Helical-Path Acquisition. IEEE Transactions on Nuclear Science. 2007;54:475-479. Abstract

Brzymialkiewicz, CN; Tornai, MP; McKinley, RL; Cutler, SJ; Bowsher, JE. Performance of dedicated emission mammotomography for various breast shapes and sizes. Physics in Medicine and Biology. 2006;51:5051-5064. Abstract

Yuan, H; Schroeder, T; Bowsher, JE; Hedlund, LW; Wong, T; Dewhirst, MW. Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2006;47:989-998. Abstract

McKinley, RL; Tornai, MP; Brzymialkiewicz, C; Madhav, P; Samei, E; Bowsher, JE. Analysis of a novel offset cone-beam computed mammotomography system geometry for accomodating various breast sizes. Physica Medica. 2006;21 Suppl 1:48-55. Abstract

Bobkov, KV; Bowsher, JE; Greer, KL; Jaszczak, RJ; Braun, KE; Lee, TJ. Phantom assessment of new acquisition geometries for breast pinhole SPECT imaging. IEEE Transactions on Nuclear Science. 2006;53:1162-1167.

Bowsher, JE; DeLong, DM; Turkington, TG; Jaszczak, RJ. Aligning emission tomography and MRI images by optimizing the emission-tomography image reconstruction objective function. IEEE Transactions on Nuclear Science. 2006;53:1248-1258.

Akabani, G; Reardon, DA; Coleman, RE; Wong, TZ; Metzler, SD; Bowsher, JE; Barboriak, DP; Provenzale, JM; Greer, KL; DeLong, D; Friedman, HS; Friedman, AH; Zhao, X-G; Pegram, CN; McLendon, RE; Bigner, DD; Zalutsky, MR. Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2005;46:1042-1051. Abstract

Tornai, MP; Brzymialkiewicz, CN; Bradshaw, ML; Bowsher, JE; Patt, BE; Iwanczyk, JS; Li, J; MacDonald, LR. Comparison of compact gamma cameras with 1.3- And 2.0-mm quantized elements for dedicated emission mammotomography. IEEE Transactions on Nuclear Science. 2005;52:1251-1256.

Brzymialkiewicz, CN; Tornai, MP; McKinley, RL; Bowsher, JE. Evaluation of fully 3-D emission mammotomography with a compact cadmium zinc telluride detector. IEEE Transactions on Medical Imaging. 2005;24:868-877. Abstract

Rizzieri, DA; Akabani, G; Zalutsky, MR; Coleman, RE; Metzler, SD; Bowsher, JE; Toaso, B; Anderson, E; Lagoo, A; Clayton, S; Pegram, CN; Moore, JO; Gockerman, JP; DeCastro, C; Gasparetto, C; Chao, NJ; Bigner, DD. Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma. Blood. 2004;104:642-648. Abstract

Tornai, MP; Bowsher, JE; Archer, CN; Peter, J; Jaszczak, RJ; MacDonald, LR; Patt, BE; Iwanczyk, JS. A 3D gantry single photon emission tomograph with hemispherical coverage for dedicated breast imaging. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2003;497:157-167.

Tornai, MP; Bowsher, JE; Jaszczak, RJ; Pieper, BC; Greer, KL; Hardenbergh, PH; Coleman, RE. Mammotomography with pinhole incomplete circular orbit SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2003;44:583-593. Abstract

Metzler, SD; Bowsher, JE; Jaszczak, RJ. Geometrical Similarities of the Orlov and Tuy Sampling Criteria and a Numerical Algorithm for Assessing Sampling Completeness. 2003;50:1550-1555.

Archer, CN; Tornai, MP; Bowsher, JE; Metzler, SD; Pieper, BC; Jaszczak, RJ. Implementation and initial characterization of acquisition orbits with a dedicated emission mammotomograph. IEEE Transactions on Nuclear Science. 2003;50:413-420.

Gilland, DR; Mair, BA; Bowsher, JE; Jaszczak, RJ. Simultaneous reconstruction and motion estimation for gated cardiac ECT. 2002;49 I:2344-2349.

Bowsher, JE; Tornai, MP; Peter, J; González Trotter, DE; Krol, A; Gilland, DR; Jaszczak, RJ. Modeling the axial extension of a transmission line source within iterative reconstruction via multiple transmission sources. IEEE Transactions on Medical Imaging. 2002;21:200-215. Abstract

Chen, M; Bowsher, JE; Baydush, AH; Gilland, KL; DeLong, DM; Jaszczak, RJ. Using the Hotelling observer on multislice and multiview simulated SPECT myocardial images. IEEE Transactions on Nuclear Science. 2002;49 I:661-667.

Chen, M; Peter, J; Jaszczak, RJ; Gilland, DR; Bowsher, JE; Tornai, MP; Metzler, SD. Observer studies of cardiac lesion detectability with triple-head 360° versus dual-head 180° SPECT acquisition using simulated projection data. IEEE Transactions on Nuclear Science. 2002;49 I:655-660.

Metzler, SD; Bowsher, JE; Greer, KL; Jaszczak, RJ. Analytic determination of the pinhole collimator's point-spread function and RMS resolution with penetration. IEEE Transactions on Medical Imaging. 2002;21:878-887. Abstract

Pieper, BC; Bowsher, JE; Tornai, MP; Archer, CN; Jaszczak, RJ. Parallel-beam tilted-head analytic SPECT reconstruction: Derivation and comparison with OSEM. 2002;49 I:2394-2400.

Metzler, SD; Bowsher, JE; Tornai, MP; Pieper, BC; Peter, J; Jaszczak, RJ. SPECT breast imaging combining horizontal and vertical axes of rotation. IEEE Transactions on Nuclear Science. 2002;49:31-36.

Metzler, SD; Bowsher, JE; Smith, MF; Jaszczak, RJ. Analytic determination of pinhole collimator sensitivity with penetration. IEEE Transactions on Medical Imaging. 2001;20:730-741. Abstract

Chen, M; Jaszczak, RJ; Bowsher, JE; Gilland, DR. An evaluation of cardiac uniformity, contrast, and SNR with dual-head 180° and triple-head 360° SPECT scans. IEEE Transactions on Nuclear Science. 2001;48:1428-1434.

Trotter, DEG; Bowsher, JE; Jaszczak, RJ. Absolute quantitation of a spherical I-131 activity distribution using a high-resolution rotating collimator: A phantom study. 2001;48:65-73.

Pieper, BC; Bowsher, JE; Tornai, MP; Peter, J; Greer, K; Jaszczak, RJ. Breast tumor imaging using a tiltable head SPECT camera. IEEE Transactions on Nuclear Science. 2001;48:1477-1482.

Trotter, DEG; Jaszczak, RJ; Bowsher, JE; Akabani, G; Greer, KL. High-resolution absolute SPECT quantitation for I-131 distributions used in the treatment of lymphoma: A phantom study. 2001;48:707-714.

Krol, A; Bowsher, JE; Manglos, SH; Feiglin, DH; Tornai, MP; Thomas, FD. An EM algorithm for estimating SPECT emission and transmission parameters from emissions data only. IEEE Transactions on Medical Imaging. 2001;20:218-232. Abstract

Baydush, AH; Bowsher, JE; Laading, JK; Floyd, CE. Improved Bayesian image estimation for digital chest radiography. Medical physics. 1997;24:539-545. Abstract

Higdon, DM; Bowsher, JE; Johnson, VE; Turkington, TG; Gilland, DR; Jaszczak, RJ. Fully Bayesian estimation of Gibbs hyperparameters for emission computed tomography data. IEEE Transactions on Medical Imaging. 1997;16:516-526. Abstract

Bowsher, JE; Johnson, VE; Turkington, TG; Jaszczak, RJ; Floyd, CR; Coleman, RE. Bayesian reconstruction and use of anatomical a priori information for emission tomography. IEEE Transactions on Medical Imaging. 1996;15:673-686. Abstract

GILLAND, DR; JASZCZAK, RJ; BOWSHER, JE; GREER, KL; COLEMAN, RE. MEASURED ACCURACY AND PRECISION IN QUANTITATIVE SPECT IMAGING WITH I-123. IEEE Transactions on Nuclear Science. 1995;42:1120-1125.

Floyd, CE; Baydush, AH; Lo, JY; Bowsher, JE; Ravin, CE. Bayesian restoration of chest radiographs. Scatter compensation with improved signal-to-noise ratio. Investigative Radiology. 1994;29:904-910. Abstract

Floyd, CE; Baydush, AH; Lo, JY; Bowsher, JE; Ravin, CE. Scatter compensation for digital chest radiography using maximum likelihood expectation maximization. Investigative Radiology. 1993;28:427-433. Abstract

Gilland, DR; Jaszczak, RJ; Bowsher, JE; Turkington, TG; Liang, Z; Greer, KL. Quantitative SPECT brain imaging: effects of attenuation and detector response. 1993;40:295-299.

Bowsher, JE; Clegg, TB; Karwowski, HJ; Ludwig, EJ; Thompson, WJ; Tostevin, JA. Effects of 6Li excitation in 64Zn(d. Physical Review C - Nuclear Physics. 1992;45:2824-2835. Abstract

Munley, MT; Jr, CEF; Tourassi, GD; Bowsher, JE; Coleman, RE. Out-of-plane photons in SPECT. 1991;38:776-779.

Tourassi, GD; Jr, CEF; Munley, MT; Bowsher, JE; Coleman, RE. Improved lesion detection in SPECT using MLEM reconstruction. 1991;38:780-783.

Bowsher, JE; Floyd, CE. Treatment of Compton scattering in maximum-likelihood, expectation-maximization reconstructions of SPECT images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1991;32:1285-1291. Abstract

FLOYD, CE; MUNLEY, MT; TOURASSI, GD; BOWSHER, JE. DUAL COLLIMATION ACQUISITION FOR HIGH-RESOLUTION, LOW-NOISE SPECT. IEEE Transactions on Nuclear Science. 1991;38:784-788.

Bhat, CM; Bowsher, JE; Clegg, TB; Karwowski, HJ; Ludwig, EJ; Brown, BA. Single-nucleon pickup spectroscopic factors for levels in 30Si and 30P and the D state of three-nucleon systems. Physical Review C - Nuclear Physics. 1988;38:1537-1546. Abstract

KARP, BC; LUDWIG, EJ; BOWSHER, JE; BURKS, BL; CLEGG, TB; SANTOS, FD; EIRO, AM. ALPHA-PARTICLE D-STATE AND CONFIGURATION-MIXING EFFECTS IN THE Y-89(D,ALPHA)SR-87 REACTION. Nuclear Physics A. 1986;457:15-44.

Santos, FD; Karp, BC; Bowsher, JE; Ludwig, EJ; Eiró, AM. Determination of two-nucleon spectroscopic amplitudes from (d, alpha ) analyzing powers. Physical Review C - Nuclear Physics. 1985;32:338-341. Abstract