Qiuwen Wu, PhD

Professor of Radiation Oncology
Department: Radiation Oncology
Division: Radiation Physics
Address: 00568 Duke South White Zone
Durham, NC 27710
Office Phone: (919) 613-6727
Email: qiuwen.wu@duke.edu

Research Interests

My research interests include intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), electron arc therapy (EAT) and image-guided radiation therapy (IGRT). For IMRT, my work include the development of the research platform, fast and accurate dose calculations, optimization based on physical and biological objectives such as generalized equivalent uniform dose (gEUD), and delivery with dynamic multi-leaf collimator (DMLC). For VMAT, I am interested in the optimization, quality assurance and novel applications. For EAT, I'm interested in the treatment planning and delivery verifications. For IGRT, my work include development of the infrastructure of the online and offline image guidance, characterization of patient anatomic changes and treatment uncertainties, margin calculations, and adaptive treatment planning.

My clinical interests include prostate cancer, head and neck cancer, breast cancer and lung cancer.

Publications

Yoo, S; O'Daniel, J; Blitzblau, R; Wu, Q; Yin, F; Horton, J. Partial Breast Extracranial Radiosurgery: A Dosimetric Evaluation of Treatment Delivery Accuracy. International Journal of Radiation Oncology, Biology, Physics. S243-S243.

Liu, H; Wu, Q. A "rolling average" multiple adaptive planning method to compensate for target volume changes in image-guided radiotherapy of prostate cancer. Journal of applied clinical medical physics / American College of Medical Physics. 2012;13:3697. Abstract

Song, H; Salama, J; Yoo, D; Oleson, J; Wu, Q. Prostate Bed Motion Study Using Surgical Clips Based On Daily CBCT. Medical physics. 3657-3657.

Chang, Z; Wu, Q; Adamson, J; Ren, L; Bowsher, J; Yan, H; Thomas, A; Yin, F-F. Commissioning and dosimetric characteristics of TrueBeam system: composite data of three TrueBeam machines. Medical physics. 2012;39:6981-7018. Abstract

Chang, Z; Wu, Q; Adamson, J; Ren, L; Bowsher, J; Yan, H; Thomas, A; Yin, F. Commissioning and Dosimetric Characteristics of TrueBeam System: Composite Data of Three TrueBeam Machines. Medical physics. 3726-3726.

Wu, Q; Yoo, S; Das, S; Yin, F. Evaluation of IMRT and VMAT for Head-and-Neck Cancer With Flattening Filter-free (FFF) Beams. International Journal of Radiation Oncology, Biology, Physics. S863-S863.

Chen, Q; Cai, J; Wu, Q; Yin, F. Dosimetric Evaluation of Flattening Filter-free (FFF) Photon Beams for Lung SBRT. International Journal of Radiation Oncology, Biology, Physics. S609-S609.

Chang, Z; Wu, Q; Adamson, J; Ren, L; Bowsher, J; Yan, H; Thomas, A; Yin, F. Assessing Effects of Ion Collection Efficiency in Flattening Filter-Free (FFF) Beams On Three TrueBeam Machines. Medical physics. 3719-3719.

Liu, H; Wu, Q. A "rolling average" multiple adaptive planning method to compensate for target volume changes in image-guided radiotherapy of prostate cancer. Journal of applied clinical medical physics / American College of Medical Physics. 2012;13:124-137.

Song, H; Salama, J; Yoo, D; Oleson, J; Wu, Q. Study of Prostate Bed Motion Using Daily CBCT and Surgical Clips. International Journal of Radiation Oncology, Biology, Physics. S741-S742.

Wu, Q; Yoo, S; Das, S; Yin, F. Evaluation of Flatening Filter Free (FFF) Beams in Radiotherapy of Head and Neck Cancer. Medical physics. 3834-3834.

Ashmeg, S; O'Daniel, J; Wu, Q; Yin, F. Benchmarking Flattening-Filter Free Photons for IMRT/VMAT. Medical physics. 4011-4011.

Gopan, O; Wu, Q. Evaluation of the accuracy of a 3D surface imaging system for patient setup in head and neck cancer radiotherapy. International Journal of Radiation: Oncology - Biology - Physics. 2012;84:547-552. Abstract

Adamson, J; Wu, Q. Independent verification of gantry angle for pre-treatment VMAT QA using EPID. Physics in Medicine and Biology. 2012;57:6587-6600. Abstract

Li, T; Yuan, L; Wu, Q; Yin, F; Wu, QJ. Treatment Delivery QA for Online Adaptive Radiation Therapy Based On Dynamic Machine Information (DMI): A Feasibility Study. Medical physics. 3867-3868.

Yoo, S; Wu, Q; O'Daniel, J; Horton, J; Yin, F-F. Comparison of 3D conformal breast radiation treatment plans using the anisotropic analytical algorithm and pencil beam convolution algorithm. Radiotherapy and Oncology. 2012;103:172-177. Abstract

Liu, H; Wu, Q. Dosimetric and geometric evaluation of a hybrid strategy of offline adaptive planning and online image guidance for prostate cancer radiotherapy. Physics in Medicine and Biology. 2011;56:5045-5062. Abstract

Liu, H; Wu, Q. Evaluations of an adaptive planning technique incorporating dose feedback in image-guided radiotherapy of prostate cancer. Medical physics. 2011;38:6362-6370. Abstract

Wu, QJ; Li, T; Wu, Q; Yin, F-F. Adaptive radiation therapy: technical components and clinical applications. Cancer Journal. 2011;17:182-189. Abstract

Wu, Q; Liu, H. The Role of Offline Adaptive Planning in Online Image Guided Radiation Therapy of Prostate Cancer. International Journal of Radiation Oncology, Biology, Physics. 2011;81:S836-S836.

Adamson, J; Wu, Q; Yan, D. Dosimetric effect of intrafraction motion and residual setup error for hypofractionated prostate intensity-modulated radiotherapy with online cone beam computed tomography image guidance. International Journal of Radiation: Oncology - Biology - Physics. 2011;80:453-461. Abstract

Adamson, J; Wu, Q. Prostate intrafraction motion assessed by simultaneous kV fluoroscopy at MV delivery II: adaptive strategies. International Journal of Radiation: Oncology - Biology - Physics. 2010;78:1323-1330. Abstract

Yoo, S; Wu, Q; O'Daniel, J; Horton, J; Yin, F. Breast Cancer Radiation Treatment Planning: A Comparison of Anisotropic Analytical Algorithm (AAA) and Pencil Beam Convolution (PBC) Algorithm. International Journal of Radiation Oncology, Biology, Physics. S240-S240.

Worthy, D; Wu, Q. Dosimetric assessment of rigid setup error by CBCT for HN-IMRT. Journal of applied clinical medical physics / American College of Medical Physics. 2010;11:3187. Abstract

Li, T; Zhu, X; Thongphiew, D; Lee, WR; Vujaskovic, Z; Wu, Q; Yin, F-F; Wu, QJ. On-line adaptive radiation therapy: feasibility and clinical study. Journal of Oncology. 2010;2010:407236. Abstract

Adamson, JD; Yoo, S; Wu, Q; Yin, F. Variation of Clinically Relevant Dose Indices for 3DCRT of Lung with Respect to Dose Calculation Algorithm. International Journal of Radiation Oncology, Biology, Physics. S712-S713.

Wang, W; Wu, Q; Yan, D. Quantitative evaluation of cone-beam computed tomography in target volume definition for offline image-guided radiation therapy of prostate cancer. Radiotherapy and Oncology. 2010;94:71-75. Abstract

Worthy, D; Wu, Q. Dosimetric assessment of rigid setup error by CBCT for HN-IMRT. Journal of applied clinical medical physics / American College of Medical Physics. 2010;11:38-53.

Lei, Y; Wu, Q. A hybrid strategy of offline adaptive planning and online image guidance for prostate cancer radiotherapy. Physics in Medicine and Biology. 2010;55:2221-2234. Abstract

Adamson, J; Wu, Q. Prostate intrafraction motion assessed by simultaneous kilovoltage fluoroscopy at megavoltage delivery I: clinical observations and pattern analysis. International Journal of Radiation: Oncology - Biology - Physics. 2010;78:1563-1570. Abstract

Zhuang, T; Wu, Q. Generating arbitrary one-dimensional dose profiles using rotational therapy. Physics in Medicine and Biology. 2010;55:6263-6277. Abstract

Yin, F-F; Oldham, M; Cai, J; Wu, Q. Dosimetry challenges for implementing emerging technologies. Journal of Physics. 2010;250:8-11. Abstract

Worthy, D; Wu, Q. Parameter optimization in HN-IMRT for Elekta linacs. Journal of applied clinical medical physics / American College of Medical Physics. 2009;10:43-61.

Worthy, D; Wu, Q. Parameter optimization in HN-IMRT for Elekta linacs. Journal of applied clinical medical physics / American College of Medical Physics. 2009;10:2951. Abstract

Liang, J; Wu, Q; Yan, D. The role of seminal vesicle motion in target margin assessment for online image-guided radiotherapy for prostate cancer. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:935-943. Abstract

Adamson, JD; Wu, Q; Yan, D. Adaptive Management of Intrafraction Motion in Online Image Guided Prostate Cancer Radiotherapy. International Journal of Radiation Oncology, Biology, Physics. S628-S629.

Adamson, J; Wu, Q. Optimizing monoscopic kV fluoro acquisition for prostate intrafraction motion evaluation. Physics in Medicine and Biology. 2009;54:117-133. Abstract

Adamson, J; Wu, Q. Inferences about prostate intrafraction motion from pre- and posttreatment volumetric imaging. International Journal of Radiation: Oncology - Biology - Physics. 2009;75:260-267. Abstract

Wu, Q; Chi, Y; Chen, PY; Krauss, DJ; Yan, D; Martinez, A. Adaptive replanning strategies accounting for shrinkage in head and neck IMRT. International Journal of Radiation: Oncology - Biology - Physics. 2009;75:924-932. Abstract

Adamson, J; Wu, Q. Prostate intrafraction motion evaluation using kV fluoroscopy during treatment delivery: a feasibility and accuracy study. Medical physics. 2008;35:1793-1806. Abstract

Wu, Q; Lockman, D; Wong, J; Yan, D. Effect of the first day correction on systematic setup error reduction. Medical physics. 2007;34:1789-1796. Abstract

Sakthi, N; Keall, P; Mihaylov, I; Wu, Q; Wu, Y; Williamson, JF; Schmidt-Ullrich, R; Siebers, JV. Monte Carlo-based dosimetry of head-and-neck patients treated with SIB-IMRT. International Journal of Radiation Oncology, Biology, Physics. 2006;64:968-977. Abstract

Wu, Q; Liang, J; Yan, D. Application of dose compensation in image-guided radiotherapy of prostate cancer. Physics in Medicine and Biology. 2006;51:1405-1419. Abstract

Wu, Q; Ivaldi, G; Liang, J; Lockman, D; Yan, D; Martinez, A. Geometric and dosimetric evaluations of an online image-guidance strategy for 3D-CRT of prostate cancer. International Journal of Radiation Oncology, Biology, Physics. 2006;64:1596-1609. Abstract

Djajaputra, D; Wu, Q. On relating the generalized equivalent uniform dose formalism to the linear-quadratic model. Medical physics. 2006;33:4481-4489. Abstract

Siebers, JV; Keall, PJ; Wu, Q; Williamson, JF; Schmidt-Ullrich, RK. Effect of patient setup errors on simultaneously integrated boost head and neck IMRT treatment plans. International Journal of Radiation Oncology, Biology, Physics. 2005;63:422-433. Abstract

Wu, Q; Djajaputra, D; Liu, HH; Dong, L; Mohan, R; Wu, Y. Dose sculpting with generalized equivalent uniform dose. Medical physics. 2005;32:1387-1396. Abstract

Zhang, X; Liu, H; Wang, X; Dong, L; Wu, Q; Mohan, R. Speed and convergence properties of gradient algorithms for optimization of IMRT. Medical physics. 2004;31:1141-1152. Abstract

Liu, HH; Wang, X; Dong, L; Wu, Q; Liao, Z; Stevens, CW; Guerrero, TM; Komaki, R; Cox, JD; Mohan, R. Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non-small-cell lung cancer. International Journal of Radiation Oncology, Biology, Physics. 2004;58:1268-1279. Abstract

Wang, X; Zhang, X; Dong, L; Liu, H; Wu, Q; Mohan, R. Development of methods for beam angle optimization for IMRT using an accelerated exhaustive search strategy. International Journal of Radiation Oncology, Biology, Physics. 2004;60:1325-1337. Abstract

Wu, Q. A dose calculation method including scatter for IMRT optimization. Physics in Medicine and Biology. 2004;49:4611-4621. Abstract

Lauve, A; Morris, M; Schmidt-Ullrich, R; Wu, Q; Mohan, R; Abayomi, O; Buck, D; Holdford, D; Dawson, K; Dinardo, L; Reiter, E. Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II--clinical results. International Journal of Radiation Oncology, Biology, Physics. 2004;60:374-387. Abstract

Djajaputra, D; Wu, Q; Wu, Y; Mohan, R. Algorithm and performance of a clinical IMRT beam-angle optimization system. Physics in Medicine and Biology. 2003;48:3191-3212. Abstract

Kavanagh, BD; Timmerman, RD; Benedict, SH; Wu, Q; Schefter, TE; Stuhr, K; McCourt, S; Newman, F; Cardinale, RM; Gaspar, LF. How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability?. Medical physics. 2003;30:321-324. Abstract

George, R; Keall, PJ; Kini, VR; Vedam, SS; Siebers, JV; Wu, Q; Lauterbach, MH; Arthur, DW; Mohan, R. Quantifying the effect of intrafraction motion during breast IMRT planning and dose delivery. Medical physics. 2003;30:552-562. Abstract

Zhou, J; Fei, D; Wu, Q. Potential of intensity-modulated radiotherapy to escalate doses to head-and-neck cancers: what is the maximal dose?. International Journal of Radiation Oncology, Biology, Physics. 2003;57:673-682. Abstract

Wu, Q; Mohan, R; Morris, M; Lauve, A; Schmidt-Ullrich, R. Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results. International Journal of Radiation Oncology, Biology, Physics. 2003;56:573-585. Abstract

Wu, Q; Djajaputra, D; Lauterbach, M; Wu, Y; Mohan, R. A fast dose calculation method based on table lookup for IMRT optimization. Physics in Medicine and Biology. 2003;48:N159-N166. Abstract

Wu, Q; Djajaputra, D; Wu, Y; Zhou, J; Liu, HH; Mohan, R. Intensity-modulated radiotherapy optimization with gEUD-guided dose-volume objectives. Physics in Medicine and Biology. 2003;48:279-291. Abstract

Siebers, JV; Lauterbach, M; Tong, S; Wu, Q; Mohan, R. Reducing dose calculation time for accurate iterative IMRT planning. Medical physics. 2002;29:231-237. Abstract

Kavanagh, BD; Schefter, TE; Wu, Q; Tong, S; Newman, F; Arnfield, M; Benedict, SH; McCourt, S; Mohan, R. Clinical application of intensity-modulated radiotherapy for locally advanced cervical cancer. Seminars in Radiation Oncology. 2002;12:260-271. Abstract

Wu, Q; Mohan, R. Multiple local minima in IMRT optimization based on dose-volume criteria. Medical physics. 2002;29:1514-1527. Abstract

Schefter, TE; Kavanagh, BD; Wu, Q; Tong, S; Newman, F; Mccourt, S; Arnfield, M; Benedict, S; Mohan, R. Technical considerations in the application of intensity-modulated radiotherapy as a concomitant integrated boost for locally-advanced cervix cancer. Medical Dosimetry. 2002;27:177-184. Abstract

Wu, Q; Mohan, R; Niemierko, A; Schmidt-Ullrich, R. Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose. International Journal of Radiation Oncology, Biology, Physics. 2002;52:224-235. Abstract

Siebers, JV; Tong, S; Lauterbach, M; Wu, Q; Mohan, R. Acceleration of dose calculations for intensity-modulated radiotherapy. Medical physics. 2001;28:903-910. Abstract

Arnfield, MR; Wu, Q; Tong, S; Mohan, R. Dosimetric validation for multileaf collimator-based intensity-modulated radiotherapy: a review. Medical Dosimetry. 2001;26:179-188. Abstract

Manning, MA; Wu, Q; Cardinale, RM; Mohan, R; Lauve, AD; Kavanagh, BD; Morris, MM; Schmidt-Ullrich, RK. The effect of setup uncertainty on normal tissue sparing with IMRT for head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics. 2001;51:1400-1409. Abstract

Benedict, SH; Cardinale, RM; Wu, Q; Zwicker, RD; Broaddus, WC; Mohan, R. Intensity-modulated stereotactic radiosurgery using dynamic micro-multileaf collimation. International Journal of Radiation Oncology, Biology, Physics. 2001;50:751-758. Abstract

Wu, Q; Arnfield, M; Tong, S; Wu, Y; Mohan, R. Dynamic splitting of large intensity-modulated fields. Physics in Medicine and Biology. 2000;45:1731-1740. Abstract

Wu, Q; Mohan, R. Algorithms and functionality of an intensity modulated radiotherapy optimization system. Medical physics. 2000;27:701-711. Abstract

Mohan, R; Arnfield, M; Tong, S; Wu, Q; Siebers, J. The impact of fluctuations in intensity patterns on the number of monitor units and the quality and accuracy of intensity modulated radiotherapy. Medical physics. 2000;27:1226-1237. Abstract

Mohan, R; Cardinale, RM; Wu, Q; Benedict, S. Intensity-modulated stereotactic radiosurgery. Frontiers of Radiation Therapy and Oncology. 2000;34:40-48.

Wu, Q; Manning, M; Schmidt-Ullrich, R; Mohan, R. The potential for sparing of parotids and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers: a treatment design study. International Journal of Radiation Oncology, Biology, Physics. 2000;46:195-205. Abstract

Arnfield, MR; Siebers, JV; Kim, JO; Wu, Q; Keall, PJ; Mohan, R. A method for determining multileaf collimator transmission and scatter for dynamic intensity modulated radiotherapy. Medical physics. 2000;27:2231-2241. Abstract

Mohan, R; Wu, Q; Manning, M; Schmidt-Ullrich, R. Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. International Journal of Radiation Oncology, Biology, Physics. 2000;46:619-630. Abstract

Wu, Q; Mohan, R; Niemierko, A. IMRT optimization based on the generalized equivalent uniform dose (EUD). 2000;1:710-713.

Cardinale, RM; Wu, Q; Benedict, SH; Kavanagh, BD; Bump, E; Mohan, R. Determining the optimal block margin on the planning target volume for extracranial stereotactic radiotherapy. International Journal of Radiation Oncology, Biology, Physics. 1999;45:515-520. Abstract

Cardinale, RM; Benedict, SH; Wu, Q; Zwicker, RD; Gaballa, HE; Mohan, R. A comparison of three stereotactic radiotherapy techniques; ARCS vs. noncoplanar fixed fields vs. intensity modulation. International Journal of Radiation Oncology, Biology, Physics. 1998;42:431-436. Abstract

Mohan, R; Mageras, G; Wu, Q. Computer-controlled delivery of 3D conformal radiation treatments. Cancer Treatment and Research. 1998;93:49-67. Abstract

Burman, C; Chui, CS; Kutcher, G; Leibel, S; Zelefsky, M; LoSasso, T; Spirou, S; Wu, Q; Yang, J; Stein, J; Mohan, R; Fuks, Z; Ling, CC. Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: a strategy for large-scale implementation for the treatment of carcinoma of the prostate. International Journal of Radiation Oncology, Biology, Physics. 1997;39:863-873. Abstract

Stein, J; Mohan, R; Wang, XH; Bortfeld, T; Wu, Q; Preiser, K; Ling, CC; Schlegel, W. Number and orientations of beams in intensity-modulated radiation treatments. Medical physics. 1997;24:149-160. Abstract

Ling, CC; Burman, C; Chui, CS; Kutcher, GJ; Leibel, SA; LoSasso, T; Mohan, R; Bortfeld, T; Reinstein, L; Spirou, S; Wang, XH; Wu, Q; Zelefsky, M; Fuks, Z. Conformal radiation treatment of prostate cancer using inversely-planned intensity-modulated photon beams produced with dynamic multileaf collimation. International Journal of Radiation Oncology, Biology, Physics. 1996;35:721-730. Abstract

Mohan, R; Wu, Q; Wang, X; Stein, J. Intensity modulation optimization, lateral transport of radiation, and margins. Medical physics. 1996;23:2011-2021. Abstract