H. Cecil Charles, PhD

Associate Professor of Radiology
Member of the Duke Cancer Institute
Address: 2424 Erwin Road, Suite 301, Hock Plaza
Durham, NC 27705
Phone: (919) 684-7921
Email: cecil.charles@duke.edu

Research Interests

Dr. Charles is an Associate Professor of Radiology, a chemist and an expert in MR imaging and spectroscopy with over 40 years of experience in nuclear magnetic resonance. He serves as the Scientific Director of the Duke Center for Advanced Magnetic Resonance Development.  He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as imaging biomarkers. He is also director of the Duke Image Analysis Laboratory which is active in conducting clinical trials in CNS disorders (schizophrenia, MCI, AD), cancer, osteoarthritis and lung disease using imaging based biomarkers. His lab has developed approaches for imaging lung function (ventilation and V/Q) in humans with 19F MRI.

Publications

Hora, Martin, et al. “Effect of gait and velocity on in-vivo tibial loading in humans.” American Journal of Physical Anthropology, vol. 171, WILEY, 2020, pp. 124–124.

Goralski, Jennifer L., et al. “Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.Jci Insight, vol. 5, no. 2, Jan. 2020. Pubmed, doi:10.1172/jci.insight.133400.

Mammarappallil, Joseph G., et al. “Utilization of 19F MRI for Identification of Iraq-Afghanistan War Lung Injury.Mil Med, vol. 185, no. Suppl 1, Jan. 2020, pp. 50–56. Pubmed, doi:10.1093/milmed/usz284.

Charles, H. C., et al. “Imaging Collateral Ventilation - Strategies Using 19F Perfluorinated Gas Magnetic Resonance Imaging.” American Journal of Respiratory and Critical Care Medicine, vol. 201, 2020.

Zapol, Warren M., et al. “Pulmonary Delivery of Therapeutic and Diagnostic Gases.J Aerosol Med Pulm Drug Deliv, vol. 31, no. 2, Apr. 2018, pp. 78–87. Pubmed, doi:10.1089/jamp.2017.1431.

Kraus, Virginia Byers, et al. “Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.Arthritis Rheumatol, vol. 70, no. 1, Jan. 2018, pp. 80–87. Pubmed, doi:10.1002/art.40348.

Charles, H. C., et al. “Visualization And Evaluation Of Regional Treatment Response In Subjects With Asthma Using 19f Mri Of Perfluorinated Gases Mixed With Oxygen And 1h Mri Using Oemri.” American Journal of Respiratory and Critical Care Medicine, vol. 195, AMER THORACIC SOC, 2017.

Goralski, J. L., et al. “PERFLUORINATED GAS MRI DETECTS REGIONAL VENTILATION HETEROGENEITY IN CF.” Pediatric Pulmonology, vol. 51, WILEY-BLACKWELL, 2016, pp. 275–275.