Cristian Badea, PhD

Professor in Radiology
Professor in the Department of Biomedical Engineering
Member of the Duke Cancer Institute
Address: Bryan Research Building, Room 161F
Durham, NC 27710
Phone: (919) 684-7509

Research Interests

  • Our lab's research focus lies primarily in developing novel quantitative imaging systems, reconstruction algorithms and analysis methods.  My major expertise is in preclinical CT.
  • Currently, we are particularly interested in developing novel strategies for spectral CT imaging using nanoparticle-based contrast agents for theranostics (i.e. therapy and diagnostics).
  • We are also engaged in developing new approaches for multidimensional CT image reconstruction suitable to address difficult undersampling cases in cardiac and spectral CT (dual energy and photon counting) using compressed sensing and/or deep learning.


Holbrook, Matthew D., et al. “Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning.Tomography, vol. 7, no. 3, Aug. 2021, pp. 358–72. Pubmed, doi:10.3390/tomography7030032.

Clark, D. P., and C. T. Badea. “Advances in micro-CT imaging of small animals.Phys Med, vol. 88, Aug. 2021, pp. 175–92. Pubmed, doi:10.1016/j.ejmp.2021.07.005.

Shoghi, Kooresh I., et al. “Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine.Tomography, vol. 6, no. 3, Sept. 2020, pp. 273–87. Pubmed, doi:10.18383/j.tom.2020.00023.

Holbrook, M. D., et al. “MRI-Based Deep Learning Segmentation and Radiomics of Sarcoma in Mice.Tomography, vol. 6, no. 1, Mar. 2020, pp. 23–33. Pubmed, doi:10.18383/j.tom.2019.00021.

Clark, Darin P., et al. “Spectrotemporal CT data acquisition and reconstruction at low dose.Med Phys, vol. 42, no. 11, Nov. 2015, pp. 6317–36. Pubmed, doi:10.1118/1.4931407.

Ashton, Jeffrey R., et al. “In vivo small animal micro-CT using nanoparticle contrast agents.Front Pharmacol, vol. 6, 2015, p. 256. Pubmed, doi:10.3389/fphar.2015.00256.

Clark, D. P., and C. T. Badea. “Micro-CT of rodents: state-of-the-art and future perspectives.Phys Med, vol. 30, no. 6, Sept. 2014, pp. 619–34. Pubmed, doi:10.1016/j.ejmp.2014.05.011.

Badea, C. T., and D. Panetta. “High-Resolution CT for Small-Animal Imaging Research.” Comprehensive Biomedical Physics, edited by A. Brahme, vol. 2. X-Ray and Ultrasound Imaging, Elsevier, 2014, pp. 221–42. Manual, doi:10.1016/B978-0-444-53632-7.00210-0.