Ronald Jaszczak, PhD

Professor Emeritus in the Department of Radiology
Department: Radiology
Division: Radiology - General
Address: 2919 Reynolda Circle
Durham, NC 27712
Office Phone: (919) 810-7700
Email: r.jaszczak@ieee.org

Research Interests

We currently have a large effort in quantitative nuclear medicine imaging, specifically in SPECT. This research covers basic instrumentation development, investigation and development of new image reconstruction algorithms, simulations, and evaluation of new quantitative techniques. Quantitation has been an ongoing topic of research in our group, and requires understanding of the physical phenomena involved in SPECT acquisition. Photon attenuation, scatter, limited spatial resolution, and image noise all contribute to the inherent quantitative inaccuracy in SPECT images, and must be compensated for. Our group is investigating ways to solve these problems through improved hardware, simulation and reconstruction.

A major thrust of research in our group concerns improving imaging methods for evaluating myocardial perfusion and breast tumor characterization using Technetium-99, the most widely used nuclide. Our group has investigated alternate collimator design (fan-beam, half cone-beam, pinhole and astigmatic geometries), simulation methods, iterative reconstruction techniques, visualization, receiver operating characteristics (ROC) analysis, and correlation of images with other imaging modalities. Alternate collimator designs can improve the number of photons detected and therby reduce image noise, or in the case of pinhole collimation, can be used to magnify images significantly, increasing the effective resolution for small objects.

We have developed and tested new filtered backprojection and iterative reconstruction methods that model non-uniform attenuation and distance-dependent detectors response. Iterative reconstruction methods, although computationally time consuming, allow proper correction for the degrading effects. We have performed Monte Carlo simulation to determine collimator and reconstruction properties which cannot be measured easily. Simulation provides a way to divide the degrading physical effects into components for separate study. Both converging beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced.

Publications

Zhang, J; Ma, J; Zhou, S; Hubbs, JL; Wong, TZ; Folz, RJ; Evans, ES; Jaszczak, RJ; Clough, R; Marks, LB. Radiation-induced reductions in regional lung perfusion: 0.1-12 year data from a prospective clinical study. International Journal of Radiation: Oncology - Biology - Physics. 2010;76:425-432. Abstract

Metzler, SD; Vemulapalli, S; Jaszczak, RJ; Akabani, G; Chin, BB. Feasibility of whole-body functional mouse imaging using helical pinhole SPECT. Molecular Imaging and Biology. 2010;12:35-41. Abstract

Ter-Antonyan, R; Jaszczak, RJ; Greer, KL; Bowsher, JE; Metzler, SD; Coleman, RE. Combination of converging collimators for high-sensitivity brain SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2009;50:1548-1556. Abstract

Ter-Antonyan, R; Jaszczak, RJ; Bowsher, JE; Greer, KL; Metzler, SD. Quantitative Evaluation of Half-Cone-Beam Scan Paths in Triple-Camera Brain SPECT. IEEE Transactions on Nuclear Science. 2008;55:2518-2526. Abstract

Vemulapalli, S; Metzler, SD; Akabani, G; Petry, NA; Niehaus, NJ; Liu, X; Patil, NH; Greer, KL; Jaszczak, RJ; Coleman, RE; Dong, C; Goldschmidt-Clermont, PJ; Chin, BB. Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECT. Radiology. 2007;242:198-207. Abstract

Chin, BB; Metzler, SD; Lemaire, A; Curcio, A; Vemulapalli, S; Greer, KL; Petry, NA; Turkington, TG; Coleman, RE; Rockman, H; Jaszczak, RJ. Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT. Radiology. 2007;245:440-448. Abstract

Ter-Antonyan, R; Jaszczak, RJ; Bowsher, JE; Greer, KL; Metzler, SD. Brain SPECT Simulation Using Half-Cone-Beam Collimation and Single-Revolution Helical-Path Acquisition. IEEE Transactions on Nuclear Science. 2007;54:475-479. Abstract

Metzler, SD; Accorsi, R; Novak, JR; Ayan, AS; Jaszczak, RJ. On-axis sensitivity and resolution of a slit-slat collimator. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2006;47:1884-1890. Abstract

Jaszczak, RJ. The early years of single photon emission computed tomography (SPECT): an anthology of selected reminiscences. Physics in Medicine and Biology. 2006;51:R99-115. Abstract

Metzler, SD; Greer, KL; Jaszczak, RJ. Determination of mechanical and electronic shifts for pinhole SPECT using a single point source. IEEE Transactions on Medical Imaging. 2005;24:361-370. Abstract

Metzler, SD; Jaszczak, RJ; Patil, NH; Vemulapalli, S; Akabani, G; Chin, BB. Molecular imaging of small animals with a triple-head SPECT system using pinhole collimation. IEEE Transactions on Medical Imaging. 2005;24:853-862. Abstract

Tornai, MP; Bowsher, JE; Jaszczak, RJ; Pieper, BC; Greer, KL; Hardenbergh, PH; Coleman, RE. Mammotomography with pinhole incomplete circular orbit SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2003;44:583-593. Abstract

Woel, RT; Munley, MT; Hollis, D; Fan, M; Bentel, G; Anscher, MS; Shafman, T; Coleman, RE; Jaszczak, RJ; Marks, LB. The time course of radiation therapy-induced reductions in regional perfusion: a prospective study with >5 years of follow-up. International Journal of Radiation Oncology, Biology, Physics. 2002;52:58-67. Abstract

Bowsher, JE; Tornai, MP; Peter, J; González Trotter, DE; Krol, A; Gilland, DR; Jaszczak, RJ. Modeling the axial extension of a transmission line source within iterative reconstruction via multiple transmission sources. IEEE Transactions on Medical Imaging. 2002;21:200-215. Abstract

Metzler, SD; Bowsher, JE; Greer, KL; Jaszczak, RJ. Analytic determination of the pinhole collimator's point-spread function and RMS resolution with penetration. IEEE Transactions on Medical Imaging. 2002;21:878-887. Abstract

Lind, PA; Marks, LB; Hollis, D; Fan, M; Zhou, S-M; Munley, MT; Shafman, TD; Jaszczak, RJ; Coleman, RE. Receiver operating characteristic curves to assess predictors of radiation-induced symptomatic lung injury. International Journal of Radiation Oncology, Biology, Physics. 2002;54:340-347. Abstract

Metzler, SD; Bowsher, JE; Smith, MF; Jaszczak, RJ. Analytic determination of pinhole collimator sensitivity with penetration. IEEE Transactions on Medical Imaging. 2001;20:730-741. Abstract

LaCroix, KJ; Tsui, BM; Frey, EC; Jaszczak, RJ. Receiver operating characteristic evaluation of iterative reconstruction with attenuation correction in 99mTc-sestamibi myocardial SPECT images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2000;41:502-513. Abstract

Munley, MT; Marks, LB; Scarfone, C; Sibley, GS; Patz, EF; Turkington, TG; Jaszczak, RJ; Gilland, DR; Anscher, MS; Coleman, RE. Multimodality nuclear medicine imaging in three-dimensional radiation treatment planning for lung cancer: challenges and prospects. Lung Cancer. 1999;23:105-114. Abstract

Tornai, MP; Jaszczak, RJ; Turkington, TG; Coleman, RE. Small-animal PET: advent of a new era of PET research. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1999;40:1176-1179. Abstract

Scarfone, C; Jaszczak, RJ; Gilland, DR; Greer, KL; Munley, MT; Marks, LB; Coleman, RE. Quantitative pulmonary single photon emission computed tomography for radiotherapy applications. Medical physics. 1999;26:1579-1588. Abstract

Scarfone, C; Jaszczak, RJ; Li, J; Soo, MS; Smith, MF; Greer, KL; Coleman, RE. Breast tumour imaging using incomplete circular orbit pinhole SPET: a phantom study. Nuclear Medicine Communications. 1997;18:1077-1086. Abstract

Li, J; Jaszczak, RJ; Greer, KL; Gilland, DR; DeLong, DM; Coleman, RE. Evaluation of SPECT quantification of radiopharmaceutical distribution in canine myocardium. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1995;36:278-286. Abstract

Gilland, DR; Jaszczak, RJ; Turkington, TG; Greer, KL; Coleman, RE. Volume and activity quantitation with iodine-123 SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1994;35:1707-1713. Abstract

Jaszczak, RJ; Gilland, DR; Hanson, MW; Jang, S; Greer, KL; Coleman, RE. Fast transmission CT for determining attenuation maps using a collimated line source, rotatable air-copper-lead attenuators and fan-beam collimation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1993;34:1577-1586. Abstract

Jaszczak, RJ; Li, J; Wang, H; Coleman, RE. Three-dimensional SPECT reconstruction of combined cone beam and parallel beam data. Physics in Medicine and Biology. 1992;37:535-548. Abstract

Jaszczak, RJ; Greer, KL; Coleman, RE. SPECT using a specially designed cone beam collimator. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1988;29:1398-1405. Abstract

Jaszczak, RJ; Floyd, CE; Manglos, SH; Greer, KL; Coleman, RE. Cone beam collimation for single photon emission computed tomography: analysis, simulation, and image reconstruction using filtered backprojection. Medical physics. 1986;13:484-489. Abstract

Jaszczak, RJ; Coleman, RE. Single photon emission computed tomography (SPECT). Principles and instrumentation. Investigative Radiology. 1985;20:897-910. Abstract

Jaszczak, RJ; Greer, KL; Floyd, CE; Harris, CC; Coleman, RE. Improved SPECT quantification using compensation for scattered photons. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1984;25:893-900. Abstract

Jaszczak, RJ. Physical characteristics of SPECT systems, September, 1982. Journal of Computer Assisted Tomography. 1982;6:1205-1215. Abstract

Jaszczak, RJ; Whitehead, FR; Lim, CB; Coleman, RE. Lesion detection with single-photon emission computed tomography (SPECT) compared with conventional imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1982;23:97-102. Abstract

Jaszczak, RJ; Chang, LT; Stein, NA; Moore, FE. Whole-body single-photon emission computed tomography using dual, large-field-of-view scintillation cameras. Physics in Medicine and Biology. 1979;24:1123-1143. Abstract

Jaszczak, RJ; Murphy, PH; Huard, D; Burdine, JA. Radionuclide emission computed tomography of the head with 99mCc and a scintillation camera. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1977;18:373-380. Abstract

Jaszczak, RJ. Line spread response for a scintillation camera and movable filter plate system. Physics in Medicine and Biology. 1974;19:362-372. Abstract

Jaszczak, RJ. Increased resolving power from scintillation cameras using electronic signal processing and a movable filter plate. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1973;14:14-20. Abstract