Oana Craciunescu, PhD

Associate Professor of Radiation Oncology
Department: Radiation Oncology
Division: Radiation Physics
Address: 201 Trent Drive
Box 3295
Durham, NC 27710
Office Phone: (919) 660-2192
Email: oana.craciunescu@duke.edu

Research Interests

MR-based brachytherapy planning, adaptive planning for gynecological malignancies, MR perfusion imaging, MR prognostic factors, Imaging tools to evaluate treatment response, modeling and planing for hyperthermia,



Publications

Cabrera, AR; Cuneo, KC; Desjardins, A; Sampson, JH; McSherry, F; II, JEH; Peters, KB; Allen, K; Hoang, JK; Chang, Z; Craciunescu, O; Vredenburgh, JJ; Friedman, HS; Kirkpatrick, JP. Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: A prospective trial. International Journal of Radiation Oncology, Biology, Physics. 2013;86:873-879.

Cabrera, AR; Cuneo, KC; Desjardins, A; Sampson, JH; McSherry, F; Herndon, JE; Peters, KB; Allen, K; Hoang, JK; Chang, Z; Craciunescu, O; Vredenburgh, JJ; Friedman, HS; Kirkpatrick, JP. Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: a prospective trial. International Journal of Radiation: Oncology - Biology - Physics. 2013;86:873-879. Abstract

Yuan, Y; Wyatt, C; Maccarini, P; Stauffer, P; Craciunescu, O; Macfall, J; Dewhirst, M; Das, SK. A heterogeneous human tissue mimicking phantom for RF heating and MRI thermal monitoring verification. Physics in Medicine and Biology. 2012;57:2021-2037. Abstract

Adamson, J; Newton, J; Yang, Y; Steffey, B; Cai, J; Adamovics, J; Oldham, M; Chino, J; Craciunescu, O. Commissioning a CT-compatible LDR tandem and ovoid applicator using Monte Carlo calculation and 3D dosimetry. Medical physics. 2012;39:4515-4523. Abstract

Craciunescu, OI; Yoo, DS; Cleland, E; Muradyan, N; Carroll, MD; MacFall, JR; Barboriak, DP; Brizel, DM. Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters. International Journal of Radiation: Oncology - Biology - Physics. 2012;82:e345-e350. Abstract

Arunachalam, K; Craciunescu, OI; Markewitz, EJ; Maccarini, PF; Schlorff, JL; Stauffer, PR. Preclinical assessment of comfort and secure fit of thermobrachytherapy surface applicator (TBSA) on volunteer subjects. Journal of applied clinical medical physics / American College of Medical Physics. 2012;13:3845. Abstract

Yuan, Y; Cheng, K-S; Craciunescu, OI; Stauffer, PR; Maccarini, PF; Arunachalam, K; Vujaskovic, Z; Dewhirst, MW; Das, SK. Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma. Medical physics. 2012;39:1170-1181. Abstract

Yoo, DS; Kirkpatrick, JP; Craciunescu, O; Broadwater, G; Peterson, BL; Carroll, MD; Clough, R; MacFall, JR; Hoang, J; Scher, RL; Esclamado, RM; Dunphy, FR; Ready, NE; Brizel, DM. Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012;18:1404-1414. Abstract

Arunachalam, K; Craciunescu, OI; Markewitz, EJ; Maccarini, PF; Schlorff, JL; Stauffer, PR. Preclinical assessment of comfort and secure fit of thermobrachytherapy surface applicator (TBSA) on volunteer subjects. Journal of applied clinical medical physics / American College of Medical Physics. 2012;13:223-235.

Li, Z; Vogel, M; Maccarini, PF; Stakhursky, V; Soher, BJ; Craciunescu, OI; Das, S; Arabe, OA; Joines, WT; Stauffer, PR. Improved hyperthermia treatment control using SAR/temperature simulation and PRFS magnetic resonance thermal imaging. International Journal of Hyperthermia (Informa). 2011;27:86-99. Abstract

Kelsey, CR; Horwitz, ME; Chino, JP; Craciunescu, O; Steffey, B; Folz, RJ; Chao, NJ; Rizzieri, DA; Marks, LB. Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors. International Journal of Radiation: Oncology - Biology - Physics. 2011;81:812-818. Abstract

Craciunescu, OI; Steffey, BA; Kelsey, CR; Larrier, NA; Paarz-Largay, CJ; Prosnitz, RG; Chao, N; Chute, J; Gasparetto, C; Horwitz, M; Long, G; Rizzieri, D; Sullivan, KM. Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial. International Journal of Radiation: Oncology - Biology - Physics. 2011;79:1248-1255. Abstract

McMahon, R; Zhuang, T; Steffey, BA; Song, H; Craciunescu, OI. Commissioning of Varian ring & tandem HDR applicators: reproducibility and interobserver variability of dwell position offsets. Journal of applied clinical medical physics / American College of Medical Physics. 2011;12:3447. Abstract

McMahon, R; Zhuang, T; Steffey, BA; Song, H; Craciunescu, OI. Commissioning of Varian ring & tandem HDR applicators: Reproducibility and interobserver variability of dwell position offsets. Journal of applied clinical medical physics / American College of Medical Physics. 2011;12:50-62.

Stauffer, PR; Maccarini, P; Arunachalam, K; Craciunescu, O; Diederich, C; Juang, T; Rossetto, F; Schlorff, J; Milligan, A; Hsu, J; Sneed, P; Vujaskovic, Z. Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence. International Journal of Hyperthermia (Informa). 2010;26:686-698. Abstract

Craciunescu, O; Brizel, D; Cleland, E; Yoo, D; Muradyan, N; Carroll, M; Barboriak, D; MacFall, J. Dynamic contrast enhanced-MRI in head and neck cancer patients: variability of the precontrast longitudinal relaxation time (T10). Medical physics. 2010;37:2683-2692. Abstract

Pierquet, M; Craciunescu, O; Steffey, B; Song, H; Oldham, M. On the Feasibility of Verification of 3D Dosimetry Near Brachytherapy Sources Using PRESAGE/Optical-CT. Journal of Physics. 2010;250:120911-120915. Abstract

Arunachalam, K; Maccarini, PF; Craciunescu, OI; Schlorff, JL; Stauffer, PR. Thermal characteristics of thermobrachytherapy surface applicators for treating chest wall recurrence. Physics in Medicine and Biology. 2010;55:1949-1969. Abstract

Craciunescu, OI; Thrall, DE; Vujaskovic, Z; Dewhirst, MW. Magnetic resonance imaging: a potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer. International Journal of Hyperthermia (Informa). 2010;26:625-637. Abstract

Vujaskovic, Z; Kim, DW; Jones, E; Lan, L; McCall, L; Dewhirst, MW; Craciunescu, O; Stauffer, P; Liotcheva, V; Betof, A; Blackwell, K. A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer. International Journal of Hyperthermia (Informa). 2010;26:514-521. Abstract

Craciunescu, OI; Stauffer, PR; Soher, BJ; Wyatt, CR; Arabe, O; Maccarini, P; Das, SK; Cheng, K-S; Wong, TZ; Jones, EL; Dewhirst, MW; Vujaskovic, Z; MacFall, JR. Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. Medical physics. 2009;36:4848-4858. Abstract

Craciunescu, OI; Blackwell, KL; Jones, EL; Macfall, JR; Yu, D; Vujaskovic, Z; Wong, TZ; Liotcheva, V; Rosen, EL; Prosnitz, LR; Samulski, TV; Dewhirst, MW. DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study. International Journal of Hyperthermia (Informa). 2009;25:405-415. Abstract

Das, SK; Macfall, J; McCauley, R; Craciunescu, O; Dewhirst, MW; Samulski, TV. Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data. International Journal of Hyperthermia (Informa). 2005;21:657-667. Abstract

Das, SK; Baydush, AH; Zhou, S; Miften, M; Yu, X; Craciunescu, O; Oldham, M; Light, K; Wong, T; Blazing, M; Borges-Neto, S; Dewhirst, MW; Marks, LB. Predicting radiotherapy-induced cardiac perfusion defects. Medical physics. 2005;32:19-27. Abstract

Das, SK; Miften, MM; Zhou, S; Bell, M; Munley, MT; Whiddon, CS; Craciunescu, O; Baydush, AH; Wong, T; Rosenman, JG; Dewhirst, MW; Marks, LB. Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions. Medical physics. 2004;31:1452-1461. Abstract

Craciunescu, OI; Das, SK; McCauley, RL; MacFall, JR; Samulski, TV. 3D numerical reconstruction of the hyperthermia induced temperature distribution in human sarcomas using DE-MRI measured tissue perfusion: validation against non-invasive MR temperature measurements. International Journal of Hyperthermia (Informa). 2001;17:221-239. Abstract

Craciunescu, OI; Das, SK; Poulson, JM; Samulski, TV. Three-dimensional tumor perfusion reconstruction using fractal interpolation functions. IEEE Transactions on Biomedical Engineering. 2001;48:462-473. Abstract

Craciunescu, OI; Clegg, ST. Pulsatile blood flow effects on temperature distribution and heat transfer in rigid vessels. Journal of Biomechanical Engineering. 2001;123:500-505. Abstract

Craciunescu, OI; Raaymakers, BW; Kotte, AN; Das, SK; Samulski, TV; Lagendijk, JJ. Discretizing large traceable vessels and using DE-MRI perfusion maps yields numerical temperature contours that match the MR noninvasive measurements. Medical physics. 2001;28:2289-2296. Abstract

Craciunescu, OI; Samulski, TV; MacFall, JR; Clegg, ST. Perturbations in hyperthermia temperature distributions associated with counter-current flow: numerical simulations and empirical verification. IEEE Transactions on Biomedical Engineering. 2000;47:435-443. Abstract

Craciunescu, OI; Howle, LE; Clegg, ST. Experimental evaluation of the thermal properties of two tissue equivalent phantom materials. International Journal of Hyperthermia (Informa). 1999;15:509-518. Abstract

Craciunescu, OI; Das, SK; Clegg, ST. Dynamic contrast-enhanced MRI and fractal characteristics of percolation clusters in two-dimensional tumor blood perfusion. Journal of Biomechanical Engineering. 1999;121:480-486. Abstract