Mark Dewhirst, DVM, PhD

Professor of Radiation Oncology
Department: Radiation Oncology
Division: Radiation Onc-Cancer Biology
Address: 201 Med Sci Res Bldg
Research Drive
Durham, NC 27710
Office Phone: (919) 684-4180

Research Interests

Mark W. Dewhirst, DVM, PhD is the Gustavo S. Montana Professor of Radiation Oncology and Vice Director for Basic Science in the Duke Cancer Institute. Dr. Dewhirst has research interests in tumor hypoxia, angiogenesis, hyperthermia and drug transport. He has spent 30 years studying causes of tumor hypoxia and the use of hyperthermia to treat cancer. In collaboration with Professor David Needham in the Pratt School of Engineering, he has developed a novel thermally sensitive drug carrying liposome that has been successfully translated to human clinical trials. He has utilized the thermal characteristics of this liposome to develop an MR imageable form that can accurately reflect drug concentrations in tumors, which then is related to the extent of anti-tumor effect in pre-clinical models. This property has been widely used by other investigators, world-wide, particularly in the area of high intensity focused ultrasound, where it would be possible to literally paint drug to a target zone and visualize this process in real time, during heating. For his work in this area, Dr. Dewhirst was named a Fellow in the AAAS. Dr. Dewhirst has well over 500 peer-reviewed publications, book chapters and reviews, with >20,000 citations and an H-index of 73. He has given named lectures at the University of Western Ontario, Thomas Jefferson University and the New Zealand Cancer Society. He was awarded the Failla Medal and Lecture at the Radiation Research Society in 2008, the Eugene Robinson award for excellence hyperthermia research in 1992 and a similar award from the European Society for Hyperthermic Oncology in 2009. He was named a fellow of ASTRO in 2009 and was awarded the prestigious Gold Medal from the same society in 2012. He is a Senior Editor of Cancer Research and Editor-in-Chief of the International Journal of Hyperthermia. He has mentored 24 graduate students, and many postdoctoral fellows, residents, junior faculty and medical students. He has been particularly skillful in assisting those he has mentored to obtain DOD and NIH fellowships, K awards and first R01 grants. His skill in mentoring has been recognized by the Duke Comprehensive Cancer Center, the Medical Physics Graduate Training programs and the School of Medicine, where he has received “Mentor of the Year” awards. In 2011 he was selected to become the first Associate Dean of Faculty Mentoring in the Duke School of Medicine. In this position, he is implementing a comprehensive program to enhance success in obtaining NIH funding. He graduated from the University of Arizona in 1971 with a degree in Chemistry and Colorado State University in 1975 and 1979 with DVM and PhD degrees, respectively.


Hanna, G; Fontanella, A; Palmer, G; Shan, S; Radiloff, DR; Zhao, Y; Irwin, D; Hamilton, K; Boico, A; Piantadosi, CA; Blueschke, G; Dewhirst, M; McMahon, T; Schroeder, T. Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy. American journal of physiology. Lung cellular and molecular physiology. 2013;304:L86-L91. Abstract

Zhong, J; Rajaram, N; Brizel, DM; Frees, AE; Ramanujam, N; Batinic-Haberle, I; Dewhirst, MW. Radiation induces aerobic glycolysis through reactive oxygen species. Radiotherapy and Oncology. 2013;106:390-396. Abstract

Jones, LW; Viglianti, BL; Tashjian, JA; Kothadia, SM; Keir, ST; Freedland, SJ; Potter, MQ; Moon, EJ; Schroeder, T; Herndon, JE; Dewhirst, MW. Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. Journal of applied physiology (Bethesda, Md. : 1985). 2010;108:343-348. Abstract

Kennedy, KM; Dewhirst, MW. Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future oncology (London, England). 2010;6:127-148. Abstract

Palmer, GM; Boruta, RJ; Viglianti, BL; Lan, L; Spasojevic, I; Dewhirst, MW. Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy. Journal of Controlled Release. 2010;142:457-464. Abstract

Skala, MC; Fontanella, A; Hendargo, H; Dewhirst, MW; Izatt, JA. Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. Optics Letters. 2009;34:289-291. Abstract

Vishwanath, K; Klein, D; Chang, K; Schroeder, T; Dewhirst, MW; Ramanujam, N. Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts. Journal of Biomedical Optics. 2009;14:054051. Abstract

Dewhirst, MW. Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiation Research. 2009;172:653-665. Abstract

Hardee, ME; Dewhirst, MW; Agarwal, N; Sorg, BS. Novel imaging provides new insights into mechanisms of oxygen transport in tumors. Current molecular medicine. 2009;9:435-441. Abstract

Pries, AR; Cornelissen, AJM; Sloot, AA; Hinkeldey, M; Dreher, MR; Höpfner, M; Dewhirst, MW; Secomb, TW. Structural adaptation and heterogeneity of normal and tumor microvascular networks. PLoS computational biology. 2009;5:e1000394. Abstract

Viglianti, BL; Lora-Michiels, M; Poulson, JM; Lan, L; Yu, D; Sanders, L; Craciunescu, O; Vujaskovic, Z; Thrall, DE; Macfall, J; Charles, CH; Wong, T; Dewhirst, MW. Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009;15:4993-5001. Abstract

Zhang, G; Palmer, GM; Dewhirst, MW; Fraser, CL. A dual-emissive-materials design concept enables tumour hypoxia imaging. Nature Materials. 2009;8:747-751. Abstract

Palmer, GM; Viola, RJ; Schroeder, T; Yarmolenko, PS; Dewhirst, MW; Ramanujam, N. Quantitative diffuse reflectance and fluorescence spectroscopy: tool to monitor tumor physiology in vivo. Journal of Biomedical Optics. 2009;14:024010. Abstract

Craciunescu, OI; Blackwell, KL; Jones, EL; Macfall, JR; Yu, D; Vujaskovic, Z; Wong, TZ; Liotcheva, V; Rosen, EL; Prosnitz, LR; Samulski, TV; Dewhirst, MW. DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study. International Journal of Hyperthermia (Informa). 2009;25:405-415. Abstract

Craciunescu, OI; Stauffer, PR; Soher, BJ; Wyatt, CR; Arabe, O; Maccarini, P; Das, SK; Cheng, K-S; Wong, TZ; Jones, EL; Dewhirst, MW; Vujaskovic, Z; MacFall, JR. Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. Medical physics. 2009;36:4848-4858. Abstract

Cárdenas-Navia, LI; Mace, D; Richardson, RA; Wilson, DF; Shan, S; Dewhirst, MW. The pervasive presence of fluctuating oxygenation in tumors. Cancer Research. 2008;68:5812-5819. Abstract

Manzoor, AA; Schroeder, T; Dewhirst, MW. One-stop-shop tumor imaging: buy hypoxia, get lactate free. Journal of Clinical Investigation. 2008;118:1616-1619. Abstract

Viola, RJ; Provenzale, JM; Li, F; Li, C-Y; Yuan, H; Tashjian, J; Dewhirst, MW. In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy. AJR. American journal of roentgenology. 2008;191:1779-1784. Abstract

Sorg, BS; Hardee, ME; Agarwal, N; Moeller, BJ; Dewhirst, MW. Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. Journal of Biomedical Optics. 2008;13:014026. Abstract

Dewhirst, MW; Cao, Y; Moeller, B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nature Reviews Cancer. 2008;8:425-437. Abstract

Sonveaux, P; Végran, F; Schroeder, T; Wergin, MC; Verrax, J; Rabbani, ZN; De Saedeleer, CJ; Kennedy, KM; Diepart, C; Jordan, BF; Kelley, MJ; Gallez, B; Wahl, ML; Feron, O; Dewhirst, MW. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. Journal of Clinical Investigation. 2008;118:3930-3942. Abstract

Vlahovic, G; Ponce, AM; Rabbani, Z; Salahuddin, FK; Zgonjanin, L; Spasojevic, I; Vujaskovic, Z; Dewhirst, MW. Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts. British Journal of Cancer. 2007;97:735-740. Abstract

Dewhirst, MW; Navia, IC; Brizel, DM; Willett, C; Secomb, TW. Multiple etiologies of tumor hypoxia require multifaceted solutions. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007;13:375-377. Abstract

Dewhirst, MW. Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Research. 2007;67:854-855. Abstract

Hardee, ME; Cao, Y; Fu, P; Jiang, X; Zhao, Y; Rabbani, ZN; Vujaskovic, Z; Dewhirst, MW; Arcasoy, MO. Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. PloS one. 2007;2:e549. Abstract

Cao, Y; Sonveaux, P; Liu, S; Zhao, Y; Mi, J; Clary, BM; Li, C-Y; Kontos, CD; Dewhirst, MW. Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. Cancer Research. 2007;67:3835-3844. Abstract

Ponce, AM; Viglianti, BL; Yu, D; Yarmolenko, PS; Michelich, CR; Woo, J; Bally, MB; Dewhirst, MW. Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects. Journal of the National Cancer Institute. 2007;99:53-63. Abstract

Li, F; Sonveaux, P; Rabbani, ZN; Liu, S; Yan, B; Huang, Q; Vujaskovic, Z; Dewhirst, MW; Li, C-Y. Regulation of HIF-1alpha stability through S-nitrosylation. Molecular Cell. 2007;26:63-74. Abstract

Dreher, MR; Liu, W; Michelich, CR; Dewhirst, MW; Chilkoti, A. Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors. Cancer Research. 2007;67:4418-4424. Abstract

Lora-Michiels, M; Yu, D; Sanders, L; Poulson, JM; Azuma, C; Case, B; Vujaskovic, Z; Thrall, DE; Charles, HC; Dewhirst, MW. Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006;12:5733-5740. Abstract

Dreher, MR; Liu, W; Michelich, CR; Dewhirst, MW; Yuan, F; Chilkoti, A. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. Journal of the National Cancer Institute. 2006;98:335-344. Abstract

Lanzen, J; Braun, RD; Klitzman, B; Brizel, D; Secomb, TW; Dewhirst, MW. Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Research. 2006;66:2219-2223. Abstract

Dressman, HK; Hans, C; Bild, A; Olson, JA; Rosen, E; Marcom, PK; Liotcheva, VB; Jones, EL; Vujaskovic, Z; Marks, J; Dewhirst, MW; West, M; Nevins, JR; Blackwell, K. Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006;12:819-826. Abstract

Hauck, ML; LaRue, SM; Petros, WP; Poulson, JM; Yu, D; Spasojevic, I; Pruitt, AF; Klein, A; Case, B; Thrall, DE; Needham, D; Dewhirst, MW. Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006;12:4004-4010. Abstract

Hicks, KO; Pruijn, FB; Secomb, TW; Hay, MP; Hsu, R; Brown, JM; Denny, WA; Dewhirst, MW; Wilson, WR. Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs. Journal of the National Cancer Institute. 2006;98:1118-1128. Abstract

Yuan, H; Schroeder, T; Bowsher, JE; Hedlund, LW; Wong, T; Dewhirst, MW. Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2006;47:989-998. Abstract

Thrall, DE; Larue, SM; Pruitt, AF; Case, B; Dewhirst, MW. Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas. International Journal of Hyperthermia (Informa). 2006;22:365-373. Abstract

Das, SK; Macfall, J; McCauley, R; Craciunescu, O; Dewhirst, MW; Samulski, TV. Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data. International Journal of Hyperthermia (Informa). 2005;21:657-667. Abstract

Moeller, BJ; Dreher, MR; Rabbani, ZN; Schroeder, T; Cao, Y; Li, CY; Dewhirst, MW. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell. 2005;8:99-110. Abstract

Cao, Y; Li, C-Y; Moeller, BJ; Yu, D; Zhao, Y; Dreher, MR; Shan, S; Dewhirst, MW. Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. Cancer Research. 2005;65:5498-5505. Abstract

Dewhirst, MW; Poulson, JM; Yu, D; Sanders, L; Lora-Michiels, M; Vujaskovic, Z; Jones, EL; Samulski, TV; Powers, BE; Brizel, DM; Prosnitz, LR; Charles, HC. Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy. International Journal of Radiation Oncology, Biology, Physics. 2005;61:480-491. Abstract

Sorg, BS; Moeller, BJ; Donovan, O; Cao, Y; Dewhirst, MW. Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. Journal of Biomedical Optics. 2005;10:44004. Abstract

Thrall, DE; LaRue, SM; Yu, D; Samulski, T; Sanders, L; Case, B; Rosner, G; Azuma, C; Poulson, J; Pruitt, AF; Stanley, W; Hauck, ML; Williams, L; Hess, P; Dewhirst, MW. Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005;11:5206-5214. Abstract

Jones, EL; Oleson, JR; Prosnitz, LR; Samulski, TV; Vujaskovic, Z; Yu, D; Sanders, LL; Dewhirst, MW. Randomized trial of hyperthermia and radiation for superficial tumors. Journal of Clinical Oncology. 2005;23:3079-3085. Abstract

Richardson, RA; Dewhirst, MW. The effect of nicotinamide & hyperoxic gases on blood glucose. Advances in experimental medicine and biology. 2003;510:375-378. Abstract

Dewhirst, MW. Mechanisms underlying hypoxia development in tumors. Advances in experimental medicine and biology. 2003;510:51-56. Abstract

Lockhart, AC; Braun, RD; Yu, D; Ross, JR; Dewhirst, MW; Humphrey, JS; Thompson, S; Williams, KM; Klitzman, B; Yuan, F; Grichnik, JM; Proia, AD; Conway, DA; Hurwitz, HI. Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003;9:586-593. Abstract

Zeman, EM; Dynlacht, JR; Rosenstein, BS; Dewhirst, MW; ASTRO Joint Working Group on Radiobiology Teaching. Toward a national consensus: teaching radiobiology to radiation oncology residents. International Journal of Radiation Oncology, Biology, Physics. 2002;54:861-872. Abstract

Haroon, ZA; Amin, K; Saito, W; Wilson, W; Greenberg, CS; Dewhirst, MW. SU5416 delays wound healing through inhibition of TGF-beta 1 activation. Cancer Biology and Therapy. 2002;1:121-126. Abstract

Wong, CW; Song, C; Grimes, MM; Fu, W; Dewhirst, MW; Muschel, RJ; Al-Mehdi, A-B. Intravascular location of breast cancer cells after spontaneous metastasis to the lung. The American journal of pathology. 2002;161:749-753. Abstract

Dynlacht, JR; Dewhirst, MW; Hall, EJ; Rosenstein, BS; Zeman, EM. Toward a consensus on radiobiology teaching to radiation oncology residents. Radiation Research. 2002;157:599-606. Abstract

Hale, LP; Braun, RD; Gwinn, WM; Greer, PK; Dewhirst, MW. Hypoxia in the thymus: role of oxygen tension in thymocyte survival. American journal of physiology. Heart and circulatory physiology. 2002;282:H1467-H1477. Abstract

Vujaskovic, Z; Batinic-Haberle, I; Rabbani, ZN; Feng, Q-F; Kang, SK; Spasojevic, I; Samulski, TV; Fridovich, I; Dewhirst, MW; Anscher, MS. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radical Biology & Medicine. 2002;33:857-863. Abstract

Kavanagh, BD; Secomb, TW; Hsu, R; Lin, PS; Venitz, J; Dewhirst, MW. A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation. International Journal of Radiation Oncology, Biology, Physics. 2002;53:172-179. Abstract

Braun, RD; Lanzen, JL; Turnage, JA; Rosner, G; Dewhirst, MW. Effects of the interaction between carbogen and nicotinamide on R3230 Ac tumor blood flow in Fischer 344 rats. Radiation Research. 2001;155:724-733. Abstract

Snyder, SA; Lanzen, JL; Braun, RD; Rosner, G; Secomb, TW; Biaglow, J; Brizel, DM; Dewhirst, MW. Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. International Journal of Radiation Oncology, Biology, Physics. 2001;51:494-506. Abstract

Ettinger, SN; Poellmann, CC; Wisniewski, NA; Gaskin, AA; Shoemaker, JS; Poulson, JM; Dewhirst, MW; Klitzman, B. Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. Cancer Research. 2001;61:7964-7970. Abstract

Needham, D; Dewhirst, MW. The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Advanced Drug Delivery Reviews. 2001;53:285-305. Abstract

Tozer, GM; Prise, VE; Wilson, J; Cemazar, M; Shan, S; Dewhirst, MW; Barber, PR; Vojnovic, B; Chaplin, DJ. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Research. 2001;61:6413-6422. Abstract

Brizel, DM; Schroeder, T; Scher, RL; Walenta, S; Clough, RW; Dewhirst, MW; Mueller-Klieser, W. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics. 2001;51:349-353. Abstract

Maguire, PD; Samulski, TV; Prosnitz, LR; Jones, EL; Rosner, GL; Powers, B; Layfield, LW; Brizel, DM; Scully, SP; Harrelson, JM; Dewhirst, MW. A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy. International Journal of Hyperthermia (Informa). 2001;17:283-290. Abstract

Neeman, M; Provenzale, JM; Dewhirst, MW. Magnetic resonance imaging applications in the evaluation of tumor angiogenesis. Seminars in Radiation Oncology. 2001;11:70-82. Abstract

Vujaskovic, Z; Anscher, MS; Feng, QF; Rabbani, ZN; Amin, K; Samulski, TS; Dewhirst, MW; Haroon, ZA. Radiation-induced hypoxia may perpetuate late normal tissue injury. International Journal of Radiation Oncology, Biology, Physics. 2001;50:851-855. Abstract

Lohr, F; Lo, DY; Zaharoff, DA; Hu, K; Zhang, X; Li, Y; Zhao, Y; Dewhirst, MW; Yuan, F; Li, CY. Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. Cancer Research. 2001;61:3281-3284. Abstract

Pogue, BW; Braun, RD; Lanzen, JL; Erickson, C; Dewhirst, MW. Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin. Photochemistry & Photobiology. 2001;74:700-706. Abstract

Meyer, DE; Shin, BC; Kong, GA; Dewhirst, MW; Chilkoti, A. Drug targeting using thermally responsive polymers and local hyperthermia. Journal of Controlled Release. 2001;74:213-224. Abstract

Kong, G; Braun, RD; Dewhirst, MW. Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. Cancer Research. 2001;61:3027-3032. Abstract

Neeman, M; Dafni, H; Bukhari, O; Braun, RD; Dewhirst, MW. In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation: validation by intravital microscopy. Magnetic Resonance in Medicine. 2001;45:887-898. Abstract

Shan, S; Lockhart, AC; Saito, WY; Knapp, AM; Laderoute, KR; Dewhirst, MW. The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001;7:2590-2596. Abstract

Braun, RD; Lanzen, JL; Snyder, SA; Dewhirst, MW. Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. American journal of physiology. Heart and circulatory physiology. 2001;280:H2533-H2544. Abstract

Lohr, F; Huang, Q; Hu, K; Dewhirst, MW; Li, CY. Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001;7:3625-3628. Abstract

Meyer, DE; Kong, GA; Dewhirst, MW; Zalutsky, MR; Chilkoti, A. Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia. Cancer Research. 2001;61:1548-1554. Abstract

Walenta, S; Snyder, S; Haroon, ZA; Braun, RD; Amin, K; Brizel, D; Mueller-Klieser, W; Chance, B; Dewhirst, MW. Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. International Journal of Radiation Oncology, Biology, Physics. 2001;51:840-848. Abstract

Connor, CE; Norris, JD; Broadwater, G; Willson, TM; Gottardis, MM; Dewhirst, MW; McDonnell, DP. Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. Cancer Research. 2001;61:2917-2922. Abstract

Lal, A; Peters, H; St Croix, B; Haroon, ZA; Dewhirst, MW; Strausberg, RL; Kaanders, JH; van der Kogel, AJ; Riggins, GJ. Transcriptional response to hypoxia in human tumors. Journal of the National Cancer Institute. 2001;93:1337-1343. Abstract

Li, CY; Little, JB; Hu, K; Zhang, W; Zhang, L; Dewhirst, MW; Huang, Q. Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. Cancer Research. 2001;61:428-432. Abstract

Brizel, DM; Scully, SP; Harrelson, JM; Layfield, LJ; Bean, JM; Prosnitz, LR; Dewhirst, MW. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Research. 1996;56:941-943. Abstract

Dewhirst, MW; Kimura, H; Rehmus, SW; Braun, RD; Papahadjopoulos, D; Hong, K; Secomb, TW. Microvascular studies on the origins of perfusion-limited hypoxia. The British journal of cancer. Supplement. 1996;27:S247-S251. Abstract

Kimura, H; Wu, NZ; Dodge, R; Spencer, DP; Klitzman, BM; McIntyre, TM; Dewhirst, MW. Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. International Journal of Radiation Oncology, Biology, Physics. 1995;33:627-633. Abstract

Sostman, HD; Prescott, DM; Dewhirst, MW; Dodge, RK; Thrall, DE; Page, RL; Tucker, JA; Harrelson, JM; Reece, G; Leopold, KA. MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas. Radiology. 1994;190:269-275. Abstract