Joseph Izatt, PhD

Michael J. Fitzpatrick Distinguished Professor of Engineering in the Edmund T. Pratt, Jr. School of Engineering
Professor of Biomedical Engineering
Professor in Ophthalmology
Faculty Network Member of the Duke Institute for Brain Sciences
Core Faculty in Innovation & Entrepreneurship
Address: 1427 Fciemas, Box 90281
Durham, NC 27708
Phone: (919) 660-5128

Research Interests

My research centers on the development and application of cutting-edge optical technologies for non-invasive, high-resolution imaging and sensing in living biological tissues. Our laboratory is recognized for foundational contributions to optical coherence-based approaches for in vivo sub-surface microscopic tissue imaging, particularly optical coherence tomography (OCT) which has become a standard of care in ophthalmology and other clinical specialties. The technologies we employ include adaptive-optic devices, femtosecond lasers, ultrabroadband fiber optic telecommunications equipment, robots and robotic manipulators, high performance computing, and 3D display technologies. Together with our collaborators, we have developed and deployed multiple hand-held and intrasurgical systems for real-time volumetric imaging of the human eye, visualized using virtual/augmented reality displays and coupled to image-guided robotic microsurgical procedures. Our research team includes a rich and diverse group of highly motivated and productive undergraduate, MS and PhD students, staff and associated faculty along with multiple collaborations with engineers, biologists, and physicians at Duke and elsewhere.


Edwards, W., et al. “Data-Driven Modelling and Control for Robot Needle Insertion in Deep Anterior Lamellar Keratoplasty (Accepted).” Ieee Robotics and Automation Letters, vol. 7, no. 2, Apr. 2022, pp. 1526–33. Scopus, doi:10.1109/LRA.2022.3140458.

Zhou, K. C., et al. “High-speed multiview imaging approaching 4pi steradians using conic section mirrors: Theoretical and practical considerations.” Journal of the Optical Society of America A: Optics and Image Science, and Vision, vol. 38, no. 12, Dec. 2021, pp. 1810–22. Scopus, doi:10.1364/JOSAA.440592.

Ortiz, Pablo, et al. “Robotically aligned optical coherence tomography with 5 degree of freedom eye tracking for subject motion and gaze compensation.Biomed Opt Express, vol. 12, no. 12, Dec. 2021, pp. 7361–76. Pubmed, doi:10.1364/BOE.443537.

Patel, Pujan R., et al. “Depth-Resolved Visualization of Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography.Transl Vis Sci Technol, vol. 10, no. 9, Aug. 2021, p. 10. Pubmed, doi:10.1167/tvst.10.9.10.

Draelos, Mark, et al. “Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner.Nat Biomed Eng, vol. 5, no. 7, July 2021, pp. 726–36. Pubmed, doi:10.1038/s41551-021-00753-6.

Sastry, Ananth, et al. “Microscope-Integrated OCT-Guided Volumetric Measurements of Subretinal Blebs Created by a Suprachoroidal Approach.Transl Vis Sci Technol, vol. 10, no. 7, June 2021, p. 24. Pubmed, doi:10.1167/tvst.10.7.24.

Mangalesh, Shwetha, et al. “Macular OCT Characteristics at 36 Weeks' Postmenstrual Age in Infants Examined for Retinopathy of Prematurity.Ophthalmol Retina, vol. 5, no. 6, June 2021, pp. 580–92. Pubmed, doi:10.1016/j.oret.2020.09.004.

Mangalesh, Shwetha, et al. “Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity.Jama Ophthalmol, vol. 139, no. 5, May 2021, pp. 567–74. Pubmed, doi:10.1001/jamaophthalmol.2021.0377.