John P Kirkpatrick, MD, PhD

Associate Professor of Radiation Oncology
Department: Radiation Oncology
Division: Radiation Onc-Clinical Sup
Address: Radiation Oncology
Durham, NC 27710
Office Phone: (919) 668-7342

Research Interests

Malignant and benign tumors of the brain, spine and base of skull. Mathematical modelling of tumor metabolism, mass transfer and the response to ionizing radiation. Enhancing clinical outcome in stereotactic radiosurgery, fractionated stereotactic radiotherapy and stereotactic body radiotherapy.


Sperduto, PW; Chao, ST; Sneed, PK; Luo, X; Suh, J; Roberge, D; Bhatt, A; Jensen, AW; Brown, PD; Shih, H; Kirkpatrick, J; Schwer, A; Gaspar, LE; Fiveash, JB; Chiang, V; Knisely, J; Sperduto, CM; Mehta, M. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. International Journal of Radiation: Oncology - Biology - Physics. 2010;77:655-661. Abstract

Chang, Z; Wang, Z; Ma, J; O'Daniel, JC; Kirkpatrick, J; Yin, F-F. 6D image guidance for spinal non-invasive stereotactic body radiation therapy: Comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT. Radiotherapy and Oncology. 2010;95:116-121. Abstract

Kelsey, CR; Mukundan, S; Wang, Z; Hahn, CA; Soher, BJ; Kirkpatrick, JP. Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy. Neuro-Oncology. 2010;12:145-152. Abstract

Mayo, C; Martel, MK; Marks, LB; Flickinger, J; Nam, J; Kirkpatrick, J. Radiation dose-volume effects of optic nerves and chiasm. International Journal of Radiation: Oncology - Biology - Physics. 2010;76:S28-S35. Abstract

Kirkpatrick, JP; van der Kogel, AJ; Schultheiss, TE. Radiation dose-volume effects in the spinal cord. International Journal of Radiation: Oncology - Biology - Physics. 2010;76:S42-S49. Abstract

Kirkpatrick, JP; Brenner, DJ; Orton, CG. Point/Counterpoint. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Medical physics. 2009;36:3381-3384. Abstract

Wang, Z; Nelson, JW; Yoo, S; Wu, QJ; Kirkpatrick, JP; Marks, LB; Yin, F-F. Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:571-577. Abstract

Nelson, JW; Yoo, DS; Sampson, JH; Isaacs, RE; Larrier, NA; Marks, LB; Yin, F-F; Wu, QJ; Wang, Z; Kirkpatrick, JP. Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:1369-1375. Abstract

Wu, QJ; Wang, Z; Kirkpatrick, JP; Chang, Z; Meyer, JJ; Lu, M; Huntzinger, C; Yin, F-F. Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions. Radiation Oncology. 2009;4:3. Abstract

Hahn, CA; Zhou, S-M; Raynor, R; Tisch, A; Light, K; Shafman, T; Wong, T; Kirkpatrick, J; Turkington, T; Hollis, D; Marks, LB. Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:1082-1087. Abstract

Kirkpatrick, JP; Rabbani, ZN; Bentley, RC; Hardee, ME; Karol, S; Meyer, J; Oosterwijk, E; Havrilesky, L; Secord, AA; Vujaskovic, Z; Dewhirst, MW; Jones, EL. Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer. Biomarker Insights. 2008;3:45-55. Abstract

Kirkpatrick, JP; Meyer, JJ; Marks, LB. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Seminars in Radiation Oncology. 2008;18:240-243. Abstract

Kirkpatrick, JP; Dewhirst, MW. Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder. Radiation Research. 2008;169:350-354. Abstract

Kasibhatla, M; Kirkpatrick, JP; Brizel, DM. How much radiation is the chemotherapy worth in advanced head and neck cancer?. International Journal of Radiation Oncology, Biology, Physics. 2007;68:1491-1495. Abstract

Soper, JT; Spillman, M; Sampson, JH; Kirkpatrick, JP; Wolf, JK; Clarke-Pearson, DL. High-risk gestational trophoblastic neoplasia with brain metastases: individualized multidisciplinary therapy in the management of four patients. Gynecologic Oncology. 2007;104:691-694. Abstract

Koontz, BF; Kirkpatrick, JP; Clough, RW; Prosnitz, RG; Gockerman, JP; Moore, JO; Prosnitz, LR. Combined-modality therapy versus radiotherapy alone for treatment of early-stage Hodgkin's disease: cure balanced against complications. Journal of Clinical Oncology. 2006;24:605-611. Abstract

Kirkpatrick, JP. Tumor hypoxia and prognosis in human gliomas. Cancer Journal. 2006;12:451-454. Abstract

Meyer, JJ; Marks, LB; Halperin, EC; Kirkpatrick, JP. Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. Radiation Oncology. 2006;1:48. Abstract

Kirkpatrick, JP; Hardee, ME; Snyder, SA; Peltz, CM; Zhao, Y; Brizel, DM; Dewhirst, MW; Blackwell, KL. The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma. Radiation Research. 2006;165:192-201. Abstract

Hardee, ME; Arcasoy, MO; Blackwell, KL; Kirkpatrick, JP; Dewhirst, MW. Erythropoietin biology in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006;12:332-339. Abstract

Yin, F-F; Das, S; Kirkpatrick, J; Oldham, M; Wang, Z; Zhou, S-M. Physics and imaging for targeting of oligometastases. Seminars in Radiation Oncology. 2006;16:85-101. Abstract

Hardee, ME; Kirkpatrick, JP; Shan, S; Snyder, SA; Vujaskovic, Z; Rabbani, ZN; Dewhirst, MW; Blackwell, KL. Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. British Journal of Cancer. 2005;93:1350-1355. Abstract

Kirkpatrick, JP; Anscher, MS. Radiotherapy for locally recurrent prostate cancer. Clinical advances in hematology & oncology : H&O. 2005;3:933-942. Abstract

Kirkpatrick, JP; Marks, LB. Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data. International Journal of Radiation Oncology, Biology, Physics. 2004;58:641-654. Abstract

Kirkpatrick, JP; Cárdenas-Navia, LI; Dewhirst, MW. Predicting the effect of temporal variations in PO2 on tumor radiosensitivity. International Journal of Radiation Oncology, Biology, Physics. 2004;59:822-833. Abstract

Blackwell, KL; Kirkpatrick, JP; Snyder, SA; Broadwater, G; Farrell, F; Jolliffe, L; Brizel, DM; Dewhirst, MW. Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin. Cancer Research. 2003;63:6162-6165. Abstract

Kirkpatrick, JP; Brizel, DM; Dewhirst, MW. A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. Radiation Research. 2003;159:336-344. Abstract

Kang, SK; Kirkpatrick, JP; Halperin, EC. Low-dose radiation for posttransplant lymphoproliferative disorder. American Journal of Clinical Oncology: Cancer Clinical Trials. 2003;26:210-214. Abstract

Kirkpatrick, JP; McIntire, LV; Moake, JL; Cimo, PL. Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents. Thrombosis and haemostasis. 1980;42:1483-1489. Abstract

Kirkpatrick, JP; McIntire, LV; Moake, JL; Peterson, DM. Metabolic requirements of contractile force generation in platelet rich plasma - a rheological study. Biorheology. 1980;17:411-418. Abstract

Kirkpatrick, JP; McIntire, LV; Moake, JL. Streptokinase-induced degradation of crosslinked and uncrosslinked clots. Thrombosis Research. 1978;13:569-575. Abstract