Mark Oldham, PhD

Professor of Radiation Oncology
Department: Radiation Oncology
Division: Radiation Physics
Address: 04214 Duke South Red Zone
Duke South Clinics
Durham, NC 27710
Office Phone: (919) 668-0349
Email: mark.oldham@duke.edu
Web: http://radonc.duke.edu/research-education/research-labs/radiation-physics/oldham-lab

Research Interests

Dr Oldham is Professor in the Department of Radiation Oncology (primary) and Biomedical Engineering (Secondary). He is the Director of the Optical Biophysics and 3D Dosimetry Lab. The lab has received NIH R01 funding to develop optical imaging techniques for 3D dosimetry. We are also developing a new optical imaging technique for high-resolution 3D imaging of vascular networks and gene expression in unsectioned tissue samples. A range of applications are being explored through collaborations with the Dept of Radiobiology (Prof Mark Dewhirst).  In addition to these efforts, the Lab is heavily involved in several research projects aimed at modifying radiation treatments in order to stimulate a long term anti-cancer immune response: radiation and immunotherapy. 

Dr Oldham is the Director of the Radiation Therapy Track of the Duke Medical Physics MS/PhD program.

Publications

Thomas, A; Oldham, M. Fast, large field-of-view, telecentric optical-CT scanning system for 3D radiochromic dosimetry. Journal of Physics. 2010;250:1-5. Abstract

Pierquet, M; Thomas, A; Adamovics, J; Oldham, M. An investigation into a new re-useable 3D radiochromic dosimetry material, Presage. Journal of Physics. 2010;250:1-4. Abstract

Baldock, C; De Deene, Y; Doran, S; Ibbott, G; Jirasek, A; Lepage, M; McAuley, KB; Oldham, M; Schreiner, LJ. Polymer gel dosimetry. Physics in Medicine and Biology. 2010;55:R1-63. Abstract

Brady, SL; Brown, WE; Clift, CG; Yoo, S; Oldham, M. Investigation into the feasibility of using PRESAGE/optical-CT dosimetry for the verification of gating treatments. Physics in Medicine and Biology. 2010;55:2187-2201. Abstract

Oldham, M; Clift, C; Thomas, A; Farfan, E; Foley, T; Jannik, T; Adamovics, J; Holmes, C; Stanley, S. Initial experience with optical-CT scanning of RadBall Dosimeters. Journal of Physics. 2010;250. Abstract

Grant, RL; Crowder, ML; Ibbott, GS; Simon, J; Frank, RK; Rogers, J; Loy, HM; Adamovics, J; Newton, J; Oldham, M; Stearns, S; Wendt, RE. Three-Dimensional Dosimetry of a Beta-Emitting Radionuclide Using PRESAGE Dosimeters. Journal of Physics. 2010;250. Abstract

Wang, Z; Thomas, A; Newton, J; Ibbott, G; Deasy, J; Oldham, M. Dose Verification of Stereotactic Radiosurgery Treatment for Trigeminal Neuralgia with Presage 3D Dosimetry System. Journal of Physics. 2010;250. Abstract

Stunja, L; Thomas, A; Adamovics, J; Deasy, J; Oldham, M. A 'quad-phantom' film dosimeter for use as a multi-planar verification tool for PRESAGE/optical-CT. Journal of Physics. 2010;250:12097. Abstract

Clift, C; Thomas, A; Adamovics, J; Chang, Z; Das, I; Oldham, M. Toward acquiring comprehensive radiosurgery field commissioning data using the PRESAGE/optical-CT 3D dosimetry system. Physics in Medicine and Biology. 2010;55:1279-1293. Abstract

Thomas, A; Bowsher, J; Roper, J; Oliver, T; Dewhirst, M; Oldham, M. A comprehensive method for optical-emission computed tomography. Physics in Medicine and Biology. 2010;55:3947-3957. Abstract

Thomas, A; Pierquet, M; Oldham, M. Achieving accurate radiochromic optical-CT imaging when using a polychromatic light source. Journal of Physics. 2010;250:210-214. Abstract

Newton, J; Thomas, A; Ibbott, G; Oldham, M. Preliminary commissioning investigations with the DMOS-RPC optical-CT Scanner. Journal of Physics. 2010;250:12078. Abstract

Sakhalkar, HS; Adamovics, J; Ibbott, G; Oldham, M. An Investigation into the Robustness of Optical-CT Dosimetry of a Radiochromic Dosimeter Compatible with the RPC Head-and-Neck Phantom. Journal of Physics. 2009;164:12059. Abstract

Sakhalkar, H; Sterling, D; Adamovics, J; Ibbott, G; Oldham, M. Investigating the Feasibility of 3D Dosimetry in the RPC IMRT H&N Phantom. Journal of Physics. 2009;164:12058. Abstract

Sakhalkar, HS; Adamovics, J; Ibbott, G; Oldham, M. A comprehensive evaluation of the PRESAGE/optical-CT 3D dosimetry system. Medical physics. 2009;36:71-82. Abstract

Sakhalkar, H; Sterling, D; Adamovics, J; Ibbott, G; Oldham, M. Investigation of the feasibility of relative 3D dosimetry in the Radiologic Physics Center Head and Neck IMRT phantom using presage/optical-CT. Medical physics. 2009;36:3371-3377. Abstract

Oldham, M; Sakhalkar, H; Oliver, T; Allan Johnson, G; Dewhirst, M. Optical clearing of unsectioned specimens for three-dimensional imaging via optical transmission and emission tomography. Journal of Biomedical Optics. 2008;13:021113. Abstract

Kim, E; Bowsher, J; Thomas, AS; Sakhalkar, H; Dewhirst, M; Oldham, M. Improving the quantitative accuracy of optical-emission computed tomography by incorporating an attenuation correction: application to HIF1 imaging. Physics in Medicine and Biology. 2008;53:5371-5383. Abstract

Oldham, M; Sakhalkar, H; Guo, P; Adamovics, J. An investigation of the accuracy of an IMRT dose distribution using two- and three-dimensional dosimetry techniques. Medical physics. 2008;35:2072-2080. Abstract

Sakhalkar, HS; Oldham, M. Fast, high-resolution 3D dosimetry utilizing a novel optical-CT scanner incorporating tertiary telecentric collimation. Medical physics. 2008;35:101-111. Abstract

Sakhalkar, HS; Dewhirst, M; Oliver, T; Cao, Y; Oldham, M. Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing. Physics in Medicine and Biology. 2007;52:2035-2054. Abstract

Oldham, M; Sakhalkar, H; Wang, YM; Guo, P; Oliver, T; Bentley, R; Vujaskovic, Z; Dewhirst, M. Three-dimensional imaging of whole rodent organs using optical computed and emission tomography. Journal of Biomedical Optics. 2007;12:014009. Abstract

Godfrey, DJ; Ren, L; Yan, H; Wu, Q; Yoo, S; Oldham, M; Yin, FF. Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS). Medical physics. 2007;34:3374-3384. Abstract

Guo, P; Adamovics, J; Oldham, M. A practical three-dimensional dosimetry system for radiation therapy. Medical physics. 2006;33:3962-3972. Abstract

Guo, P; Adamovics, J; Oldham, M. Quality assurance in 3D dosimetry by optical-CT. Journal of Physics. 2006;56:191-194. Abstract

Guo, PY; Adamovics, JA; Oldham, M. Characterization of a new radiochromic three-dimensional dosimeter. Medical physics. 2006;33:1338-1345. Abstract

Oldham, M; Guo, P; Adamovics, J; Sakhalkar, H; Wang, Z; Yin, F. Towards four dimensional (4D) dosimetry for radiation-therapy. Journal of Physics. 2006;56:225-227. Abstract

Godfrey, DJ; Yin, F-F; Oldham, M; Yoo, S; Willett, C. Digital tomosynthesis with an on-board kilovoltage imaging device. International Journal of Radiation Oncology, Biology, Physics. 2006;65:8-15. Abstract

Oldham, M; Guo, P; Gluckman, G; Adamovics, J. IMRT verification using a radiochromic/optical-CT dosimetry system. Journal of Physics. 2006;56:221-224. Abstract

Oldham, M; Sakhalkar, H; Oliver, T; Wang, YM; Kirpatrick, J; Cao, Y; Badea, C; Johnson, GA; Dewhirst, M. Three-dimensional imaging of xenograft tumors using optical computed and emission tomography. Medical physics. 2006;33:3193-3202. Abstract

Yin, F-F; Das, S; Kirkpatrick, J; Oldham, M; Wang, Z; Zhou, S-M. Physics and imaging for targeting of oligometastases. Seminars in Radiation Oncology. 2006;16:85-101. Abstract

Oldham, M. 3D dosimetry by optical-CT scanning. Journal of Physics. 2006;56:58-71. Abstract

Oldham, M; Sakhalkar, H; Guo, P. A dual-purpose CCD based micro-optical-CT scanning system. Journal of Physics. 2006;56:199-202. Abstract

Oldham, M; Létourneau, D; Watt, L; Hugo, G; Yan, D; Lockman, D; Kim, LH; Chen, PY; Martinez, A; Wong, JW. Cone-beam-CT guided radiation therapy: A model for on-line application. Radiotherapy & Oncology. 2005;75:271-278. Abstract

Létourneau, D; Wong, JW; Oldham, M; Gulam, M; Watt, L; Jaffray, DA; Siewerdsen, JH; Martinez, AA. Cone-beam-CT guided radiation therapy: technical implementation. Radiotherapy & Oncology. 2005;75:279-286. Abstract

Das, SK; Baydush, AH; Zhou, S; Miften, M; Yu, X; Craciunescu, O; Oldham, M; Light, K; Wong, T; Blazing, M; Borges-Neto, S; Dewhirst, MW; Marks, LB. Predicting radiotherapy-induced cardiac perfusion defects. Medical physics. 2005;32:19-27. Abstract

Oldham, M; Kim, L; Hugo, G. Optical-CT imaging of complex 3D dose distributions. Journal of Physics. 2005;5745:138-146. Abstract

Oldham, M; Kim, L. Optical-CT gel-dosimetry. II: Optical artifacts and geometrical distortion. Medical physics. 2004;31:1093-1104. Abstract

Oldham, M. Optical-CT scanning of polymer gels. Journal of Physics. 2004;3:122-135. Abstract

Létourneau, D; Gulam, M; Yan, D; Oldham, M; Wong, JW. Evaluation of a 2D diode array for IMRT quality assurance. Radiotherapy & Oncology. 2004;70:199-206. Abstract

Oldham, M; Siewerdsen, JH; Kumar, S; Wong, J; Jaffray, DA. Optical-CT gel-dosimetry I: basic investigations. Medical physics. 2003;30:623-634. Abstract

Oldham, M; Sapareto, SA; Li, XA; Allen, J; Sutlief, S; Wong, OC; Wong, JW. Practical aspects of in situ 16O (gamma,n) 15O activation using a conventional medical accelerator for the purpose of perfusion imaging. Medical physics. 2001;28:1669-1678. Abstract

Oldham, M; Siewerdsen, JH; Shetty, A; Jaffray, DA. High resolution gel-dosimetry by optical-CT and MR scanning. Medical physics. 2001;28:1436-1445. Abstract

McJury, M; Oldham, M; Cosgrove, VP; Murphy, PS; Doran, S; Leach, MO; Webb, S. Radiation dosimetry using polymer gels: methods and applications. British Journal of Radiology. 2000;73:919-929. Abstract

Low, DA; Markman, J; Dempsey, JF; Mutic, S; Oldham, M; Venkatesan, R; Haacke, EM; Purdy, JA. Noise in polymer gel measurements using MRI. Medical physics. 2000;27:1814-1817. Abstract

Baustert, IC; Oldham, M; Smith, TA; Hayes, C; Webb, S; Leach, MO. Optimized MR imaging for polyacrylamide gel dosimetry. Physics in Medicine and Biology. 2000;45:847-858. Abstract

McJury, M; Tapper, PD; Cosgrove, VP; Murphy, PS; Griffin, S; Leach, MO; Webb, S; Oldham, M. Experimental 3D dosimetry around a high-dose-rate clinical 192Ir source using a polyacrylamide gel (PAG) dosimeter. Physics in Medicine and Biology. 1999;44:2431-2444. Abstract

Bedford, JL; Khoo, VS; Oldham, M; Dearnaley, DP; Webb, S. A comparison of coplanar four-field techniques for conformal radiotherapy of the prostate. Radiotherapy & Oncology. 1999;51:225-235. Abstract

Khoo, VS; Oldham, M; Adams, EJ; Bedford, JL; Webb, S; Brada, M. Comparison of intensity-modulated tomotherapy with stereotactically guided conformal radiotherapy for brain tumors. International Journal of Radiation Oncology, Biology, Physics. 1999;45:415-425. Abstract

Rowbottom, CG; Webb, S; Oldham, M. Is it possible to optimize a radiotherapy treatment plan?. International Journal of Radiation Oncology, Biology, Physics. 1999;43:698-699. Abstract

Rowbottom, CG; Oldham, M; Webb, S. Constrained customization of non-coplanar beam orientations in radiotherapy of brain tumours. Physics in Medicine and Biology. 1999;44:383-399. Abstract

McJury, M; Oldham, M; Leach, MO; Webb, S. Dynamics of polymerization in polyacrylamide gel (PAG) dosimeters: (I) ageing and long-term stability. Physics in Medicine and Biology. 1999;44:1863-1873. Abstract

Rowbottom, CG; Webb, S; Oldham, M. Beam-orientation customization using an artificial neural network. Physics in Medicine and Biology. 1999;44:2251-2262. Abstract

Guzel, Z; Bedford, JL; Childs, PJ; Nahum, AE; Webb, S; Oldham, M; Tait, D. A comparison of conventional and conformal radiotherapy of the oesophagus: work in progress. British Journal of Radiology. 1998;71:1076-1082. Abstract

Oldham, M; McJury, M; Baustert, IB; Webb, S; Leach, MO. Improving calibration accuracy in gel dosimetry. Physics in Medicine and Biology. 1998;43:2709-2720. Abstract

Oldham, M; Khoo, VS; Rowbottom, CG; Bedford, JL; Webb, S. A case study comparing the relative benefit of optimizing beam weights, wedge angles, beam orientations and tomotherapy in stereotactic radiotherapy of the brain. Physics in Medicine and Biology. 1998;43:2123-2146. Abstract

Oldham, M; Baustert, I; Lord, C; Smith, TA; McJury, M; Warrington, AP; Leach, MO; Webb, S. An investigation into the dosimetry of a nine-field tomotherapy irradiation using BANG-gel dosimetry. Physics in Medicine and Biology. 1998;43:1113-1132. Abstract

Rowbottom, CG; Webb, S; Oldham, M. Improvements in prostate radiotherapy from the customization of beam directions. Medical physics. 1998;25:1171-1179. Abstract

Oldham, M; Webb, S. Intensity-modulated radiotherapy by means of static tomotherapy: a planning and verification study. Medical physics. 1997;24:827-836. Abstract

Bedford, JL; Oldham, M; Hoess, A; Evans, PM; Shentall, GS; Webb, S. Methods for transferring patient and plan data between radiotherapy treatment planning systems. British Journal of Radiology. 1997;70:740-749. Abstract

Webb, S; Oldham, M. A method to study the characteristics of 3D dose distributions created by superposition of many intensity-modulated beams delivered via a slit aperture with multiple absorbing vanes. Physics in Medicine and Biology. 1996;41:2135-2153. Abstract

Neal, AJ; Oldham, M; Dearnaley, DP. Comparison of treatment techniques for conformal radiotherapy of the prostate using dose-volume histograms and normal tissue complication probabilities. Radiotherapy & Oncology. 1995;37:29-34. Abstract

Oldham, M; Webb, S. The optimization and inherent limitations of 3D conformal radiotherapy treatment plans of the prostate. British Journal of Radiology. 1995;68:882-893. Abstract

Oldham, M; Neal, AJ; Webb, S. The optimisation of wedge filters in radiotherapy of the prostate. Radiotherapy & Oncology. 1995;37:209-220. Abstract

Oldham, M; Neal, A; Webb, S. A comparison of conventional 'forward planning' with inverse planning for 3D conformal radiotherapy of the prostate. Radiotherapy & Oncology. 1995;35:248-262. Abstract