Nan-Kuei Chen, PhD

Address: 40 Duke Medicine Circle, Davison 414, Box 3918
Durham, NC 27710
Phone: (919) 613-6207

Research Interests

Dr. Chen is a magnetic resonance imaging (MRI) physicist with research interest in fast image acquisition methodology, pulse sequence design, MRI artifact correction, and application of MRI to studies of neurological diseases. He has been developing novel high-resolution imaging protocols and analysis procedures for mapping structural and functional connectivity of brains. More generally, Dr. Chen's research involves the application of MRI in translational contexts. He has been serving as the principal investigator on NIH-funded R01, R21 and R03 grants, and has had extensive experience as a co-investigator on NIH-funded projects.


Bernstein, Adam S., et al. “Bootstrap analysis of diffusion tensor and mean apparent propagator parameters derived from multiband diffusion MRI.Magn Reson Med, vol. 82, no. 5, Nov. 2019, pp. 1796–803. Pubmed, doi:10.1002/mrm.27833.

Chen, Nan-Kuei, and Pei-Hsin Wu. “The use of Fourier-domain analyses for unwrapping phase images of low SNR.Magn Reson Med, vol. 82, no. 1, July 2019, pp. 356–66. Pubmed, doi:10.1002/mrm.27719.

Sonderer, Christa M., and Nan-Kuei Chen. “Improving the Accuracy, Quality, and Signal-To-Noise Ratio of MRI Parametric Mapping Using Rician Bias Correction and Parametric-Contrast-Matched Principal Component Analysis (PCM-PCA).Yale J Biol Med, vol. 91, no. 3, Sept. 2018, pp. 207–14.

Bell, Ryan P., et al. “Structural connectome differences in HIV infection: brain network segregation associated with nadir CD4 cell count.J Neurovirol, vol. 24, no. 4, Aug. 2018, pp. 454–63. Pubmed, doi:10.1007/s13365-018-0634-4.

Chen, Nan-Kuei, et al. “Alteration of Diffusion-Tensor Magnetic Resonance Imaging Measures in Brain Regions Involved in Early Stages of Parkinson's Disease.Brain Connect, vol. 8, no. 6, Aug. 2018, pp. 343–49. Pubmed, doi:10.1089/brain.2017.0558.

Chang, Hing-Chiu, et al. “Phase correction for three-dimensional (3D) diffusion-weighted interleaved EPI using 3D multiplexed sensitivity encoding and reconstruction (3D-MUSER).Magn Reson Med, vol. 79, no. 5, May 2018, pp. 2702–12. Pubmed, doi:10.1002/mrm.26944.

Meade, Christina S., et al. “Cocaine and HIV are independently associated with neural activation in response to gain and loss valuation during economic risky choice.Addict Biol, vol. 23, no. 2, Mar. 2018, pp. 796–809. Pubmed, doi:10.1111/adb.12529.

Zhuang, Jie, et al. “Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere.Neurobiol Aging, vol. 63, Mar. 2018, pp. 65–74. Pubmed, doi:10.1016/j.neurobiolaging.2017.11.003.