Mark Oldham, PhD

Professor of Radiation Oncology
Member of the Duke Cancer Institute
Address: 04214 Duke South Clinics, Duke South Clinics
Durham, NC 27710
Phone: (919) 668-0349

Research Interests

Dr Oldham is the Director of the Duke Medical Physics MS/PhD Graduate Program.

He is Professor in the Department of Radiation Oncology, and Director of the Optical Biophysics and 3D Dosimetry Lab. The lab has received NIH R01 funding to develop optical imaging techniques for 3D dosimetry.  He has patented and published on several novel radiation treatment techniques (including XPACT and RECA - Radiotherapy Enhanced by Cherenkov photo-Activation) with exiting potential to invoke systemic anti-cancer immunogenic response.  A phase I clinical trial of XPACT is underway.  The lab has pioneered novel pre-clinical treatment capabilities including mini-beam grids, and ultra-high-resolution IMRT.  The lab has also developed novel optical imaging techniques for high-resolution 3D imaging of vascular networks and fluorescent gene expression in un-sectioned tissue samples.


Yoon, Suk W., et al. “A method for generating intensity-modulated radiation therapy fields for small animal irradiators utilizing 3D-printed compensator molds.Med Phys, vol. 47, no. 9, Sept. 2020, pp. 4363–71. Pubmed, doi:10.1002/mp.14175.

Adamson, Justus, et al. “Delivered Dose Distribution Visualized Directly With Onboard kV-CBCT: Proof of Principle.Int J Radiat Oncol Biol Phys, vol. 103, no. 5, Apr. 2019, pp. 1271–79. Pubmed, doi:10.1016/j.ijrobp.2018.12.023.

Moran, Jean M., et al. “Executive summary of AAPM Report Task Group 113: Guidance for the physics aspects of clinical trials.J Appl Clin Med Phys, vol. 19, no. 5, Sept. 2018, pp. 335–46. Pubmed, doi:10.1002/acm2.12384.

Mein, Stewart, et al. “Development of a 3D remote dosimetry protocol compatible with MRgIMRT.Med Phys, vol. 44, no. 11, Nov. 2017, pp. 6018–28. Pubmed, doi:10.1002/mp.12565.

Oldham, M., et al. “Initial experience with optical-CT scanning of RadBall Dosimeters.J Phys Conf Ser, vol. 250, no. 1, Dec. 2010. Pubmed, doi:10.1088/1742-6596/250/1/012079.

Wang, Z., et al. “Dose Verification of Stereotactic Radiosurgery Treatment for Trigeminal Neuralgia with Presage 3D Dosimetry System.J Phys Conf Ser, vol. 250, no. 1, Dec. 2010. Pubmed, doi:10.1088/1742-6596/250/1/012058.

Grant, R. L., et al. “Three-Dimensional Dosimetry of a Beta-Emitting Radionuclide Using PRESAGE Dosimeters.J Phys Conf Ser, vol. 250, no. 1, Dec. 2010. Pubmed, doi:10.1088/1742-6596/250/1/012095.

Thomas, Andrew, et al. “A comprehensive method for optical-emission computed tomography.Phys Med Biol, vol. 55, no. 14, July 2010, pp. 3947–57. Pubmed, doi:10.1088/0031-9155/55/14/001.