Shiva Das, PhD

Adjunct Professor in the Department of Radiation Oncology
Department: Radiation Oncology
Division: Radiation Physics
Address: 04216 Hosp South
Durham, NC 27710
Office Phone: (919) 681-5424
Email: shiva.das@duke.edu

Research Interests

Intensity Modulated Radiotherapy optimization. Functional Image-guided radiotherapy (PET, SPECT). Modeling of Radiation-induced normal tissue complications (lung, cardiac) using neural nets, MART, self organizing maps, etc. Optimal selection of beam orientations for radiotherapy. Hyperthermia modeling.

Current Funded Grants:
NCI P01 CA042745-19: Hyperthermia and Perfusion Effects in Cancer Therapy,Project 2: Real Time Modeling and Control Using Finite Elements and MRI (Program Director).
NCI 1R01 CA115748-01A1: Accurate Prediction of Cardiac and Lung Radiation Injury (Principal Investigator).
Varian Medical Systems: Incorporation of Functional Image-guidance in Radiotherapy Planning (Principal Investigator).

Graduate School Teaching:
MP322: Advanced Photon Beam Radiation Therapy Planning (Fall Semester)

Postdoctoral Research Associates (Past and Current):
Alan Baydush, Ph.D.
Shifeng Chen, Ph.D.
Kung-Shan Cheng, Ph.D.
Sarah McGuire, Ph.D.
Vadim Stakhursky, Ph.D.

Publications

Yin, F-F; Das, S; Kirkpatrick, J; Oldham, M; Wang, Z; Zhou, S-M. Physics and imaging for targeting of oligometastases. Seminars in Radiation Oncology. 2006;16:85-101. Abstract

Das, SK; Macfall, J; McCauley, R; Craciunescu, O; Dewhirst, MW; Samulski, TV. Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data. International Journal of Hyperthermia (Informa). 2005;21:657-667. Abstract

Das, SK; Baydush, AH; Zhou, S; Miften, M; Yu, X; Craciunescu, O; Oldham, M; Light, K; Wong, T; Blazing, M; Borges-Neto, S; Dewhirst, MW; Marks, LB. Predicting radiotherapy-induced cardiac perfusion defects. Medical physics. 2005;32:19-27. Abstract

Baydush, AH; Marks, LB; Das, SK. Penalized likelihood fluence optimization with evolutionary components for intensity modulated radiation therapy treatment planning. Medical physics. 2004;31:2335-2343. Abstract

Zhou, S-M; Das, S; Wang, Z; Marks, LB. Relationship between the generalized equivalent uniform dose formulation and the Poisson statistics-based tumor control probability model. Medical physics. 2004;31:2606-2609. Abstract

Das, SK; Miften, MM; Zhou, S; Bell, M; Munley, MT; Whiddon, CS; Craciunescu, O; Baydush, AH; Wong, T; Rosenman, JG; Dewhirst, MW; Marks, LB. Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions. Medical physics. 2004;31:1452-1461. Abstract

Miften, MM; Das, SK; Su, M; Marks, LB. A dose-volume-based tool for evaluating and ranking IMRT treatment plans. Journal of applied clinical medical physics / American College of Medical Physics. 2004;5:1-14. Abstract

Miften, MM; Das, SK; Su, M; Marks, LB. Incorporation of functional imaging data in the evaluation of dose distributions using the generalized concept of equivalent uniform dose. Physics in Medicine and Biology. 2004;49:1711-1721. Abstract

Das, SK; Bell, M; Marks, LB; Rosenman, JG. A preliminary study of the role of modulated electron beams in intensity modulated radiotherapy, using automated beam orientation and modality selection. International Journal of Radiation Oncology, Biology, Physics. 2004;59:602-617. Abstract

Das, S; Cullip, T; Tracton, G; Chang, S; Marks, L; Anscher, M; Rosenman, J. Beam orientation selection for intensity-modulated radiation therapy based on target equivalent uniform dose maximization. International Journal of Radiation Oncology, Biology, Physics. 2003;55:215-224. Abstract

Miften, MM; Das, SK; Shafman, TD; Marks, LB. Optimization of a 90Sr/90Y radiation source train stepping for intravascular brachytherapy. Medical physics. 2002;29:2891-2896. Abstract

Kang, SK; Chou, RH; Dodge, RK; Clough, RW; Kang, HL; Bowen, MG; Steffey, BA; Das, SK; Zhou, SM; Whitehurst, AW; Buckley, NJ; Kim, JH; Joyner, RE; Sarmina, I; Montana, GS; Ingram, SS; Anscher, MS. Acute urinary toxicity following transperineal prostate brachytherapy using a modified Quimby loading method. International Journal of Radiation Oncology, Biology, Physics. 2001;50:937-945. Abstract

Craciunescu, OI; Das, SK; Poulson, JM; Samulski, TV. Three-dimensional tumor perfusion reconstruction using fractal interpolation functions. IEEE Transactions on Biomedical Engineering. 2001;48:462-473. Abstract

Craciunescu, OI; Raaymakers, BW; Kotte, AN; Das, SK; Samulski, TV; Lagendijk, JJ. Discretizing large traceable vessels and using DE-MRI perfusion maps yields numerical temperature contours that match the MR noninvasive measurements. Medical physics. 2001;28:2289-2296. Abstract

Das, SK; Jones, EA; Samulski, TV. A method of MRI-based thermal modelling for a RF phased array. International Journal of Hyperthermia (Informa). 2001;17:465-482. Abstract

Hernando, ML; Marks, LB; Bentel, GC; Zhou, SM; Hollis, D; Das, SK; Fan, M; Munley, MT; Shafman, TD; Anscher, MS; Lind, PA. Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer. International Journal of Radiation Oncology, Biology, Physics. 2001;51:650-659. Abstract

Craciunescu, OI; Das, SK; McCauley, RL; MacFall, JR; Samulski, TV. 3D numerical reconstruction of the hyperthermia induced temperature distribution in human sarcomas using DE-MRI measured tissue perfusion: validation against non-invasive MR temperature measurements. International Journal of Hyperthermia (Informa). 2001;17:221-239. Abstract

Das, SK; Clegg, ST; Samulski, TV. Electromagnetic thermal therapy power optimization for multiple source applicators. International Journal of Hyperthermia (Informa). 1999;15:291-308. Abstract

Craciunescu, OI; Das, SK; Clegg, ST. Dynamic contrast-enhanced MRI and fractal characteristics of percolation clusters in two-dimensional tumor blood perfusion. Journal of Biomechanical Engineering. 1999;121:480-486. Abstract

Das, SK; Clegg, ST; Samulski, TV. Computational techniques for fast hyperthermia temperature optimization. Medical physics. 1999;26:319-328. Abstract

Das, SK; Marks, LB. Selection of coplanar or noncoplanar beams using three-dimensional optimization based on maximum beam separation and minimized nontarget irradiation. International Journal of Radiation Oncology, Biology, Physics. 1997;38:643-655. Abstract

Clegg, ST; Das, SK; Fullar, E; Anderson, S; Blivin, J; Oleson, JR; Samulski, TV. Hyperthermia treatment planning and temperature distribution reconstruction: a case study. International Journal of Hyperthermia (Informa). 1996;12:65-76. Abstract

Das, SK; Clegg, ST; Anscher, MS; Samulski, TV. Simulation of electromagnetically induced hyperthermia: a finite element gridding method. International Journal of Hyperthermia (Informa). 1995;11:797-808. Abstract

Clegg, ST; Das, SK; Zhang, Y; Macfall, J; Fullar, E; Samulski, TV. Verification of a hyperthermia model method using MR thermometry. International Journal of Hyperthermia (Informa). 1995;11:409-424. Abstract