Nan-Kuei Chen, PhD

Adjunct Associate Professor in the Department of Radiology
Department: Radiology
Address: 40 Duke Medicine Circle
Davison 414, Box 3918
Durham, NC 27710
Office Phone: (919) 613-6207

Research Interests

Dr. Chen is a magnetic resonance imaging (MRI) physicist with research interest in fast image acquisition methodology, pulse sequence design, MRI artifact correction, and application of MRI to studies of neurological diseases. He has been developing novel high-resolution imaging protocols and analysis procedures for mapping structural and functional connectivity of brains. More generally, Dr. Chen's research involves the application of MRI in translational contexts. He has been serving as the principal investigator on NIH-funded R01, R21 and R03 grants, and has had extensive experience as a co-investigator on NIH-funded projects.


Guhaniyogi, S; Chu, M-L; Chang, H-C; Song, AW; Chen, N-K. Motion immune diffusion imaging using augmented MUSE for high-resolution multi-shot EPI. Magnetic Resonance in Medicine. 2016;75:639-652. Abstract

Chang, H-C; Chen, N-K. Joint correction of Nyquist artifact and minuscule motion-induced aliasing artifact in interleaved diffusion weighted EPI data using a composite two-dimensional phase correction procedure. Magnetic Resonance Imaging. 2016;34:974-979.

Chang, H-C; Guhaniyogi, S; Chen, N-K. Interleaved diffusion-weighted improved by adaptive partial-Fourier and multiband multiplexed sensitivity-encoding reconstruction. Magnetic Resonance in Medicine. 2015;73:1872-1884.

Chou, Y-H; You, H; Wang, H; Zhao, Y-P; Hou, B; Chen, N-K; Feng, F. Effect of Repetitive Transcranial Magnetic Stimulation on fMRI Resting-State Connectivity in Multiple System Atrophy. Brain Connectivity. 2015;5:451-459. Abstract

Truong, T-K; Song, AW; Chen, N-K. Correction for Eddy Current-Induced Echo-Shifting Effect in Partial-Fourier Diffusion Tensor Imaging. BioMed Research International. 2015;2015:185026. Abstract

Chang, H-C; Guhaniyogi, S; Chen, N-K. Interleaved diffusion-weighted improved by adaptive partial-Fourier and multiband multiplexed sensitivity-encoding reconstruction. Magnetic Resonance in Medicine. 2015;73:1872-1884.

Chang, H-C; Sundman, M; Petit, L; Guhaniyogi, S; Chu, M-L; Petty, C; Song, AW; Chen, N-K. Human brain diffusion tensor imaging at submillimeter isotropic resolution on a 3Tesla clinical MRI scanner. NeuroImage. 2015;118:667-675. Abstract

Wu, M-L; Chang, H-C; Chao, T-C; Chen, N-K. Efficient imaging of midbrain nuclei using inverse double-echo steady-state acquisition. Medical physics. 2015;42:4367-4374. Abstract

Chou, Y-H; Hickey, PT; Sundman, M; Song, AW; Chen, N-K. Effects of repetitive transcranial magnetic stimulation on motor symptoms in Parkinson disease: a systematic review and meta-analysis. JAMA Neurology. 2015;72:432-440. Abstract

Chu, M-L; Chang, H-C; Chung, H-W; Truong, T-K; Bashir, MR; Chen, N-K. POCS-based reconstruction of multiplexed sensitivity encoded MRI (POCSMUSE): A general algorithm for reducing motion-related artifacts. Magnetic Resonance in Medicine. 2015;74:1336-1348. Abstract

Weingarten, CP; Sundman, MH; Hickey, P; Chen, N-K. Neuroimaging of Parkinson's disease: Expanding views. Neuroscience & Biobehavioral Reviews. 2015;59:16-52.

Song, AW; Chang, H-C; Petty, C; Guidon, A; Chen, N-K. Improved delineation of short cortical association fibers and gray/white matter boundary using whole-brain three-dimensional diffusion tensor imaging at submillimeter spatial resolution. Brain Connectivity. 2014;4:636-640. Abstract

Yang, YH; Huang, TY; Wang, FN; Chuang, TC; Chen, NK. Accelerating EPI Distortion Correction by Utilizing a Modern GPU-Based Parallel Computation. Journal of Neuroimaging. 2013;23:202-206.

Chen, N-K; Guidon, A; Chang, H-C; Song, AW. A robust multi-shot scan strategy for high-resolution diffusion weighted MRI enabled by multiplexed sensitivity-encoding (MUSE). NeuroImage. 2013;72:41-47. Abstract

Truong, T-K; Chen, N-K; Song, AW. Inherent correction of motion-induced phase errors in multishot spiral diffusion-weighted imaging. Magnetic Resonance in Medicine. 2012;68:1255-1261. Abstract

Madden, DJ; Bennett, IJ; Burzynska, A; Potter, GG; Chen, N-K; Song, AW. Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 2012;1822:386-400. Abstract

Chou, Y-H; Panych, LP; Dickey, CC; Petrella, JR; Chen, N-K. Investigation of long-term reproducibility of intrinsic connectivity network mapping: a resting-state fMRI study. American Journal of Neuroradiology. 2012;33:833-838. Abstract

Rosas, HD; Chen, YI; Doros, G; Salat, DH; Chen, N-K; Kwong, KK; Bush, A; Fox, J; Hersch, SM. Alterations in brain transition metals in Huntington disease: an evolving and intricate story. Archives of Neurology. 2012;69:887-893. Abstract

Truong, T-K; Chen, N-K; Song, AW. Dynamic correction of artifacts due to susceptibility effects and time-varying eddy currents in diffusion tensor imaging. NeuroImage. 2011;57:1343-1347. Abstract

Chen, N-K; Avram, AV; Song, AW. Two-dimensional phase cycled reconstruction for inherent correction of echo-planar imaging Nyquist artifacts. Magnetic Resonance in Medicine. 2011;66:1057-1066. Abstract

Truong, T-K; Chen, N-K; Song, AW. Application of k-space energy spectrum analysis for inherent and dynamic B0 mapping and deblurring in spiral imaging. Magnetic Resonance in Medicine. 2010;64:1121-1127. Abstract

Young, GS; Feng, F; Shen, H; Chen, N-K. Susceptibility-enhanced 3-Tesla T1-weighted spoiled gradient echo of the midbrain nuclei for guidance of deep brain stimulation implantation. Neurosurgery. 2009;65:809-815. Abstract

Lin, J-M; Tsai, S-Y; Liu, H-S; Chung, H-W; Mulkern, RV; Cheng, C-M; Yeh, T-C; Chen, N-K. Quantification of non-water-suppressed MR spectra with correction for motion-induced signal reduction. Magnetic Resonance in Medicine. 2009;62:1394-1403. Abstract

Chen, N-K; Chou, Y-H; Song, AW; Madden, DJ. Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity. Brain Structure and Function. 2009;213:571-585. Abstract

Chen, N-K; Oshio, K; Panych, LP. Improved image reconstruction for partial Fourier gradient-echo echo-planar imaging (EPI). Magnetic Resonance in Medicine. 2008;59:916-924. Abstract

McDannold, N; Barnes, AS; Rybicki, FJ; Oshio, K; Chen, N-K; Hynynen, K; Mulkern, RV. Temperature mapping considerations in the breast with line scan echo planar spectroscopic imaging. Magnetic Resonance in Medicine. 2007;58:1117-1123. Abstract

Chen, N-K; Oshio, K; Panych, LP. Application of k-space energy spectrum analysis to susceptibility field mapping and distortion correction in gradient-echo EPI. NeuroImage. 2006;31:609-622. Abstract

Brass, SD; Chen, N-K; Mulkern, RV; Bakshi, R. Magnetic resonance imaging of iron deposition in neurological disorders. Topics in Magnetic Resonance Imaging. 2006;17:31-40. Abstract

Lin, F-H; Huang, T-Y; Chen, N-K; Wang, F-N; Stufflebeam, SM; Belliveau, JW; Wald, LL; Kwong, KK. Functional MRI using regularized parallel imaging acquisition. Magnetic Resonance in Medicine. 2005;54:343-353. Abstract

Wang, F-N; Huang, T-Y; Lin, F-H; Chuang, T-C; Chen, N-K; Chung, H-W; Chen, C-Y; Kwong, KK. PROPELLER EPI: an MRI technique suitable for diffusion tensor imaging at high field strength with reduced geometric distortions. Magnetic Resonance in Medicine. 2005;54:1232-1240. Abstract

Chen, N-K; Wyrwicz, AM. Removal of EPI Nyquist ghost artifacts with two-dimensional phase correction. Magnetic Resonance in Medicine. 2004;51:1247-1253. Abstract

Chen, N-K; Oshio, K; Panych, LP; Rybicki, FJ; Mulkern, RV. Spatially selective T2 and T2 * measurement with line-scan echo-planar spectroscopic imaging. Journal of Magnetic Resonance. 2004;171:90-96. Abstract

Chen, N-K; Egorova, S; Guttmann, CRG; Panych, LP. Functional MRI with variable echo time acquisition. NeuroImage. 2003;20:2062-2070. Abstract

Chen, N-K; Dickey, CC; Yoo, S-S; Guttmann, CRG; Panych, LP. Selection of voxel size and slice orientation for fMRI in the presence of susceptibility field gradients: application to imaging of the amygdala. NeuroImage. 2003;19:817-825. Abstract

Miller, MJ; Chen, N-K; Li, L; Tom, B; Weiss, C; Disterhoft, JF; Wyrwicz, AM. fMRI of the conscious rabbit during unilateral classical eyeblink conditioning reveals bilateral cerebellar activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003;23:11753-11758. Abstract

Chen, NK; Wyrwicz, AM. Optimized distortion correction technique for echo planar imaging. Magnetic Resonance in Medicine. 2001;45:525-528. Abstract

Wyrwicz, AM; Chen, N; Li, L; Weiss, C; Disterhoft, JF. fMRI of visual system activation in the conscious rabbit. Magnetic Resonance in Medicine. 2000;44:474-478. Abstract

Chen, NK; Wyrwicz, AM. Correction for EPI distortions using multi-echo gradient-echo imaging. Magnetic Resonance in Medicine. 1999;41:1206-1213. Abstract

Chen, NK; Wyrwicz, AM. Removal of intravoxel dephasing artifact in gradient-echo images using a field-map based RF refocusing technique. Magnetic Resonance in Medicine. 1999;42:807-812. Abstract